Non-infectious inflammatory diseases of the lung Flashcards

1
Q

sarcoidosis

A

multisystem granulomatous inflammatory disease of unknown etiology

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2
Q

what are the risk factors for sarcoidosis (ethnicities, exposures)?

A

african americans
danes
swedes
exposure to insecticides, ag employment, microbial aerosols

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3
Q

what are the general manifestations / clinical presentation of sarcoidosis?

A

involvement of lymphatic and pulmonary system

dry cough, SOB

like TB without the infectious part

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4
Q

what is seen on PE with sarcoidosis?

A
adenopathy 
skin lesions (lupus pernio, erythema nodosum)
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5
Q

what is seen on labs in sarcoidosis?

A

calcium levels
liver enzymes
creatinine

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6
Q

what ancillary tests should be performed for sarcoidosis?

A

ECG (for heart block)
opthalmologic
TB

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7
Q

what is seen on PFTs in sarcoidosis?

A

restrictive

decreased TLC
decreased VC
decreased RV
decreased DLCO

usually interstitial - limits expansion

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8
Q

what is the diagnostic procedure for sarcoidosis? what does it check for?

A

bronchoscopy to check for

BAL - lymphocyte, granulocyte count
CD4/CD8

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9
Q

when are systemic corticosteroids indicated for sarcoidosis?

A
cardiac involvement 
ocular disease 
neuro disease 
hypercalcemia 
lupus pernio 
symptomatic stage II 
stage III
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10
Q

what are the CT diseases that affect the lung?

A
RA 
scleroderma 
SLE 
sjogren 
dermatomyositic and polymyositis
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11
Q

what are the demographics and clinical features of RA that affects the lung?

A

male > female 50-60 yo

ILD 50%

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12
Q

what is the presentation for rheumatoid lung disease?

A

non productive cough
dyspnea on exertion
may precede joint disease by years
clubbing

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13
Q

what are the auscultatory findings of rheumatoid lung disease?

A

inspiratory fine crackles

pleural rub

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14
Q

what are the radiographic findings of rheumatoid lung disease?

A

nodules that can cavitate

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15
Q

what are the medications for rheumatoid lung disease?

A

methotrexate
etanercept
infliximab

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16
Q

what lab result is indicative of rheumatoid lung disease? why?

A

low glucose

bacteria are consuming the glucose

17
Q

what are the two types of diffuse scleroderma lung disease?

A

interstitial lung disease

limited (CREST)

18
Q

what is indicative of interstitial lung disease form of scleroderma on auscultation? what type of lung physiology is represented?

A

inspiratory crackles

restrictive lung physiology

19
Q

what is seen in the limited (CREST) form of scleroderma?

A

pulmonary HTN

decreased DLCO

20
Q

what is the most common presentation of SLE pulmonary involvement? what are other findings?

A

serositis

alveolar hemorrhage
diaphragmatic dysfunction
increased risk for DVT/PE** (hypercoagulable state)

21
Q

what constitutes sjogren syndrome lung involvement?

A

airway compromise

bronchiestasis and bronchiolitis

22
Q

what is a common manifestation of polymyositis / dermatomyositis pulmonary involvement?

A

aspiration pneumonia secondary to pharyngeal muscle weakness

23
Q

what are the PFT findings for polymyositis / dermatomyositis?

A

restrictive

24
Q

wegener’s granulomatosis

what structures are involved?

A

necrotizing granulomatous vasculitis of small and medium vessels

upper and lower respiratory tract and kidneys

25
what are the symptoms / presentations of wegener's granulomatosis?
sinus symptoms cough hemoptosis constitutional symptoms
26
which antibody is specific to wegener's syndrome?
cANCA
27
what is the diagnosis for goodpasture's syndrome?
presence of anti-glomerular base membrane antibodies
28
what is seen on bronchoscopy for goodpasture's syndrome?
persistent bloody fluid that does not clear on serial samples
29
how can diffuse alveolar hemorrhage present?
as the initial manifestation of a pulmonary vasculitis
30
what is the triad of churg-strauss syndrome?
asthma hypereosinophilia necrotizing vasculitis
31
what are the two phases of churg-strauss syndrome?
prodrome | eosinophilic
32
what is are the organ involvements in churg-strauss syndrome?
reversible airflow limitation CV complications GI - can be severe
33
what is seen on lab findings for churg-strauss syndrome?
eosinophilia (diagnostic) elevated IgE positive pANCA