Non Barb IV Induction Flashcards
Propofol: solubility
Not water soluble, lipid soluble
Propofol: prolonged gtt can lead to what. Issues w what allergy
Inc plasma TG. Egg yolk allergies.
Two forms of propofol and caution w each
Diprivan EDTA (bronchoconstriction in asmthatics). Na metabisulfite- sulfa allergy= bronchospasm
Propofol MOA. No what
Gaba A- major. Glycine- minor. Dec dissoc of gaba from receptor. No spinal cord depression
Propofol: VD, what affects it
Large, about 4 L/KG. Exceeds hepatic BF. Wt, disease, age, other drugs
Propofol t 1/2
0.5-1.5 hrs
Barb cns fx: Dec what
CBF, ICP, CMRO2, CPP. Cerebral protection. Dec IOP
Propofol CNS: eeg effects. Onset. Age effects what
EEG burst suppression. Onset fast. ED 95- highest in little ones, dec w age
Propofol: other CNS effects
Hiccoughs, muscle twitch, hallucinate, opisthotonos. Vit e resemblance= cerebral protection
Propofol resp fx
Apnea at induction. Dec TV, RR, resp to co2/02 alt, paco2 inc ph dec. Bronchodilation in COPD. HPV remains
Propofol cv fx
25-40% dec BP (more than stp), myoc dep and vasodilation- dec SV/SVR/co. Hr same.
Propofol: doesnt potentiate what. Incidence of what is higher than tpl but less than etomidate and brevital
Muscle relaxants. Myoclonus
Propofol: antiemetic and antipruritic when. Amnestic dose. Crosses what
Sub-hypnotic doses 10 mg. >30 mcg/kg/min. Placenta (still safe)
Propofol
Induction dose
Toddler induction
1-2.5 mg/kg
As high as 3 mg in toddlers
Propofol
Ga maintenance dose
Sedation infusion
100-300 mcg/kg/min
25-100 mcg/kg/min
Propofol
Metabolism
Conjugated by liver to water soluble. Cp450. Liver func doesnt alter rate.
Propofol metab
Metabolites
Excretion
Mostly inactive except for 4 hydroxypropofol, 1/3 as potent. Renal exc, CRF doesnt affect clearance
Etomidate
Derivative of what
Solvent
PH in bottle/body
Carboxylated imidazole. Propylene glycol. Bottle- 6.9 (water soluble), lipid soluble at physio pH 8.2
Etomidate
MOA
Selective gaba A receptor, increases affinity of gaba
Etomidate
Onset, Vd
Rapid. ~3.5 l/Kg. Redistribution terminates effect, 3 compartment model
Etomidate
E 1/2t, binding, what impacts metab
4 hrs. Highly protein bound. Hepatic extraction ratio, liver BF changes prolong it.
Etomidate CNS
Direct brain effects
Rapid LOC. No analgesia. Decreased CBF, ICP, CMRO2, IOP.
Etomidate CNS
EEG/seizure effects
Increases EEG activity if epilepsy, rare grand mal sz. May have myoclonus. Anticonvulsant prop.
Etomidate resp fx
Overall
Min dep of co2 response. Dec in TV, inc in RR. Hiccups and coughing.
Etomidate CV
What sets it apart
Minimal change d/t lack of SNS/baroreceptor effect. HR/ABP/PAP/CO/SVR/PVR unchanged.
Etomidate endocrine
Dose dep inhib of enzymes in biosynthesis of cortisol/Aldosterone. Major: 11 beta hydroxylase. Suppression for 6 hrs.
Etomidate doses
Induction
0.3 mg/kg
Etomidate maintenance dose, with what
Gtt 10 mcg/kg/min with n20 and opioid
Etomidate sedation dose
5-8 mcg/kg/min for short procedure
Etomidate dose
Rectal, in who
6.5 mg/kg in peds
Etomidate
3 misc effects
High NV incidence, myclonus, enhances NMDR activity
Etomidate metabolism
Liver ester hydrolysis OR n dealkylation to carboxylic acid. Faster than TPL. Mostly renal, some biliary excretion
Ketamine
Derivative, solubility, solution
Phencyclidine. Lipid sol. Acidic solution.
Ketamine
Mixture of what, enantiomer difference
Racemic of R and S. S- analgesic, faster metab, less emergence delirium
Ketamine MOA
Receptors it interacts with 5 main
NMDA (ion glutamate), opioid (mu/kappa/delta), monoaminergic (pain man), muscarinic antag, ca ch
NMDA receptor activation through ketamine
Na and Ca in, k out, action potential. Ca- role in memory inhibition. Ligand and voltage dependent.
Ketamine metabolism
How it happens
1st pass, liver enzymes, n demethylation then hydrozylation (norketamine to hydrozynorketamine). Conjugation to water soluble. Urine excretion
Ketamine
Metabolism impacted by what
Total clearance equal to liver BF
Ketamine
Distribution, onset, duration
2 compartment. Highly lipid soluble, large vd (3l/kg). Rapid onset, short duration.
Ketamine
E 1/2t
2-3 hrs
Ketamine CNS
Depresses what, stim what
Depresses neuronal function in advanced areas of cortex/thalamus. Stim hippocampus
Ketamine CNS
What not as prominent as benzos.
Onset, peak, termination
Amnesia. 30 sec, 1 min, 15 min.
Ketamine CNS
Direct effects
Increased CBF, CMRO2, ICP, and IOP
Ketamine CNS
Other effects
Nystagmus, pupil dilation, tears, secretions, myoclonus, inc muscle tone, emergence reactions
ketamine- spinal analgesia
Dose. Receptor activity. Antagonism.
0.2-0.5 mg/kg IV. Mu receptor (s enantiomer). NMDA antag (dorsal horn)
Ketamine respiratory
Minimal. No alt co2 resp. Bronchial relaxation. Inc PVR and salivation
Ketamine CV
Direct effects, how
Indirect effect
Inc BP, HR, CO. From sympathomimetic (central) effect in nucleus solitarus. Myo depressant, inhib NE reuptake.
Ketamine
Premedication dose
What you use it for
Sedative/analgesic
0.2-0.5 mg/kg
Ketamine induction dose
IV, IM
1-2 mg/kg
4-8 mg/kg IM
Ketamine maintenance dose
1-2 mg/kg/hr
Ketamine
PO and nasal dose
6 mg/kg
Contraindications for ketamine 6
Inc ICP, open eye injury, CAD (sole anes), vascular aneurysm, systemic/pulm htn, psych diseases
Dexmedetomidine
Solubility. Agonist where. Produces what
Water. Selective A2. Mimics sleep, hypnosis @ locus ceruleus, analgesia @ SC
Dexmedetomidine
CNS effects
Dec CBF, no sig ICP or CMRO2 change. Dec MAC and dec opioid requirement. Depresses thermoreg
Dexmedetomidine CV
Effects
Dec HR, SVR, BP. Bolus can temp inc bp then drop suddenly. Potential for heart block and asystole. Atten CV resp to pain/catecholamine levels
Dexmedetomidine Resp
Effects
Minimal RR chance. Small dec TV. No co2 change. Upper a/w obstruc maybe
Dexmedetomidine
Metabolism
Rapid. Conjugation, n methylation, hydroxylation. Metabolites cleared in urine and bile.
Dexmedetomidine
Binding. E 1/2. How it effects other drugs
Protein. 2-3 hrs. Inhib cyp 450 (esp effects opioid clearance)
Dexmedetomidine
How its most commonly used, dose
Adjunct to GA. 1 mcg/kg bolus over 10 min then 0.2-1 mcg/kg/hr gtt
Dexmedetomidine antagonist, use
Antipamezole. Mainly used to reverse CV fx.