Non alcoholic fatty liver disease Flashcards

1
Q

Describe the spectrum of disease from least to most severe

A

Steatosis, steatohepatitis, fibrosis and cirrhosis

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2
Q

What is a brief description of NAFLD

A

Fat deposits in the liver, not caused by alcohol or a viral infection, that causes liver disease

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3
Q

What syndrome does NAFLD usually derive from

A

Metabolic syndrome

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4
Q

What is the criteria for metabolic syndrome

A

3/5 of the following. Obesity, hypertension, diabetes, hypertriglyceridaemia and hyperlipidaemia

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5
Q

NAFLD occurs in 3/5 obese people. True or false

A

False it is 3/4 of obese people

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6
Q

Describe steatosis

A

Decreased secretion of fatty acids into the blood and increased uptake and synthesis of fatty acids from the blood

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7
Q

What is happens to the nucleus of cells in steatosis

A

Nucleus is pushed to the side of the cell

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8
Q

What is thought to be linked to steatosis

A

Insulin resistance

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9
Q

What is the appearance of the liver in steatosis

A

Large, soft, yellow and greasy

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10
Q

Steatosis and inflammation=what???

A

Steatohepatitis

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11
Q

How does steatohepatitis cause fibrosis

A

Causes stellate cells to lay down fibrotic tissue and this causes fibrosis

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12
Q

Symptoms

A

Once significant damage occurs (fibrosis/cirrhosis); hepatomegaly, pain, jaundice and accumulation of ascites

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13
Q

What is effect of the LFTs in NAFLD compared to AFLD

A

Increase in ALTs and smaller increase in ASTs. In AFLD ASTs have a large increase and the AST:ALT ratio is over 2.

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14
Q

How to diagnose

A

US/CT/MRI. Biopsy of liver that shows over 5% of fat is abnormal

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15
Q

Treatment

A

Fibrosis and cirrhosis are irreversible but normal cirrhosis treatment. Adopt a healthy lifestyle and possibly medication for blood glucose levels to prevent worsening of insulin resistance

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