Alcoholic-related liver disease Flashcards
What organ absorbs majority alcohol and passes it to liver
Stomach
What is the product of alcohol metabolism
Acetaldehyde
What are the three metabolic pathways for alcohol
CYP2E1, ADH and catalase
What does an increase in NADH cause in terms of fatty acids
An increase in fatty acid synthesis
What does a decrease in NAD+ do in terms of fatty acids
Decreases fatty acid oxidation
What immune cell destroys hepatocytes when an aldehyde adduct is formed
Neutrophils
What is an aldehyde adduct
A product when acetaldehyde binds to an own body molecule
Symptoms
Hepatomegaly, pain, jaundice, ascites (cirrhosis symptoms
What are mallory bodies
Damaged intermediate filaments in the cytoplasm due to alcoholic hepatits
Normal blood test changes
Increased neutrophils, decreased platelets and decreased blood sugar
LFTs
Super increased AST, inc. ALT, ALP and GGT
Diagnosis
US and blood test
Treatment
No alcohol, corticosteroids and cirrhosis treatment if necessary
