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Mouse > Nomenclature > Flashcards

Nomenclature Flashcards

1
Q

How to indicate substrains?

A

/

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2
Q

Describe the appearance of a lab code and it’s location.

A

1-5 letters, starting with an uppercase and followed by lowercase. Follows ‘/’. May present in cumulative strings

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3
Q

How to list a F1 hybrid

A

Female ‘x’ Male

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4
Q

How to list a RI strain from two inbred parental strains

A

Female’X’Male - Specific line

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5
Q

How to list a mutant gene

A

Parent gene (italics, starting with uppercase letter), mutant allele in superscript

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6
Q

How would a co-isogenic gene look?

A

Strain/Labcode-Gene(italics), allele(superscript)

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7
Q

How to list a transgene

A

Strain - Tg(brief description)#(assigned)Labcode
Example: FVB-Tg(MMTV-Erb2)1Led
No part is ever italicized - Not part of native genome

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8
Q

How to list transgene that causes insertional mutation in identified endogenous gene?

A

Gene (italics), tg1Labcode (superscript)

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9
Q

How to list targeted mutation.

A

Recipient;donor-Gene (italics), tm#Labcode (superscript)

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10
Q

How to list gene replacement or knock in

A

Gene replaced, gene added (superscript)

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11
Q

At which generation is backcrossing complete for a congenic line? How is this noted?

A

N10, noted with a ‘.’ between background and donor strain

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12
Q

What occurs after N5 backcrossing?

A

Incipient congenic, ‘;’ between background an donor strain

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13
Q

How is the background strain indicated if of mixed genetic origin?

A

STOCK

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14
Q

How is the donor strain indicated if of mixed origin?

A

Cg

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15
Q

How are outbred stock that meet specific criteria designated?

A

Labcode:Stock

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16
Q

How are animal and human genes indicated?

A

All alleles. Human genes all capitalized, animal genes only have the first letter capitalized.

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17
Q

How are alleles written?

A

Italics. Capitalized in dominant inheritance, lowercase if recessive inheritance.

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18
Q

How are proteins indicated?

A

No italics, all capitalized.

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19
Q

How is a stock indicated?

A

Lab Code: Stock (Origin of stock)

20
Q

How many brother x sister matings constitute a strain? Why?

A

20 brother-sister or parent-offspring. After this point uniform genome with only 0.01% residual heterozygosity.

21
Q

How is a strain indicated?

A

Unique, brief symbol with uppercase letters and numbers. Related inbred strain names should indicate relatedness.

22
Q

How are substrains indicated?

A

Strain/Substrain

23
Q

Describe a Laboratory Registration Code? Who creates these?

A

1-5 letters. Assigned by Institute of Lab Animal Research (ILAR), now Board of Animal Health Science, Conservation, and Research (BAHSCR)

24
Q

If a lab creates multiple substrains, how are those indicated?

A

Strain/SerialNumberSubstrain
FL/1Re, FL/2Re

25
Q

What are exceptions to naming of substrains?

A

BALB/c - Not a substrain
DBA/1 and DBA/2 - Separate strains, not substrains

26
Q

How are substrains of substrains developed? How are they indicated?

A

Arise when colony is maintained by a new investigator, or a new colony is established. Strain/SubstrainSubsubstrain

27
Q

How are F1 hybrids indicated? F2?

A

(Maternal x Paternal) F#/LabCode.
Shortened to MPF#/LabCode (B6D2F1/J). F2 hybrids and beyond are indicated in the same way.

28
Q

How are recombinant inbred strains indicated?

A

Think railroad crossing!
Maternal X Paternal Serial#
No punctuation, unless paternal strain ends in number. If so, hyphen then serial #

29
Q

When is the generational term ‘N’ used?

A

Backcrossing. F is for inbreeding.

30
Q

How are congenic mice indicated?

A

Recipient.Donor-Gene^allele/Lab code

31
Q

What is an incipient congenic? How is this indicated?

A

Not backcrossed for 10 full generations. Indicated by ;

32
Q
A
33
Q

How are coisogenic mice indicated?

A

Strain/Substrain - Gene^Allele

34
Q

How is an endonuclease mediated transgenic mouse indicated?

A

Strain-Gene^em#LabCode

35
Q

How is a consomic strain described?

A

Host strain-Chromsome^Donor

36
Q

How is the rearing or microbiological status of stocks indicated?

A

Lab code:StockRearing or microstatus

37
Q

How is the origin or remove ancestry of a stock indicated?

A

Lab code: Stock (Stock2)

38
Q

How are mutant stocks indicated? What if they are heterozygous for the gene of interest?

A

Lab Code: Stock - Gene
If het: Lab code: Stock - +Gene

39
Q

What is a recombinant congenic strain? How is it indicated?

A

Crossing two inbred strains followed by a few backcrosses.
Recipient c donor

40
Q

What are advanced intercross lines. How are they indicated?

A

Producing F2 of two inbred strains and then avoiding sibling mating to increase possibility of tightly linked genes recombining.
Lab code: Inbred strain 1, inbred strain 2 G
G is generation number, starts after F2 generation.

41
Q

What is a conplastic strain? How is it indicated?

A

Cytoplasmic genome (mitochondria) is put on a different strain that maintains its nuclear genome.
Nuclear genome strain -mt^Cytoplasmic gene donor

42
Q

How are segregating inbred mutant strains indicated?

A

Strain/Substrain - Gene^Allele / +

42
Q

Describe genes carried in repulsion. How is this indicated?

A

Carried on different chromosome. Strain/Substrain - Gene1 +/+ Gene2^Allele

43
Q

Describe genes carried in coupling. How is this indicated?

A

Carried on same chromosome.
Strain/Substrain - Gene1 Gene2^Allele /++

44
Q

How are recombinant congenic strains that have been backcrossed once or twice described differently than those that have been backcrossed more?

A

AcB vs AcB(N#)

Mouse (17 decks)

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