Nitrofurantoin Flashcards
1
Q
Nitrofurantoin
A
Damaged bacterial DNA
Only active against urinary pathogens (e.coli)
Narrow spectrum
Bactericidal
2
Q
Side effects
A
Nausea
GI disturances
Risk of peripheral neuropathy in renal impairment
3
Q
Patient counselling
A
Take with or after food
May colour urine yellow or brown (harmless)
4
Q
Pregnancy
A
Avoid at term
5
Q
Contraindications
A
Infants less than 3 months
Renal impairment - increases toxicity and decreases amount of drug that enters urine, making it less effective.
6
Q
Important interactions - peripheral neuropathy
A
Amiodarone
Isoniazid
Metronidazole
Phenytoin
7
Q
MHRA
A
Pulmonary + hepatic ADR
