Clindamycin

Question 1

Clindamycin

Answer 1

Narrow spectrum
Bacteriostatic (inhibits growth and reproduction but doesn’t directly kill them).
Binds to cell walls, inhibiting cell wall protein synthesis

Question 2

Works against what types of bacteria?

Answer 2

Gram + aerobes
Anaerobes

Question 3

Indications

Answer 3

Staphylococcal joint + bone infections
Intra-abdominal sepsis
Cellulitis
Skin and soft tissue infections

Question 4

Side effects

Answer 4

GI disturbances
- Antibiotic associated colitis (c.diff)
- Can be fatal
- Most commonly associated with clindamycin
Oesophageal disorders
Taste disturbances
Jaundice
Blood disorders
Rash
SJS

Question 5

Who is most likely to get C.diff from Abx?

Answer 5

Middle-aged, elderly women.
ESPECIALLY after opertation.

Question 6

Clindamycin - pt. counselling

Answer 6

If diarrhoea develops, STOP and see GP

Question 7

Monitoring

Answer 7

Hepatic + renal function in infants AND all patients where treatment exceeds 10 days.

Question 8

Contraindications + cautions

Answer 8

Do not use in patients with existing diarrhoea