Cephalosporins Flashcards
1
Q
MoA
A
Interferes with bacterial cell wall synthesis
Similar spectrum of activity to penicillin’s
Broad spectrum
Bactericidal
2
Q
Use
A
UTI (pregnancy or second line)
Sinusitis
Otitis media
3
Q
1st generation - CEFA
A
Cefalexin
Cefradine
4
Q
2nd generation
A
Cefuroxime
Cefaclor (protractd skin reactions, especially in children)
5
Q
3rd generation (parenteral)
A
Cefixime (orally active)
Ceftriaxone (OD, meningitis)
Cefotaxime (meningitis)
6
Q
5th generation (parenteral)
A
Ceftaroline
- CAP
- Complicated skin and soft tissue reactions
7
Q
SE
A
Hypersensitivity
- Do not give in history of immediate penicillin hypersensitivity
- If no alternative and essential, give 3rd gen or cefuroxime
Abx associated colitis
- More common in 2nd and 3rd gen cephalosporins
