Niesseria bact Flashcards
regarding GONOCOCCI
the most important viurlence factor is
and it’s function
Pilli
mediate attachment to mucosal cells and antiphagocytic.
Non-piliated strains are avirulent.
IgA1 protease function \;
hydrolyzes secretory IgA1 and allows
attachment of the organism to the mucosa
Lipooligosaccharides located in… and it’s function is
cell wall
and are responsible for the endotoxic effects occurring in gonococcal infections.
Opa proteins are present in …and plays role in..
outer membrane protein.
and attachment of
gonococci to host cells.
in gonococci
Por function
prevent phagosome-lysosome fusion
where does the gonnococci attack
mucous membranes of the genitourinary tract,
regarding Female gonorrhoea:
will cause
cervicitis and urethritis with mucopurulent discharge.
regarding Female gonorrhoea:
the gonorrhoea will extend in utrine tubes and cause
salpingitis and pelvic inflammatory disease (PID); leading
to fibrosis of the tubes,
fibrosis of the tubes, will cause
ectopic pregnancy and infertility in 20% of cases.
Male gonorrhoea will cause
acute anterior urethritis with purulent urethral discharge
and dysuria.
if the male gonorrhoea became chornic will cause
scanty discharge (morning drop).
complicated by urethral stricture, prostatitis and epididymitis.
in young girl gonorrhoea will cause
Vulvo-vaginitis
their vigana columnar epithelum
In both sexes, blood invasion may occur, though rarely, leading to
disseminated gonococcal infections (DGI)manifesting as
septic arthritis, tenosynovitis, skin
pustules and rarely endocarditis.
Repeated gonococcal infections are common due to:
-Antigenic variation in the pili and outer membrane proteins.
-Superficial nature of infection so IgG has little protective action.
-Secretory IgA1 is destroyed by IgA1 protease
why Direct smears stained by gram are usually difficult
presence of organism in small number and mixed with normal flora.
why blood cultures may need in dignosis
DGI. and Other sexually transmitted diseases
eg:
syphilis, non-gonoccocal urethritis caused by
Chlamydia trachomatis and HIV can coexist with gonorrhoea
the treatment of gonohrrea is
intramuscular dose of ceftriaxone
recommended for partners
The prevention of gonorrhoea involves
the use of condoms
Neonatal ophthalmia is prevented by:
erythromycin or
tetracycline eye drops or eye ointment immediately after birth.
the orgnaism that produce menigitits epidemic is
meningococci
the most iportant virulence factor in meningococci ?
Capsular polysaccharide antigens.
divide the bacateria into 13 serogroups
the most important serogroups of meningococci capsule
A.B.C.Y.W
what serogroups that cuase epidemics ?
Group A and B
Properties of the polvsaccharide capsule are:
enhances virulence by its antiphagocytic action.
antigen that defines the serologic groups.
-protective antibodies.
the most severe form of meiningococcaemia
Waterhouse-Friderichsen syndrome,
why in (meningococcaemia) the CSF is under tension
due to large number of pus cells;
