Nicotinic Acid: Niacin

Question 1

Niacin
MOA

Answer 1

Effects lipolysis in adipocyte tissue. Decreases plasma triglyceride synthesis and reduces the release of VLDL from the liver. Results in reduced circulating VLDL, TG and LDL. Increases HDL by limiting Apo-A1 breakdown.

Question 2

Niacin
Abs/Distrb/Elim

Answer 2

Given orally; excreted in the urine

Question 3

Niacin
Clinical use

Answer 3

Dyslipidaemia (when statin can’t be used)

Question 4

Niacin
Adverse effects

Answer 4

Flushing (pretreatment of aspirin can prevent this), palpitations, GIT disturbance
High dose can impair liver function, glucose tolerance, precipitate gout