Bile acid sequestrants: Colestyramine

Question 1

Colestyramine
MOA

Answer 1

Binds bile acids in intestine and prevents reabsorption and enterohepatic recirculation of cholesterol. Stimulates the synthesis of LDL receptors which results in increased uptake of LDL into liver cells (20% reduction in LDL)

Question 2

Colestyramine
Abs/Distrb/Elim

Answer 2

It is given orally and is not absorbed so there are no adverse systemic effects.

Question 3

Colestyramine
Clinical use

Answer 3

Hypercholesterolaemia

Question 4

Colestyramine
Adverse effects

Answer 4

GI distress bloating, constipation, etc
Unwanted increase in TG through inc HMG-CoA reductase cholesterol synthesis and VLDL.