Newborn Stem Cells Flashcards
What the the two most banked and rich sources of newborn stem cells?
Umbilical cord blood and cord tissue
What is cord blood
Blood left over in the umbilical cord and placenta after the cord has been clamped and cut
Who is cord blood and cord tissue identical to?
The newborn
What type of cells are rich in cord blood?
Hematopoietic stem cells
What does it mean to be multipoteTnt?
Cells that can differentiate into a subset of cell types
Cord Tissue originates from what?
The actual umbilical cord itself
Cord tissue is rich in what type of cells?
Mesenchymal stem cells
Steps of a stem cell transplant
Diagnosis
Ablation
Infusion
Engraftment
Recovery
Conditions treated with HSCT
Blood disorders
Cancers
Immune Disorders
Metabolic Disorders
What type of matching do we do to conduct HSCT?
HLA Matching (Human Leukocyte Antigen)
What is important about the HLA complex?
It’s a key component in the immune response
What is the HLA complex?
A region of ~200 genes located on chromosome 6 that code for proteins found on the surface of cells throughout the body
What are a couple downfalls about HLA?
This region is the most polymorphic region in the human genome, and it is inherited as a haplotype.
Why are stem cell transplants risky?
Failure to engraft
Graft vs host disease
Infections
Relapse of the disease
Death
What can reduce risk of HLA Matching?
Risks can be reduced wit higher doses of stem cells and a closely matched donor
