Craniofacial Disorders

Question 1

What sex is more commonly having cleft lip/palate?

Answer 1

Males

Question 2

Percent prevalence for cleft lip, palate, & lip and palate?

Answer 2

21% lip
46% lip and pallate
33% palate

Question 3

Order of lip development

Answer 3

Frontonasal
L. Maxillary
L. Mandibular.
R. Mandibular
R. Maxillary

Question 4

Which week the palate begin and end development?

Answer 4

Week 6 begins and completed by week 12

Question 5

Syndromic vs non-syndromic etiology stats

Answer 5

Syndrome 30%
Non-syndromic 70%

Question 6

What types of gene functions can lead to cleft lip and palate?

Answer 6

Growth factors, signaling factors, transcription factors

Question 7

Environmental factors that lead to clefting

Answer 7

Alcohol, tobacco, anti-epileptic drugs, (Dilantin, valproic acid), thalidomide, dioxide, retinoic acid

Question 8

Recurrence risk increases with:

Answer 8

Severity of trait, number of affected relatives, sex of person, how closely related

Question 9

Recurrence risk for fhx

Answer 9

Monozygotic twin 60%
Dizygous twin 10%
Sibling and child 3-5%
Niece/nephew 1%, 1st cousin <.5%

Question 10

What alone is more commonly associated with a syndrome?

Answer 10

Cleft palate alone