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LE Micro exam 2; 2015 > New > Flashcards

New Flashcards

0
Q

Antivirals that prevent genome replication (5)

A
  1. Acyclovir
  2. Ganiclovir
  3. Valganciclovir
  4. Foscarnet
  5. Ribavirin
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1
Q

Antivirals that prevent entry (3)

A

Enfuritide
Amantidine
Rimantadine

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2
Q

Ganciclovir

A

Treat CMV

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3
Q

Enfuritide

A

Prevents HIV

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4
Q

Foscarnet

A

Treat herpes
IV
Toxic- last resort

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5
Q

Valganciclovir

A

Treat EBV

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6
Q

Ribavirin

A

Nucleoside inhibitor for RNA virus

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7
Q

Amantidine and Rimantadine

A

Prevent Influenza by blocking M2 channel

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9
Q

3 important immune cell types in vaccinations

A

CD4+ T cell, CD8+ T cell, B cell

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10
Q

Acyclovir

A

Treat herpes
Nucleoside inhibitor
1st antiviral approved for use

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11
Q

Antiviral that prevents viral protease

A

Ritonavir- HIV

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12
Q

Alphaherpesvirus HSV1 HSV2 genome and virion

A

dsDNA, enveloped

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13
Q

Betaherpesvirus genome and virion

A

dsDNA, enveloped

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14
Q

Antiviral challenges

A

Bioavailability
Toxicity
Specificity

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15
Q

Prototypical member of betaherpesvirus group

A

CMV– EBV; burkett’s lymphoma- most common childhood cancer in africa

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16
Q

Most common childhood cancer in africa

A

Burkett’s lymphoma

17
Q

Gammaherpes virus genome and virion

A

dsDNA, enveloped

18
Q

Prototypical member of gamma herpes virus

A

EBV

19
Q

Latency where in alphaherpesvirus

A

Sensory peripheral ganglia

20
Q

Latency where in gammaherpesvirus

A

Lymphoid tissue- in memory B cells

21
Q

Influenza genome and virion

A

-ssRNA, enveloped, replicate in NUCLEUS

22
Q

Gammaherpes virus targets

A

B and T lymphocytes

23
Q

Major surface proteins for influenza

A

HA, NA

24
Q

Adenovirus genome and virion

A

dsDNA, Nonenveloped

25
Q

What virus is used for gene therapy

A

Adenovirus

26
Q

Rhinovirus genome and virion

A

+ssRNA, nonenveloped - will cause upper respiratory infection- red nose

27
Q

What initiates reverse transcriptase

A

nucleocapsid in the cytoplasm

28
Q

What is necessary for reverse transcription to occur?

A

Need higher levels of NTP

29
Q

What’s necessary for integration of retrovirus to occur?

A

Must access the nucleus

30
Q

Retrovirus accesses nucleus during ___

A

Mitosis

31
Q

Human T cell leukemia virus genome and virion

A

+ssRNA and enveloped

32
Q

2 diseases of HTLV

A
  1. Adult t cell lymphoma- tumors- treat chemo- 30-50 years incubation
  2. HAM/TSP- bladder, back pain, weak legs- 3 year incubate
33
Q

Leading cause of preventable blindness

A

Chlamydia

34
Q

HPV genome and virion

A

dsDNA, NON ENVELOPED

35
Q

HIV genome and virion

A

+ssRNA enveloped. targets CD4 cells

LE Micro exam 2; 2015 (5 decks)

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