Neutering and Reproductive Disease in Small Mammals Flashcards

1
Q

Why would you perform an ovariohysterectomy in small mammals?

A
  • Prevent unwanted litters e.g. siblings, pelvic closure in guinea pigs.
  • Protect against common diseases of reproductive tract
  • Allow for rabbit pairing (male and female) and for groups of animals to live together e.g. singular male guinea pig with many females.
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2
Q

Why would you perform castration in small mammals?

A
  • Prevents unwanted litters
  • Prevent spraying
  • Can help with aggression?
  • Allow for rabbit pairing (male and female) and for groups of animals to live together e.g. singular male guinea pig with many females.
  • Protect against common diseases of reproductive tract?
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3
Q

Why would you not want to perform an ovariohysterectomy or castration in small mammals?

A
  • Risk of general anaesthetic?
  • Ferrets -> related to disease!
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4
Q

How do you perform an ovariohysterectomy in rabbits and guinea pigs?

A
  • Abdominal approach between the umbilicus and pubic symphysis (Incision 2cm long, midway between umbilicus and pubic symphysis.)
  • Careful tissue handling, especially with the gut – adhesions easily formed.
  • Haemostatic clips or suture to ligate.
  • Always use intradermal sutures to close skin – they nibble and their friends nibble!
  • Monofilament suture for ligatures, muscle, sub cut and skin. Avoid skin glue if possible.
  • The surgery itself is the same method as cats and dogs.
  • Rabbits have two cervix but this doesn’t change what you do.
  • They can be hard to locate the uterus if they are young. Tip is to look for the fat attached to the reproductive tract – more dense than other body fat.
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5
Q

What methods are available for castrating small mammals? Which one should you use for each species?

A
  • Scrotal (open or closed)
  • Pre-scrotal (open or closed)
  • Abdominal
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6
Q

How do you perform scrotal castration in small mammals? Why is it not a preferred method?

A
  • Similar to a cat, except that the inguinal canals must be closed if an open technique is used. ​
  • 1 to 1.5cm incision made through the skin and vaginal tunic ventrally on both sides of the scrotum, parallel to penis.​
  • Testis is removed from the tunic and ligatures placed. ​
  • The large testicular fat pad is removed as well with the testes.
  • Skin glue to close, sutures difficult in scrotal tissue. ​

Disadvantages - It increases the chances of some post op complications:​
* Wound breakdown​
* Infection/Abscessation
* Scrotal haematoma/self trauma
* Gut stasis/ileus​

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7
Q

How do you perform pre-scrotal castration in small mammals?

A
  • Similar to a dog, except open inguinal ring!
  • Single midline incision cranial to the scrotum and each testicle is pushed up to it.
  • Except, some rodents have a penis that is positioned cranial to the testicles. In these cases a pre-scrotal technique cannot be performed with a single midline incision like in rabbits. ​Instead, two parallel incisions are made slightly lateral to the midline.
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8
Q

How do you perform abdominal castration in small mammals?

A
  • One midline incision going through linea alba (at the cranial pole of the bladder) ​
  • Testicle is pushed up into the abdomen from the scrotum. The testicle is then visualised from the abdomen and exteriorised.
  • The tail of the epididymis is dissected from the everted hemiscrotal sac to exteriorise.
  • Tunic closure is the same with all three techniques.
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9
Q

Why are pre-scrotal and abdominal castration techniques preferred?

A

It reduces the chances of some post op complications because:​
* One incision instead of two.
* Wound is further away from the ground so infection is less likely.
* Less sensitive skin so self-trauma less likely.
* Can suture the skin closed so you can avoid using itchy skin glue.

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10
Q

What clinical signs are associated with reproductive disease in small mammals?

A
  • Changes to body shape, weight loss
  • Pain e.g. gut stasis, reluctance to move or inappetence
  • Discharge or genitalia changes e.g. puss discharge, swollen vulva, crusts, blood.
  • Fur loss/changes
  • Changes to urination e.g. blocked or dysuria (prostate)
  • Swellings/masses e.g. enlarged mammary glands, neoplasia, hernias
  • Prolonged labour e.g. dystocia
  • Behaviour changes e.g. sexual behaviour, aggression.
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11
Q

What are common reproductive conditions in rabbits?

A
  • Testicular neoplasia
  • Cryptorchidism
  • Scrotal trauma
  • Inguinal hernia
  • Uterine adenocarcinoma
  • Pregnancy toxaemia
  • Pseudopregnancy
  • Syphilis
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12
Q

What clinical considerations are important to take into account with uterine adenocarcinomas in rabbits?

A
  • Commonly accepted to have an 80% incidence in does > 4 yrs old.
  • Metastasise by direct contact, blood and lymph
  • Endometrial hyperplasia/endometritis/pyometra might be present
  • Endometrial venous aneurisms causes potentially life-threatening bleeding
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13
Q

What is this an example of?

A

Uterine adenocarcinoma

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14
Q

What causes syphilis in rabbits? How is it spread? What clinical signs are associated?

A
  • Caused by the spirochete, Treponema cuniculi.
  • Spread during copulation and close contact.
  • Crusting lesions on the mucocutaneous junction of nose, lips, eyelids, genitalia and anus.
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15
Q

What are common reproductive conditions in guinea pigs?

A
  • Testicular neoplasia
  • Spermatic plugs
  • Inguinal hernia
  • Orchitis
  • Uterine and ovarian neoplasia
  • Uterine prolapse
  • Pregnancy toxaemia
  • Ovarian cysts
  • Dystocia
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16
Q

How can you diagnose ovarian cysts in guinea pigs? What clinical signs are associated?

A
  • Easily palpated on physical exam
  • Confirm with ultrasound or just with clinical signs.
  • Can be confused with cystic/irregular kidneys or other masses on radiography.

Clinical signs
* Hair loss over flanks without pruritus and normal skin
* Pear shaped
* Behaviour – mounting/aggression
* Lethargy, reduced appetite, discomfort when handled.

17
Q

When does dystocia occur in guinea pigs? Why does it occur?

A

Occurs during the last week of pregnancy generally.

Normal Birth Before 8 months of age
Relaxin from pituitary and endometrium causes fibrocartilage of the pubic symphysis to disintegrate = pubic symphysis widens to 3cm

Abnormal Birth
* If an owner does not breed before 8 months of age the pubic symphysis will be unable to separate = dystocia.
* Parturition is normally in early hours, so if presented during the day = likely dystocia.

Other Causes:
Obesity, large foetuses, and uterine inertia

18
Q

What are the most common reproductive diseases in the chinchilla, gerbil, hamster, rat and hedgehog?

A

Chinchilla: fur ring (paraphimosis), spermatic plugs,
inguinal hernia, uterine neoplasia, pyometra, dystocia.
Gerbil: cystic ovaries, neoplasia.
Hamster: cystic ovaries, neoplasia, pyometra (normal creamy vulvar discharge occurs following oestrous).
Rat: pyometra, neoplasia e.g. mammary adenomas
Hedgehog: pyometra, neoplasia.

19
Q

What are the most common mammary tumours in guinea pigs, rats, mice, gerbils and hamsters?

A

Guinea Pigs:
Benign hyperplasia most likely diagnosis in females.​
Males higher chance of malignancy.​
Rats:
Carcinomas = less than 10% of mammary tumours.​
Fibroadenoma = 85-90% of all mammary tumours. They can become very large, ulcerate, and infiltrate locally, but they rarely metastasise.
Mice and gerbils:
Adenocarcinoma most common, highly malignant and common metastasises, poor prognosis. ​
Fibrosarcoma only account for up to 6% of mouse tumours. ​
Hamster:
Most are benign

20
Q

What are the most common reproductive conditions in ferrets?

A
  • Testicular neoplasia
  • Prostrate hyperplasia
  • Ovarian neoplasia
  • Pyometra
  • Pregnancy toxaemia
  • Persistent Oestrus
  • Hyperadrenocorticism
21
Q

What does persistent oestrus cause in ferrets? What clinical signs are associated? How is it treated?

A
  • About 50% of jills will remain in oestrus unless mated.
  • Prolonged oestrus results in oestrogen-induced bone marrow toxicosis/hyperoestrogenism.
  • Results in pancytopaenia and eventually death.

Clinical signs
* Swollen vulva
* Pale mucus membranes
* Symmetrical bilateral alopecia of flanks and tail
* Petechiae and/or ecchymoses
* Lethargy and anorexia

Treatment for early oestrus
* Stimulate ovulation = hCG
* GnRH agonist implant e.g. Deslorelin (Suprelorin)
* BUT these all take time to work (10-14 days) and bone marrow suppression occurs 4 weeks into season, death occurs at around 8 weeks.

Treatment for severe oestrus
* Blood transfusion may be required
* Ovariohysterectomy BUT must stabilise first and causes HAC risk.

22
Q

What causes ferret hyperadrenocorticism? What clinical signs are associated? How can it be treated?

A
  • NOT cushings (no excess of glucocorticoids).
  • In ferrets HAC is related to sex hormones.
  • Symptoms start in Spring, may regress and return next year.

Suspected Causes:
* >12hrs day light hours (indoor ferrets)
* Early neutering (never seen in entire ferrets)
* Genetic component

Clinical signs
* Symmetrical/bilateral alopecia and ‘rat tail’
* Vulvar swelling in neutered jills
* Sexual behaviour in neutered hobs
* Pruritus
* Dysuria/urinary obstruction in males (prostate)
* Mammary hyperplasia

Medical treatment
- GnRH agonists - desensitises GnRH receptors on the pituitary so less FSH/LH is produced

Surgical treatment
* Left adrenalectomy relatively straightforward.
* Right adrenalectomy more difficult.
* Some advocate partial right adrenalectomy.
* Post-operative medical treatment for HAC required if partial adrenalectomy performed.

23
Q

How would you diagnose a reproductive disease in small mammals?

A
  • Diagnosis can often be made based on clinical exam and history e.g. syphilis, persistent oestrus etc.
  • Blood tests e.g. biochemistry, can useful to rule in or out other differentials. Other body systems specific tests can also help with this e.g. skin scraps and hair plucks when hair loss is involved.
  • Diagnostic imaging is the most useful when diagnosing reproductive diseases e.g. neoplasia, cysts, adrenal gland size etc.
  • Some specific hormone assays are available at exotics labs.
  • Culture and sensitivity is useful for diagnosing/treating infections. #
  • Cytology/Hystology of masses e.g. mammary, uterine, others
24
Q

What are possible treatment options for reproductive diseases in small mammals?

A
  • Ovariohysterectomy e.g. uterine adenocarcinoma, cystic ovaries, pyometra.
  • Caesarean section e.g. dystocia
  • Antibiotics e.g. penicillin for syphilis, open pyometra?
  • Hormonal therapy e.g. GnRH injections for cyctic ovaries, often given after ultrasound guided cyst aspiration.
  • Mammary mass removal +/- cabergoline in rats
25
Q

How can you control reproduction in female ferrets?

A
  • Keep females with a vasectomised hob to induce ovulation.
  • Leave entire and give a yearly ‘jill jab’ to bring females out of season (proligestone injections as soon as they come into heat).
  • Use the hormone implant to chemically neuter on its own (deslorelin).
  • Surgical spay???
26
Q

How can you control reproduction in male ferrets?

A
  • Vasectomised hobs.
  • Use the hormone implant to chemically neuter.
  • Castration???
  • Deslorelin implant (Deslorelin) can chemically neuter males and females for up to 4 years (9.4mg implant).