Neurovascular Interactions

Question 1

Angioneurins

Answer 1

Shared molecular guidance cues that guide both endothelial cells and neurons

Question 2

Examples of angioneurins

Answer 2

• VEGF
• Netrins
• Ephrins

Question 3

Neural tube tissue

Answer 3

dorsal ectoderm

Question 4

What do NPCs secrete

Answer 4

VEGF-A
- recruit ECs to surface of neural tube

Question 5

Signalling from Neural Tube

Answer 5

• Wnt
• VEGF-A

Question 6

Vascularization of the Cerebral Cortex

Answer 6

• vasc. guided migration of GABAergic interneurons
• GABA binds to receptors in migrating INs

Question 7

HIF-1a

Answer 7

• in poorly-vascularised, hypoxic environments it is expressed
• triggers glycolysis
• drives RGCs proliferation

Question 8

Degradation of HIF-1a

Answer 8

Occurs when there is increased vascularization

Question 9

Embryonic BBB

Answer 9

• no astrocytes
• pericytes present
• BBB functional

Question 10

Neonatal BBB

Answer 10

• astrocytes present
• missing elements but BBB still functional

Question 11

Adult BBB

Answer 11

Fully developed

Question 12

Important signalling pathways for the maturation of the neurovascular unit

Answer 12

1) Wnt - B-caterin ( promote BBB genes)
2) PDGF-BB - ECs (pericyte recruitment)
3) Shh - astrocytes (BBB formation)
4) VEGF & IGF-1 - ECs (neurovasc. patterning)

Question 13

Vascularization of the SC

Answer 13

mesoderm angioblasts recruited by NPCs forms PNVP

Question 14

Vascularization of the retina

Answer 14

occurs postnatally

Question 15

Vascular-guided migration of OD precursors

Answer 15

• OLPs guided by vasc.
• secrete Wnt - induce CXCR4
• ECs secrete CXCL12 - attract OLPs

Question 16

Oligodendrocyte maturation

Answer 16

Decrease in Wnt, CXCR4
-> detachment from vasc.