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AN4017 > Axon Growth > Flashcards

Axon Growth Flashcards

1
Q

Rho-GTPases

A

Guidance cues linked to these molecular switches
- regulate actin-binding and MT binding

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2
Q

Repulsive Cues

A

Semaphorin 3A and Ephrin A
- switch on RhoA
- Decreases GC protrusion
- actin depolymerisation

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3
Q

Attractive Cues

A

Neurotrophin and Netrin
- switch on Rac1 and Cdc42
- Increases GC protrusion
- actin polymerisation

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4
Q

What does floor pate secrete

A

Shh and Netrin

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5
Q

Types of GCs

A

Canonical
Non-canonical

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6
Q

Netrin receptors

A

DCC and UNC5 (attractive)

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7
Q

Semaphorins

A

Plexins and Neurophilins (repulsive)

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8
Q

Slits

A

Robo receptors (repulsion)

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9
Q

DCC only netrins

A

attractive cue

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10
Q

DCC and UNC5 netrins

A

repulsive

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11
Q

Netrin (receptor + Rho GTPase)

A

Netrin -> DCC -> Rac

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12
Q

Semaphorin (receptor + Rho GTPase)

A

Semaphorin -> Plexin/ NPN -> Rho

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13
Q

Ephrin (receptor + Rho GTPase)

A

Ephrin -> Robo -> Rho

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14
Q

GPI

A

repulsive guidance molecule (RGM)
- ephrins

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15
Q

Ephrin A

A

repulsive GuidC - GC collapse

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16
Q

Ephrin A and Eph A

A

Ephrin A binding to receptor (Eph A) induce GC collapse - axon CANT move further

17
Q

Nasal & ?

A

Posterior

18
Q

Temporal & ?

A

Anterior

19
Q

Retina Ephrins

A

Eph Bs and Eprhin Bs

20
Q

Wnt3a

A

cooperates with EphB-ephrin B1 to regulate D-V mapping

21
Q

Highest Ephrin A expression

A

Caudal SC

22
Q

Lowest Ephrin A expression

A

Rostral SC

23
Q

Highest Ephrin B expression

A

Medial SC

24
Q

Lowest Ephrin B expression

A

Lateral SC

25
Q

Highest Eph A expression

A

Temporal Retina

26
Q

Lowest Eph A expression

A

Nasal retina

27
Q

Highest Eph B expression

A

Ventral retina

28
Q

Lowest Eph B expression

A

Distal retina

29
Q

Whats crucial for R-C mapping

A

Ephrin A2/5 binding to Eph A3 induces GC collapse

30
Q

Whats crucial for D-V mapping

A

EphrinB binding EphB repels GC - chemorepulsion

AN4017 (5 decks)

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