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BIO304 > Neurotransmitter Table > Flashcards

Neurotransmitter Table Flashcards

1
Q

ACh ionotropic receptor(s)

A

nAChR

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2
Q

ACh metabotropic receptor(s)

A

M1, M3, M5

M2, M4

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3
Q

NE ionotopic receptor(s)

A

N/A

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4
Q

NE metabotropic receptor(s)

A

α2
β1, β2
α1

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5
Q

L-glutamate ionotropic receptor(s)

A

NMDA
AMPA
Kainate

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6
Q

L-glutamate metabotropic receptor(s)

A

mGluR1, mGluR5

mGluR(2, 3, 4, 6, 7, 8)

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7
Q

GABA ionotropic receptor(s)

A

GABA_A

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8
Q

GABA metabotropic receptor(s)

A

GABA_B1, GABA_B2

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9
Q

5-HT ionotropic receptor(s)

A

5-HT_3

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10
Q

5-HT metabotropic receptor(s)

A

5-HT_4, 5-HT_6, 5-HT_7
5-HT_2A, 5-HT_2B, 5-HT_2C
5-HT_1

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11
Q

Dopamine ionotropic receptor(s)

A

N/A

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12
Q

Dopamine metabotropic receptor(s)

A

D1, D5

D2, D3, D4

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13
Q

M1, M3, M5 pathway

A

Gq

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14
Q

M2, M4 pathway

A

Gi/Go

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15
Q

α2 pathway

A

Gi/Go

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16
Q

β1, β2 pathway

17
Q

α1 pathway

18
Q

mGluR1, mGluR5 pathway

19
Q

mGluR(2, 3, 4, 6, 7, 8) pathway

20
Q

GABA_B1, GABA_B2 pathway

21
Q

5-HT_4, 5-HT_6, 5-HT_7 pathway

22
Q

5-HT_2A, 5-HT_2B, 5-HT_2C pathway

23
Q

5-HT_1 pathway

24
Q

D1, D5 pathway

25
Q

D2, D3, D4 pathway

26
Q

ACh marker(s)

A

choline acetyltransferase

27
Q

NE marker(s)

A

dopamine β hydroxylase

28
Q

L-glutamate marker(s)

A

vesicular glutamate transporter

29
Q

GABA marker(s)

A

glutamate decarboxylase

membrane GABA transporter

30
Q

5-HT marker(s)

A

tryptophan hydroxylase 2

PM 5-HT transporter

31
Q

Dopamine marker(s)

A

tyrosine hydroxylase

PM dopamine transporter

32
Q

Effect(s) of Gq pathway

A

Inhibit M-type K+ channels (PLC up, PIP_2 down)
Inhibit SK channels (PLC up, Ca2+ sensitivity down)
Increase cytoplasmic Ca2+ (PLC up, IP3 up, IP3R up)

33
Q

Effect(s) of Gi/Go pathways

A

Activate GIRK channels (Gβγ up)
Inhibit HCN channels (AC down, cAMP down)
Inhibit pre-synaptic Ca_v(2) channels (Gβγ up)

34
Q

Effect(s) of Gs pathway

A 
Inhibit SK channels (AC up, cAMP up)
Increase Ca_v(1) channel activity (AC up, PKA up)
Activate HCN channels (AC up, cAMP up)
35
Q

Effect(s) of nAChR activation

A

EPSP

Pre-synaptic exocytosis

36
Q

Effect(s) of NMDA activation

A

Synaptic plasticity
Activate post-synaptic CaMKII
Awaken ‘silent’ synapses

37
Q

Effect(s) of AMPA activation

A

Excitatory neurotransmission

38
Q

Effect(s) of kainate activation

A

Secondary role in EPSP

39
Q

Effect(s) of GABA_A activation

A

Predominant IPSP in brain

BIO304 (15 decks)

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