Neurotransmitter Table

Question 1

ACh ionotropic receptor(s)

Answer 1

nAChR

Question 2

ACh metabotropic receptor(s)

Answer 2

M1, M3, M5

M2, M4

Question 3

NE ionotopic receptor(s)

Answer 3

N/A

Question 4

NE metabotropic receptor(s)

Answer 4

α2
β1, β2
α1

Question 5

L-glutamate ionotropic receptor(s)

Answer 5

NMDA
AMPA
Kainate

Question 6

L-glutamate metabotropic receptor(s)

Answer 6

mGluR1, mGluR5

mGluR(2, 3, 4, 6, 7, 8)

Question 7

GABA ionotropic receptor(s)

Answer 7

GABA_A

Question 8

GABA metabotropic receptor(s)

Answer 8

GABA_B1, GABA_B2

Question 9

5-HT ionotropic receptor(s)

Answer 9

5-HT_3

Question 10

5-HT metabotropic receptor(s)

Answer 10

5-HT_4, 5-HT_6, 5-HT_7
5-HT_2A, 5-HT_2B, 5-HT_2C
5-HT_1

Question 11

Dopamine ionotropic receptor(s)

Answer 11

N/A

Question 12

Dopamine metabotropic receptor(s)

Answer 12

D1, D5

D2, D3, D4

Question 13

M1, M3, M5 pathway

Answer 13

Gq

Question 14

M2, M4 pathway

Answer 14

Gi/Go

Question 15

α2 pathway

Answer 15

Gi/Go

Question 16

β1, β2 pathway

Answer 16

Gs

Question 17

α1 pathway

Answer 17

Gq

Question 18

mGluR1, mGluR5 pathway

Answer 18

Gq

Question 19

mGluR(2, 3, 4, 6, 7, 8) pathway

Answer 19

Gi/Go

Question 20

GABA_B1, GABA_B2 pathway

Answer 20

Gi/Go

Question 21

5-HT_4, 5-HT_6, 5-HT_7 pathway

Answer 21

Gs

Question 22

5-HT_2A, 5-HT_2B, 5-HT_2C pathway

Answer 22

Gq

Question 23

5-HT_1 pathway

Answer 23

Gi/Go

Question 24

D1, D5 pathway

Answer 24

Gs

Question 25

D2, D3, D4 pathway

Answer 25

Gi/Go

Question 26

ACh marker(s)

Answer 26

choline acetyltransferase

Question 27

NE marker(s)

Answer 27

dopamine β hydroxylase

Question 28

L-glutamate marker(s)

Answer 28

vesicular glutamate transporter

Question 29

GABA marker(s)

Answer 29

glutamate decarboxylase

membrane GABA transporter

Question 30

5-HT marker(s)

Answer 30

tryptophan hydroxylase 2

PM 5-HT transporter

Question 31

Dopamine marker(s)

Answer 31

tyrosine hydroxylase

PM dopamine transporter

Question 32

Effect(s) of Gq pathway

Answer 32

Inhibit M-type K+ channels (PLC up, PIP_2 down)
Inhibit SK channels (PLC up, Ca2+ sensitivity down)
Increase cytoplasmic Ca2+ (PLC up, IP3 up, IP3R up)

Question 33

Effect(s) of Gi/Go pathways

Answer 33

Activate GIRK channels (Gβγ up)
Inhibit HCN channels (AC down, cAMP down)
Inhibit pre-synaptic Ca_v(2) channels (Gβγ up)

Question 34

Effect(s) of Gs pathway

Answer 34

Inhibit SK channels (AC up, cAMP up)
Increase Ca_v(1) channel activity (AC up, PKA up)
Activate HCN channels (AC up, cAMP up)

Question 35

Effect(s) of nAChR activation

Answer 35

EPSP

Pre-synaptic exocytosis

Question 36

Effect(s) of NMDA activation

Answer 36

Synaptic plasticity
Activate post-synaptic CaMKII
Awaken ‘silent’ synapses

Question 37

Effect(s) of AMPA activation

Answer 37

Excitatory neurotransmission

Question 38

Effect(s) of kainate activation

Answer 38

Secondary role in EPSP

Question 39

Effect(s) of GABA_A activation

Answer 39

Predominant IPSP in brain