Neurotransmitter receptors Flashcards
1
Q
C loop receptors
A
Nicotinic ACh and GABA (pentamer)
2
Q
Pore loop receptors
A
Glutamate/ AMPA (tetramer)
3
Q
Subunits of ACh receptor
A
2 alpha, beta, gamma and delta. 4 TM helices - TM2 lines the pore
4
Q
Where does ACh bind
A
Interface between alpha and gamma, and alpha and delta
5
Q
Myasthenia gravis
A
Autoimmune disease causing failure of synaptic transmission at neuromuscular junction
6
Q
How is GABA formed
A
Glutamate decarboxylase used: glutamate —> GABA + CO2
7
Q
How do drugs affect GABA
A
Allosterically enhance its ability to open receptor
8
Q
How is glutamate recycled
A
Astrocytes recycle it via glutamine
