Neurotransmitter Changes in Disease

Question 1

What neurotransmitter is decreased in Parkinson’s disease?

Answer 1

Dopamine

Question 2

What neurotransmitter is decreased in Huntington’s disease?

Answer 2

ACh

Question 3

What neurotransmitter is decreased in dementia disease?

Answer 3

ACh

Question 4

What neurotransmitter is decreased in depression?

Answer 4

NE and 5-HT

Question 5

How do MAO inhibitors treat depression?

Answer 5

decrease destruction of NE and 5-HT

Question 6

How do TCAs treat depression?

Answer 6

block the reuptake of NE and 5-HT

Question 7

How does shock therapy treat depression?

Answer 7

increase NE transmission (which occurs after seizures)

Question 8

What neurotransmitter is affected in schizophrenia?

Answer 8

increased DA

Question 9

What are of the brain is overactive in schizophrenia?

Answer 9

Ventral tegmentum

Question 10

Where is the nucelus basalis of Meynert located?

Answer 10

beneath GP in the substantia innominata

Question 11

What neurotrasmitter is decreased in Alzheimer’s disease?

Answer 11

ACh (also Substance P and somatostatin)

Question 12

Which nucleus is affected by Alzheimer’s disease?

Answer 12

Nucleus basalis of Mynert (75% loss of neurons)