Neurotransmitter Changes in Disease Flashcards
What neurotransmitter is decreased in Parkinson’s disease?
Dopamine
What neurotransmitter is decreased in Huntington’s disease?
ACh
What neurotransmitter is decreased in dementia disease?
ACh
What neurotransmitter is decreased in depression?
NE and 5-HT
How do MAO inhibitors treat depression?
decrease destruction of NE and 5-HT
How do TCAs treat depression?
block the reuptake of NE and 5-HT
How does shock therapy treat depression?
increase NE transmission (which occurs after seizures)
What neurotransmitter is affected in schizophrenia?
increased DA
What are of the brain is overactive in schizophrenia?
Ventral tegmentum
Where is the nucelus basalis of Meynert located?
beneath GP in the substantia innominata
What neurotrasmitter is decreased in Alzheimer’s disease?
ACh (also Substance P and somatostatin)
Which nucleus is affected by Alzheimer’s disease?
Nucleus basalis of Mynert (75% loss of neurons)