Neurotransmitter Changes in Disease Flashcards

1
Q

What neurotransmitter is decreased in Parkinson’s disease?

A

Dopamine

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2
Q

What neurotransmitter is decreased in Huntington’s disease?

A

ACh

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3
Q

What neurotransmitter is decreased in dementia disease?

A

ACh

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4
Q

What neurotransmitter is decreased in depression?

A

NE and 5-HT

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5
Q

How do MAO inhibitors treat depression?

A

decrease destruction of NE and 5-HT

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6
Q

How do TCAs treat depression?

A

block the reuptake of NE and 5-HT

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7
Q

How does shock therapy treat depression?

A

increase NE transmission (which occurs after seizures)

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8
Q

What neurotransmitter is affected in schizophrenia?

A

increased DA

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9
Q

What are of the brain is overactive in schizophrenia?

A

Ventral tegmentum

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10
Q

Where is the nucelus basalis of Meynert located?

A

beneath GP in the substantia innominata

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11
Q

What neurotrasmitter is decreased in Alzheimer’s disease?

A

ACh (also Substance P and somatostatin)

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12
Q

Which nucleus is affected by Alzheimer’s disease?

A

Nucleus basalis of Mynert (75% loss of neurons)

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