Neurotransmission

Question 1

what is co-transmission?

Answer 1

release of multiple NTs from a single synapse

Question 2

What is the process of neurotransmission?

Answer 2

1. neurotransmitter synthesis
2. stored in vesicles
3. degradation of any leaked neurotransmitter
4. action potential dependent release
5. NT binds to postsynaptic receptors
6. NT binds to presynaptic auto-receptors
7. NT deactivated by reuptake or degradation

Question 3

what does depolarisation of presynaptic terminal cause?

Answer 3

causes the opening of voltage gated sodium channels, which leads to calcium entering the cell, inducing NT release

Question 4

Difference between ionotropic and metabotropic transmission?

Answer 4

While ionotropic receptors form an ion channel pore, metabotropic receptors are indirectly linked with ion channels through signal transduction mechanisms, such as G proteins.

Question 5

what can too much excitation cause?

Answer 5

Arousal behaviour
Epilepsy
Death

Question 6

What would happen if there was too much inhibition?

Answer 6

Sleep
Coma
Death

Question 7

what are examples of co-transmission?

Answer 7

ATP
Dynorphin
NO

Question 8

what are auto receptors?

Answer 8

NT acting on own presynaptic terminal to reduce release

Question 9

what are heteroceptors?

Answer 9

NT acting to modulate release other than its own ligand