Neuroscience Methods

Question 1

Functional MRI

Answer 1

Tuned to decipher oxygenated and deoxygenated blood
Can tell you about brain activity- active has more oxygenated blood
So it is blood acting as a contrast agent

Question 2

Position emission tomography PET

Answer 2

Contrast to target specific biological process
Chemical binds to specific molecules

Negative- uses radiation

Question 3

EEG and MEG

Answer 3

Regional brain activity using electrode
Analysis take a long time
Good for detection on epilepsy
Poor spatial resolution

Question 4

ERP

Answer 4

Event related potential

Question 5

MEG

Answer 5

Magnetoencephalography
MEG signals small and hard to detect
Better spatial resolution than EEG

Question 6

TMS

Answer 6

Transcranial Magnetic Stimulation
Induces current in brain tissue which disrupts ongoing activity
Used in research to turn off parts of brain
Hard to target precisely

Question 7

Invasive Methods in Animal Models

Answer 7

Strictly regulated by Home office
Requires clinical justification

3 principles
Replacement
Refinement
Reduction

Question 8

Intercellular recording

Answer 8

Target single cells

Question 9

Extra cellular recording

Answer 9

Record from large number of cells

Question 10

Optogenetics

Answer 10

Light sensitive viral infector to stimulate cells with light