Neuropsych Flashcards
Cause of Huntington’s
AD on chromosome 4
What’s seen in Huntington’s
Cognitive decline, chorea, personality change
Psychiatric disturbances / depression is common
What’s seen in brain of huntingtons
Cerebral atrophy, Decreased GABA -> dopamine hypersensitivity
Management of psychiatric / depression in hungtingtons
Atypical antipsychotics - less motor side effects
What is Wilson’s disease also known as? Cause?
Hepatolenticular degeneration
AR - chormosome 13
What happens in Wilson’s disease? Complications ? Management?
Excess copper deposits in lenticular nuclei
Depression, emotional liability, personality / behavioural changes
Penicillamine
Sx of narcolepsy
Excessive daytime sleepiness, sleep paralysis, hyponogogic hallucinations
Cataplexy - falling suddenly after losing tone (usually die to strong emotions)
How do you treat narcolepsy ?
Stimulants
Methylphenidate / modafinil
What is REM sleep behavioural disorder? Associations? Management?
Individuals act out their dreams -> risk of harm
Parkinson’s, levy body, Gillian barre
Clonazepam & make sleep environment safe
Where do you often find tic disorders ?
Family HX of OCD
Usual presentation of Tourette’s ? Age of onset? Change with age?
Facial tics followed by verbal tics later
Usually at around 7 and reduce by age 18 but often are lifelong
Some names for tics:
Swearing? Rude gestures? Copying what people say/do? Other types?
coprolalia
Copropraxia
Echopraxia
Self injurious
Non-obscene but socially inappropriate Eg shouting bomb at airport
Tourettesis often combined with? Management then?
ADHD - colonidine without stimulant eg atomoxetine
OCD
Management of tic disorders
Antipsychotics for tics
CBT
Psycho education
