Neurophysiology Flashcards
What is the frontal lobe responsible for
executive functioning and personality
what is the parietal lobe responsible for
motor sensor and speech
what is the temporal lobe responsible for
emotions memory and circuits
What is the occipital lobe responsible for
vision, language formation and sensory
what is the cerebellum responsible for
coordination and balance
smooth muscle control
respiratory centers
What kind of behaviors are linked to the prefrontal cortex
- attention, concentration, emotions
- obsessions/compulsions, worry pain, negative symptoms
What kind of behaviors are linked to the nucleus accumbens
delusions, hallucinations, pleasure, euphoria
What behaviors are linked to the amygdala
fear, anxiety and panic
What are the behaviors linked to hypothalamus
sleep-wake, appetite and endocrine
What are the monoamines (neurotransmitters)
serotonin
dopamine
norepinephrine
epinephrine
histamine
what are the amino acid neurotransmitter
glutamate and GABA
What is the other important neurotransmitter
acetylcholine - implicated in Alzheimer’s
What area is affected by dopamine? give the MOA
Substantia Nigra Ventral Tegmental Area
MOA: pleasure / reward neurotransmitter
What are the symptoms of low dopamine and excess
Low:
- blunting, apathy, loss of motivation, increased pain, restless leg syndrome
- neurologic sx - rigidity, shuffle, poor attention span
Excess:
- schizophrenia, excessive movements, pacing, tics, psychosis, anhedonia, anergia, hypersexuality
What area is affected by norepi
Locus coeruleus lateral tegmental area
MOA: excitatory, regulates flight or fight, mood arousal, cognition, motivation increased HR, RR, BP
What are the symptoms of excess and insufficient norepinephrine
Excess:
- ADHD, anxiety, hyperactivity, poor sleep, and depression
Insufficient:
- stress response system, arousal, insomnia, irritability, emotional instability and anxiety
What is the MOA of glutamate? What are the symptoms of excess and insufficiency
MOA: excitatory, learning, memory and alertness
- most prevalent neurotransmitter in body
Excess: panic attacks, anxiety, impulsivity, OCD, depression
Insufficient: agitation, insomnia, memory los, depression, low energy
give MOA of GABA and symptoms of excess/insufficiency
MOA:
- neurochemical - antianxiety, anticonvulsant
Excess:
- excessive sleepiness, memory problems, dizziness, weakness, slurred speech, low BP and RR
Insufficient:
- anxiety, depression, insomnia, poor concentration/focus and seizure disorders
Where is serotonin manufactured in the brain? give MOA, and symptoms of excess/insufficiency
Raphe nucleus
MOA:
- primarily regulates mood, anxiety, appetite, sleep and pain
Excess:
- serotonin syndrome
Insufficient;
- depression, anxiety, insomnia, low pain threshold, carb cravings and constipation
What are Tryptophan foods needed for? What are those food
Needed to help manufacture Serotonin
Foods: oats, lentils, whole wheat, brown rice
Where is Acetylcholine manufactured? What is low levels implicated in?
Brainstem NT center in basal forebrain
Low: implicated with Alzheimer’s and Parkinson’s
Where is Histamine located in the brain? What does it regulate
Tuberomammillary nucleus in the hypothalamus
Regulates sleep-wake switch
