Neuropharmacology Formulary Flashcards
Name the 6 major ASMs
- valproic acid
- topiramate
- levetiracetam (Keppra)
- carbamazepine
- lamotrigine (Lamictal)
- Phenytoin
Name the 2 classes of dementia medications and the drugs within
Cholinesterase Inhibitors (mild-moderate symptoms)
- donepezil
- rivastigmine
N-methyl-D-Aspartate receptor antagonists (moderate-severe symptoms)
- Memantine
Name the 6 major classes of drugs for movement disorders and the drugs within
anti-parkinson’s agents
- levodopa-carbidopa
- amantadine
COMT inhibitors
- tolcapone
- entacapone
dopamine agonists
- pramipexole
- ropinirole
- rotigotine
anticholinergics
- trimexyphenidyl
MAO-B inhibitors
- selgiline
antispastics
- baclofen
Name the 6 classes of MS disease modifying therapies and the drugs within
platform agents
- interferons
- copaxone
anti-CD20 antibody
- ocrelizumab
anti-a4 antibody
- natalizumab
pyrimidine synthesis inhibitor
- teriflunomide
fumarates
- dimethyl fumarate (DMF)(tecfidera)
- diroxmel fumarate (DRF)
- monomethyl fumarate (MMF)
purine antimetabolite
- cladribine
What are some of the abortive therapies for migraines
- sumatriptan
- Ubrogepant
- rimigepant (nurtec)
What are some of the prophylactic therapies for migraine
beta blockers
- propranolol
antidepressants
- nortriptyline
- venlafaxine
ASMs
- valproate
- topiramate
CCRP antagonists
- -mabs (monoclonal antibodies)
gepants
- atogepant
- rimegepant (nurtec)
What are benzodiazepines used for most commonly and what are the two drugs used the most
Status epilepticus
- lorazepam (injected solution, longer duration than diazepam)
- diazepam (injected soln, rectal gel, autoinjector)
What could glucocorticoids be used to treat in neuro conditions
- MS
- medication overuse headache
- temporal arteritis
- meningitis adjunct
(prednisone or methyprednisolone)
What are the hallmarks of cholinergic excess toxidrome
What are the hallmarks of cholinergic deficiency toxidrome
Describe some of the adverse effects of Donepezil
- cholinesterase inhibitor for dementia
- GI, vivid dreams, dizziness, HA, agitation
When is Memantine used in dementia
for more severe cases and usually when there is no/limited professional support
What are the ASMs that are considered to be broad
- levetiracetam
- topiramate
- valproate
- lamotrigine (may precipitate certain myoclonic seizures)
What are ASMs that are considered to be narrow spectrum
- gabapentin
- pregabalin
- lacosamide
- oxcarbazepine
(effective for focal seizures, can worsen certain generalized seizures)
List the 3 ASMs commonly used for generalized seizures
- valproate
- lamotrigine
- levetiracetam
flip this card for a quick review of ASM med choice :)
Describe the black box warning for lamotrigine
Describe the black box warning for valproic acid
What is a hallmark AE for phenytoin
Describe the black box warning for carbamazepine
also aplastic anemia
What is the empiric antimicrobial therapy for adults <50 with bacterial meningitis
What is the empiric antimicrobial therapy for adults >50 with bacterial meningitis
