Neuropharmacology and drug interactions Flashcards
1
Q
Traditional anti-epileptic drugs
A
Diazepam
Phenobarbital
Bromide
Gabapentin
2
Q
Newer anti-epileptic drugs
A
Zonisamide
Levetiracetam
Pregabalin
Imepitoin
3
Q
Difference between midazolam and diazepam
A
Midazolam can be given IM or nasally but not rectally
4
Q
When do you load a drug
A
Clustering
Status epilepticus
Progressive seizures
5
Q
Phenobarbital characteristics
A
T1/2: 40hr Long acting barbituate 20 min to hit the brain Check levels 2 weeks post then every 6 mo Interfere with thyroid levels
6
Q
Biggest worry of phenobarb
A
hepatotoxicity
7
Q
KBr
A
T1/2: 21 days
Steady state in 3 months
Check level every 6-12 months
Do not use in cats
8
Q
Keppra characteristics
A
T1/2: 3hr
Safe
No known side effects
15-20mg/kg
9
Q
zonisamide
A
T1/2: 15hr
Monitor same as Phenobarb
10
Q
Control within 24 hours
A
phenobarb load, keppra, bromide IV load
11
Q
Control within 1 week
A
Phenobarb, zonisamide, keppra
12
Q
Control within one month
A
Phenobarb, zonisamide, keppra
