Neuropharmacology Flashcards
Name the channel blocked by the ff toxins: Omega conotoxin Strychnine Tetrodoxin Apamin
Omega conotoxin Calcium N chanel
Strychnine Glycine receptor
Tetrodoxin Sodium channel
Apamin Potassium channel
Differentiate the role of drugs in movement d/o and depression VS psychosis based on their effect on dopamine.
Dopamine antagonist for psychosis – Clozapine D4, Haloperidol D2
Dopamine agonist for movement d/o – bromocriptine D2 Quinpirole D3
Differentiate the role of drugs in movement d/o and depression VS psychosis based on their effect on dopamine.
Dopamine antagonist for psychosis – Clozapine D4, Haloperidol D2
Dopamine agonist for movement d/o – bromocriptine D2 Quinpirole D3
What is the principal metabolite of:
1 Dopamine
2 NE
1 Homovallinic acid
2 Vanillylmandelic acid
What is the principal metabolite of:
1 Dopamine
2 NE
1 Homovallinic acid
2 Vanillylmandelic acid
Differentiate the role of drugs in depression VS tremor and anxiety based on their effect on dopamine.
Adrenergic agent for depression MAOI (Selegiline) TCA Venlafaxine COMTI (Talcapone)
Adrenergic antagonist for tremor and anxiety B blockers for essential tremor
Differentiate the role of drugs in depression VS tremor and anxiety based on their effect on dopamine.
Adrenergic agent for depression MAOI (Selegiline) TCA Venlafaxine COMTI (Talcapone)
Adrenergic antagonist for tremor and anxiety B blockers for essential tremor
Differentiate the role of drugs in emesis VS migraine based on their effect on dopamine.
Depression – Fluoxetine antagonist at 5HT2c Amitriptyline antagonist at 5HT6
Migraine – Sumatriptan 5HT1B and D
Emesis – Ondansetron antagonist at 5HT3 Metoclopromide agonist at 5HT4
Differentiate the role of drugs in emesis VS migraine based on their effect on dopamine.
Depression – (SSRI) Fluoxetine antagonist at 5HT2c (TCA) Amitriptyline antagonist at 5HT6
Migraine – Sumatriptan 5HT1B and D
Emesis – Ondansetron antagonist at 5HT3 Metoclopromide agonist at 5HT4
Acetylcholinesterase inhibitors can be used to treat which 2 diseases?
Myasthenia gravis and Alzheimer’s dz
What vitamin is necessary to form GABA from glutamate?
B6
Dfx the action of benzodiazepines and barbiturates on GABA A receptor.
Benzos: Increase Cl- channel opening frequency
Barbs: Incrase Cl- channel opening DURATION
What is an example of a GABA site agonist? How about a benzo site antagonist?
Baclofen
Flumazenil!
What GABA analog is used to treat narcolepsy with cataplexy?
gamma hydroxybutyrate
AKA DATE RAPE DRUG
Differentiate the MOA of cocaine and amphetamines as psychostimulants.
Cocaine: Blocks reuptake of monoamines
Amphetamines: also does the same thing but principally PROVOKES PRESYNAPTIC MONOAMINE RELEASE
Give examples of NMDA receptor antagonists
Lamotrigine epilepsy
Memantine AD
Riluzole ALS
What amino acid forms NO?
Arg
Segawa syndrome can be treated with?
L-dopa because it is aka DOPAMINE RESPONSIVE DYSTONIA
Differentiate the MOA of cocaine and amphetamines as psychostimulants.
Cocaine: Blocks reuptake of monoamines
Amphetamines: also does the same thing but principally PROVOKES PRESYNAPTIC MONOAMINE RELEASE
How does MDMA/ ecstasy work?
Amphetamine like effect on serotonin reuptake transporter ergo serotonin efflux into the synapse –> psychostimulant
What is the MOA of PCP Phencyclidine?
noncompetitive NMDA receptor antagonist preventing gluamate induced calcium influx –> dissociative anesthetic
How does nicotine work to produce mild euphoria, increased alertness and muscle relaxation?
Agonist at ACh receptors that increases catecholamines and mesolimbic dopamine
How does buproprion work to help treat smoking withdrawal?
Increases mesolimbic system dopamine
What is the MOA of ethanol?
Facilitates GABA and inhibits NMDA glutamate receptor function
