Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Brain Power: First Aid Neurology > Neuropharmacology > Flashcards

Neuropharmacology Flashcards

You may prefer our related Brainscape-certified flashcards:
The Brain flashcards
1
Q 
Name the channel blocked by the ff toxins:
Omega conotoxin
Strychnine
Tetrodoxin
Apamin
A

Omega conotoxin Calcium N chanel
Strychnine Glycine receptor
Tetrodoxin Sodium channel
Apamin Potassium channel

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Differentiate the role of drugs in movement d/o and depression VS psychosis based on their effect on dopamine.

A

Dopamine antagonist for psychosis – Clozapine D4, Haloperidol D2
Dopamine agonist for movement d/o – bromocriptine D2 Quinpirole D3

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Differentiate the role of drugs in movement d/o and depression VS psychosis based on their effect on dopamine.

A

Dopamine antagonist for psychosis – Clozapine D4, Haloperidol D2
Dopamine agonist for movement d/o – bromocriptine D2 Quinpirole D3

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What is the principal metabolite of:
1 Dopamine
2 NE

A

1 Homovallinic acid

2 Vanillylmandelic acid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What is the principal metabolite of:
1 Dopamine
2 NE

A

1 Homovallinic acid

2 Vanillylmandelic acid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Differentiate the role of drugs in depression VS tremor and anxiety based on their effect on dopamine.

A

Adrenergic agent for depression MAOI (Selegiline) TCA Venlafaxine COMTI (Talcapone)
Adrenergic antagonist for tremor and anxiety B blockers for essential tremor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Differentiate the role of drugs in depression VS tremor and anxiety based on their effect on dopamine.

A

Adrenergic agent for depression MAOI (Selegiline) TCA Venlafaxine COMTI (Talcapone)
Adrenergic antagonist for tremor and anxiety B blockers for essential tremor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Differentiate the role of drugs in emesis VS migraine based on their effect on dopamine.

A

Depression – Fluoxetine antagonist at 5HT2c Amitriptyline antagonist at 5HT6
Migraine – Sumatriptan 5HT1B and D
Emesis – Ondansetron antagonist at 5HT3 Metoclopromide agonist at 5HT4

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Differentiate the role of drugs in emesis VS migraine based on their effect on dopamine.

A

Depression – (SSRI) Fluoxetine antagonist at 5HT2c (TCA) Amitriptyline antagonist at 5HT6
Migraine – Sumatriptan 5HT1B and D
Emesis – Ondansetron antagonist at 5HT3 Metoclopromide agonist at 5HT4

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Acetylcholinesterase inhibitors can be used to treat which 2 diseases?

A

Myasthenia gravis and Alzheimer’s dz

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What vitamin is necessary to form GABA from glutamate?

A

B6

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Dfx the action of benzodiazepines and barbiturates on GABA A receptor.

A

Benzos: Increase Cl- channel opening frequency
Barbs: Incrase Cl- channel opening DURATION

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What is an example of a GABA site agonist? How about a benzo site antagonist?

A

Baclofen

Flumazenil!

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What GABA analog is used to treat narcolepsy with cataplexy?

A

gamma hydroxybutyrate

AKA DATE RAPE DRUG

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Differentiate the MOA of cocaine and amphetamines as psychostimulants.

A

Cocaine: Blocks reuptake of monoamines
Amphetamines: also does the same thing but principally PROVOKES PRESYNAPTIC MONOAMINE RELEASE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Give examples of NMDA receptor antagonists

A

Lamotrigine epilepsy
Memantine AD
Riluzole ALS

13
Q

What amino acid forms NO?

A

Arg

14
Q

Segawa syndrome can be treated with?

A

L-dopa because it is aka DOPAMINE RESPONSIVE DYSTONIA

15
Q

Differentiate the MOA of cocaine and amphetamines as psychostimulants.

A

Cocaine: Blocks reuptake of monoamines
Amphetamines: also does the same thing but principally PROVOKES PRESYNAPTIC MONOAMINE RELEASE

16
Q

How does MDMA/ ecstasy work?

A

Amphetamine like effect on serotonin reuptake transporter ergo serotonin efflux into the synapse –> psychostimulant

17
Q

What is the MOA of PCP Phencyclidine?

A

noncompetitive NMDA receptor antagonist preventing gluamate induced calcium influx –> dissociative anesthetic

18
Q

How does nicotine work to produce mild euphoria, increased alertness and muscle relaxation?

A

Agonist at ACh receptors that increases catecholamines and mesolimbic dopamine

19
Q

How does buproprion work to help treat smoking withdrawal?

A

Increases mesolimbic system dopamine

20
Q

What is the MOA of ethanol?

A

Facilitates GABA and inhibits NMDA glutamate receptor function

Brain Power: First Aid Neurology (10 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions