Neuropathology Flashcards
The biopsy of a 76YOM was conducted. What is the likely cause of these changes?
a) Tumor
b) Infection
c) Trauma
d) Neurodegenerative
e) Anoxic Injury
c) Trauma
Axonal Spheroids in Diffuse Axonal Injury (“Shear Injury”)
56YOM has presents with fever, weight loss, malaise w/ HTN, polyneuropathy and myalgias. A biopsy was done. What is the likely cause of his condition?
a) Dermatomyositis
b) Polymyositis
c) Inclusion Body Myositis
d) Polyarteritis nodosa
e) Nemeline Rod Myopathy
d) Polyarteritis nodosa
Acute vasculitis of epineurial artery; transmural arterial inflammation by polymorphonuclear neutrophils & fibrinoid necrosis
Hx of fever, weight loss, myalgias, malaise w/ HTN, & polyneuropathy -> PAN
What antibodies are associated with this condition?
a) Anti-Hu
b) Anti-Jo
c) Anti-Yo
d) VGKC
e) HBV
e) HBV
Polyarteritis nodosa
30% of patients with PAN have circulating antibodies to HBV
Which medication is likely to cause this?
a) Amphetamine
b) Acetaminophen
c) Keppra
a) Amphetamine
Patient likely died from what problem?
a) Cardiac arrest
b) Amyloid angiopathy
c) Aneurysmal SAH
d) Traumatic Brain Injury
d) Traumatic Brain Injury
Bifrontal contusions w/ slight orange tinge
2ndary to presence of residual hemosiderin-laden macrophages
Patient likely died from what problem?
a) Cardiac arrest
b) Amyloid angiopathy
c) Aneurysmal SAH
d) Traumatic Brain Injury
a) Cardiac arrest
Laminar Necrosis
Seen in hypoxic/ischemic injury
What tumor would you see this in?
What do you see here?
Glioblastoma Multiforme
Pseudopalisading necrosis
& infiltrating high-grade glioma w/ microvascular proliferation
What is standard 1st line therapy in a patient with this pathology on brain biopsy?
Low dose TEMOZOLAMIDE
with radiation therapy
What tumor would you see this in?
What percentage of patient’s survive with this pathology?
Glioblastoma Multiforme
<5%
Patient has a history of seizures and skin abnormalities.
The pathology shows what tumor?
SubEpendymal Giant Cell Astrocytoma (SEGA)
This pathology is associated with what condition?
Tuberous sclerosis
(SubEpendymal Giant Cell Astrocytoma)
Ventricular Hamartomas
Flaky Keratin – Epidermoid Cysts
What is this?
Medulloblastoma
Small blue cell tumor
Associated with “Homer Wright” rosettes (not shown)
What is this?
Ependymoma
Perivascular PSEUDO-rosettes
Biopsy taken from pineal region. What is it?
Germinoma
Biopsy taken from filum terminale. What is it?
Myxopapillary ependymoma
Biopsy taken from cauda equina. What is it?
Myxopapillary ependymoma
Biopsy taken from temporal lobe tumor. What is it?
What is the boxed finding called?
Pleomorphic xanthoastrocytoma or ganglioglioma – these present with with seizures
Pleomorphic glial neoplasm with hypercellularity & lymphocytic infiltrates
Boxed is eosinophilic granular body
Biopsy taken from temporal lobe tumor. What is it?
DNET Dysembryoplastic neuroepithelial tumor
Biopsy taken from a 32 year old female with a calcified mass in the frontal lobe. What is it?
Oligodendroglioma
(Fried Egg appearance)
What is this?
Oligodendroglioma
(Fried Egg appearance)
Biopsy from patient with cognitive issues. What is diagnosis?
Alzheimer’s
Neuritic Plaque
“Gold & Old”
Name 4 conditions would you find this in
Neurofibrillary Tangle
= intraneuronal intracytoplasmic inclusion composed of paired helical filaments
- Alzheimer’s
- Parkinson’s Disease
- PSP
- Down’s
- Parkinson’s Complex of Guam
- Post-encephalitic Parkinsonism
Leptomeningeal melanocytes
