Neuropathic Ulcers Flashcards
What are neuropathic ulcers caused by?
Repeated stress on feet that have diminished sensation
Neuropathy is a common factor in almost all of these wounds.
What is the most common cause of neuropathic ulcers? what are some other causes
Diabetes
List some primary neurological conditions that can cause neuropathic ulcers.
- Spina bifida
- HIV/AIDS
- Multiple sclerosis
- Alcoholic neuropathy
- Herniated discs or spinal abnormalities
- Exposure to toxins
- Vitamin B deficiency
- Renal failure
- Trauma
- Surgery
What percentage of patients with diabetes face the risk of foot ulcers?
- 15% - 20%
80-85% of amputations are preceded by a foot ulcer.
What is the mortality rate after amputation in diabetes patients?
50% in 3-5 years
What are the two main types of diabetes? describe each
- Type 1 (IDDM): often presents in childhood, related to pancreatic islet cells and production of insulin
- Type II (NIDDM): body develops a resistance to effects of insulin (most over 40) 90% of them are overweight
What does hyperglycemia do to wound healing?
Slows the wound healing response
- accelerates atherosclerotic process
- impairs fucntion of neurophils, macrophages, and fibroblasts (proliferation)
- decreased function of cytokines, growth factors
- macro/microvascular impairments
- higher risk of infection becuase of delays in cellular function
- long term = nerve damage to distal nerve fiber
What is glycosylation in the context of diabetes?
- Long-term hyperglycemia leads to glucose binding with proteins to form advanced glycation end products (AGEs)
- This facilitates the formation of irreversible cross-links with collagen = stiffening Connective tissue
Vascular effects of DM
- leading risk factor for CAD, CVD, and PVD
- accelerates rate of atherosclerosis
- causes thickening of basment membrane resulting in decreased delivery of oxygen and nutrients
- less likely to have revascularization if ciruclation problems occur
- patients with DM more likely to have amputation
- smoking can accelerate
What are the key risk factors for neuropathic ulcers?
- Pressure
- Hyperglycemia
- Vascular disease
- Neuropathy
- Mechanical stress
- Abnormal foot function
- Impaired immune response
- Poor vision
- Inadequate education
Peripheral neuropathy: onset and typical progression
-
- gradual onset: painless, or gradual increase in numbness, tingling, burning or pins/needles (dont realize they have neuropathy)
- sudden onset: usually initially painful, then sudden disappearance leaving sensory loss
What are the characteristics of neuropathic ulcers?
- Absent or significantly reduced pain
- position: plantar aspect of foot
- Round, punched-out lesions
- Dry, cracked peri-wound area
- Normal pulses
- Normal or increased temperature
What is the appearance of dry gangrene? cause?
- Dry, black, and shriveled tissue
- no odor
- no discharge
- line of demarcation
- skin above may be health
- caused by lack of nutrition
It is caused by lack of nutrition and has no odor or discharge.
What is the appearance of wet gangrene?
- Painful, purple, swollen tissue
- infected
- malodorous/purulent drainage
- demarcation is ill defined
- caused by excessive moisture
It is caused by excessive moisture and is often infected.
What is the gold standard for assessing sensory integrity in diabetic patients?
Semmes-Weinstein monofilaments