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Landmark Papes in Neurosurgery > Neurooncology > Flashcards

Neurooncology Flashcards

1
Q

5-ALA Stummer

A

increase in contrast-enhancing tumor resection (36% without ALA –> 65% with ALA)
increase in progression free survival 3 years follow-up

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2
Q

Stupp 2005

A

Stupp-Schema: 60 Gy + concomitant + adjuvant temodal
median survival 12 to 14 month

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3
Q

LGG Jakola 2012 + 2017

A

norwegian hospitals (one regions favors surgery, another watchfull waiting)
overall survaval 6 to 15 years

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4
Q

Temodal bei MGMT-Metylierung

A

RTX vs RCTX: median survaval 15 to 22 month
methyliert in 50% d.F.

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5
Q

Avastin Gilbert 2014

A

Erstdiagnose GBM
erhöht progression free survival
don´t improve overall survival

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6
Q

WHO Klassifikation 2021

A

IDH
ATRX
CDKN2A/B
1p19q
TERT(telomerase reverse transcriptase), EGFR-Amplifikation, +7/-10-Kopiezahlmutation
H3-G34, H3-K27
MGMT (methylguanin-methyl-transferase)
+/- Nekrose/Gefäßproliferation
WHO Grad 2/3: Mitotische Aktivität

cIMPACT-NOW (Consortium to inform Molecular and Practival Approached to CNS tumors)

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7
Q

Patchell 1998

A

OP + RTX (Whole brain radiation) better than OP

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8
Q

Simpson Klassifikation

A

I: excision of dural attachement + ggf. bone
II: endothermy of dural attachements
III: invaded sinus or hyperostotic bone
IV: partial removal
V: decompression

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9
Q

Staging AKN nach Samii

A

T1 intrameatal
T2 intra- und extrameatal
T3a filling CPS (cerebellopontine cistern)
T3b reaching the brain stem
T4a compressing brain stem
T4b compressing IVth ventricle

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10
Q

Vecht 1993

A

radiotherapy alone or combined with neurosurgery for single brain metastasis

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11
Q

Perry Protokoll 2017

A

> 65 jährige
40 Gy in 15 Fraktionen + konkomitanter und adjuvanter TMZ

Results:
- median overall survival unabhängig vom MGMT: 7.6 –> 9.3. months
- median progression free survival unabhängig vom MGMT: 3.9 –> 5.3 months
- median overall survival in MGMT-Methylierten: 7.7 –> 13.5 months
- median overall survival in NICHT MGMT-Methylierten:7.9 –> 10

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12
Q

Nordic Clinical Brain Tumour Study Group % Malmström 2012

A

> 60 Jahre
die hypofraktionierte, dosisreduzierte Strahlentherapie 40 Gy anstatt 60 Gy ist genauso effektiv
Compliance in 60Gy Gruppe nur 70%

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13
Q

NOA-08 Trial by Wick 2012

A

Solo Temodal = Solo Radiotherapie
> 65 Jahre
overall survival ca. 9 Monate

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Landmark Papes in Neurosurgery (5 decks)

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