Neurons, neurotransmitters drugs and mental function Flashcards
Lecture 6
Facts about the synapse.
- This is the name of the connection between neurons.
- There are many synapses linking one cell to another.
- when an action potential arrives at an axon terminal, neurotransmitters are released at the synaptic cleft.
- receptors at the postsynaptic neuron responds to the neurotransmitter and generates a graded potential.
Define synaptic cleft..
The synaptic cleft is the space between the presynaptic neuron and the postsynaptic neuron.
Define receptors.
Receptors are specific vesicles.
Explain the process of neurotransmission.
- A message travels from the dendrites through the cell body and to the end of the axon.
- The message causes the chemicals, called neurotransmitters, to be released from the end of the axon
into the synapse. The neurotransmitters carry the message with them into the synapse. The synapse is
the space between the axon of one neuron and the dendrites of another neuron. - The neurotransmitters then travel across the synapse to special places on the dendrites of the next
neuron, called receptors. The neurotransmitters fit into the receptors like keys in locks. - Once the neurotransmitter has attached to the receptors of the second neuron, the message is passed on.
- The neurotransmitters are released from the receptors and are either broken down or go back into the
axon of the first neuron
Define vesicles.
Bag of joy.
They contain 1000’s of neurotransmitter molecules.
Define diffusion in the process of neurotransmission.
Eventually neurotransmitters molecules must be cleared from the synaptic cleft. Some drift away and this is called diffusion.
Sometimes neurotransmitters are taken back up into the presynaptic neuron in a process called….
Reuptake
Synthesis, storage, release, binding and reuptake
The process by which ideas and images are combined and formed into objects of thought or by which objects of consciousness are brought together into meaningful words.
What can have an effect by altering the neurotransmission at synapses?
Drugs
- these drugs can slow it down or speed it up
- you can alter storage of neurotransmitters.
- you can block those receptors
- you can also slow down reuptake of the neurotransmission
Define agonists.
These are drugs that bind to a receptor of a cell and trigger a response by the cell. They often mimics the action of a naturally occuring substance.
What is an indirect agonist?
They enhance the release or action of an endogenous neurotransmitter.
Define antagonist.
This is a drug that binds to the receptor either on the primary site, or on another site, which all together stops the recepetor from producing a response.
Name a few neurotransmitters in the brain.
Serotonin, Dopamine, glutamate, acetylcholine, and horadrenaline
Name a few neurotransmitters in the brain.
Serotonin, Dopamine, glutamate, acetylcholine, and noradrenaline
Name an example of an agonist and antagonist drug.
Nicotine and scopolamine