Neuronal transmission Flashcards

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1
Q

whats a Pacinian Corpuscle ?1

A

pressure sensor found in the skin

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2
Q

outline the structure of a motor neurone ?

2

A
  • large cell body in CNS

- long axon carries AP to the effector

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3
Q

outline the structure of the sensory neurone ? 3

A
  • long DENDRON
  • cell body is just outside the CNS
  • SHORT axon to CNS
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4
Q

Outline the structure of a relay neurone ?

3

A

1-short dendrites (short and fat looking )
2-short axon
3-in CNS

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5
Q

why does having a myelin sheath speed up the transmission of an AP ? 3

A

1-Myelin sheath is made of Schwann cells
2-myleinated neurones = gaps called Nodes of Ranvier (where movement of ions can occur )
3- this makes the impulse jump from node to node = RAPID
4- SALTOTORY CONDUCTION

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6
Q

outline the difference between sensory and motor neurones ?

A

1-

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7
Q

what are the stages of an action potential ?

3

A

1- Depolarisation
2-repolarisation
3-hyperpolarization

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8
Q

resting potential ? —-

threshold potential ?—–

A

1- resting = -60mV

2-Threshold = -10mV

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9
Q

what happens in the membrane when the Na/K pump is in use ? 3

A

-only Na/K pump is working ( 2 K out and 3Na in )
-Na+ channels closed
the concentration of Na is higher outside ( so inside is more negative )

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10
Q

what happens during Depolarisation ? 2

A

1- Na+ channels open and Na+ diffuses into the cell
2-the membrane depolarises = has a less negative potential ACROSS the membrane !
3- IT reaches threshold = the VOLTAGE GATED NA+ channels open due to positive feedback and many more na+ seep out into the cell so the potential is now +
4-+ 40mv is reached

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11
Q

what happens during Repolarisation ? 4

A

1- Na+ channels close / K+ channels open
2-K+ channels move out of the cell making the outside more positive and the inside more negative
3-a more negative potential is gradual reached .
4-it can overshot and become hyperpolarized so the pump will help restore this !

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12
Q

what direction does k+ diffuse ?

na+ channel movement of na + ?

A
  • K+ channels allow the k+ to diffuse from high to low concentration= Always from INSIDE –> OUTSIDE !
    -Na+ will always move from the outside to the inside of a cell .( higher concentration outside of the cell )
  • Natural setting : more k+ inside cell and More Na+ outside cell.
    (remember that outside of cell is salty (more na+ on outside ))
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13
Q

whats the refractory period and why is needed?

A
  • at the end of an AP the K+ and Na+ ions are in the wrong places!
  • there is k+ on the outside of the cell and Na+ on the inside of the cell !
  • so to fix this we have a pump ! Na/K pump !
  • this also requires some time = REFRACTORY period !
  • this also makes sure that the AP goes in the right direction
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14
Q

whats it called when one neurone branches to many neurones? 1

A
  • spatial summation (many to one ) (one to many)

- (several Generator potentials cause AP)

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15
Q

whats is called when one neurone keep sending several APs ?

A
  • temporal summation

bang bang bang

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16
Q

whats summation ?1

A
  • occurs when the effects of several excitatory post-synaptic potentials (EPSPS) or generator potentials (GPs) are added together !
17
Q

whats habituation ? 3

A
  • after repeated stimulation a synapse may run out of vesicles containing the neurotransmitter !
  • synapse = fatigued
    -nervous system no longer responds to stimulus
    =Habituated
18
Q

outline transmission across a synapse ? 7

A

1- Ap arrives at pre synaptic neurone
2-Voltage gated Ca2+ open and ca2+ diffuses in
3-this causes vesicles with neurotransmitter to move to the presynaptic membrane
4-acetylcholine is released VIA EXOCYTOSIS
5-acetycoline diffuses across the cleft and binds to receptor site on NA+ CHANNEL ON POST SYNAPTIC MEMBRANE = conformational change
6-Na+ opens! and Na+ floods into the cell
7-GP created and if sufficient GPs are created then an AP will occur

19
Q

What are local currents ?

A

Explain