NEUROMUSCULAR & MUSCLE RELAXANTS

Question 1

are those drugs that induce temporary paralysis of skeletal muscles

Answer 1

muscle relaxants

Question 2

known as Glyceryl guaiacolate, is used as an adjunct to anesthesia to produce muscle relaxation and restraint for short procedures.

Answer 2

Guaifenesin

Question 3

central acting muscle relaxant that is used as an adjunct to rest, physical therapy in the treatment of musculoskeletal injury, muscular
spasm associated with tetanus and metaldehyde or strychnine poisoning.

Answer 3

methocarbamol

Question 4

• cause muscle relaxation when applied around muscle fibers.
• However, they are not used for the muscle relaxant effect.

Answer 4

lidocaine

Question 5

• (CNS drugs) can relax skeletal muscles but they are not used routinely for the sole purpose of muscle relaxation.

Answer 5

general anesthetics

Question 6

there are no clinically useful muscle relaxants in this group.

Answer 6

motor nerve terminal

Question 7

2 drugs responsible for preventing the release of Ach; thus it causes muscle relaxation.

Answer 7

1. Botulinus toxin
2. Aminoglycoside antibiotics

Question 8

muscles acting on this site are most clinically
useful muscle relaxants.

Answer 8

Acetylcholine receptors in motor end plate

Question 9

decreases sarcoplasmic free calcium concentration by promoting its uptake
into the sarcoplasmic reticulum
- useful in malignant hyperthermia.

Answer 9

dantroline

Question 10

compete with Ach for cholinergic receptors in the end plate

Answer 10

Nondepolarizing neuromuscular blocking drugs

Question 11

– noncompetitive blocks of cholinergic
receptors in the end plate. There is sustained stimulation leading to receptor fatigue and
muscle paralysis

Answer 11

Depolarizing neuromuscular blocking drugs