Neuromuscular Dz's Flashcards
What is the most common disorder of neuromuscular transmission?
Myasthenia gravis
Describe the pathophysiology of Myasthenia gravis?
Autoimmune disorder of the post-synaptic neuromuscular junction
The receptors of the neuromuscular junction are blocked by antibodies –> Blocks Acetylcholine
The most common symptom of neuromuscular disease is what…
WEAKNESS
Myasthenia gravis occurs in what PT demographics most commonly?
Females: 2nd to 3rd decade
Males: 7th to 8th decade
What is the typical clinical presentation of myasthenia gravis?
May have enlarged thymus Fluctuating fatigue (worsens as day goes on, hot temps, stress, infxn
What clinical studies could you order to definitively Dx Myasthenia Gravis in a suspected PT?
Serology of:
~ Acetylcholine receptor antibodies
~ Muscle-specific receptor tyrosine kinase (MuSK)
Tensilon (Edrophonium)
EMG (Electromyogram) –> assess Nerve/muscle function