Neuromuscular Diseases (5) Flashcards
Timing of neuromuscular diseases
sudden- vasucular disorders( Stroke)
1-14 days- poliomyelitis, Guillain barre syndrome, porphyria, polyarteritis
slowest- disease of the mm itself
lab tests done in myopathies
CK * Na, K, cl, hco3 (électrolytes) creatinine (damage to mm cells) Urea (due to pro breakdown) Liver tests
Main two tests for myopathies
Serum creatine kinase
Serum or urine myoglobin
Rhabdomyolysis causes
Primary mm injury- trauma, alcohol
Hypoxia- ischarmia, carbon monoxide poisoning
- inf
- drugs (statins)
rhabdomyolysis lab checks
urine blood/myoglobin
serum creatine kinase
serum myoglobin
Early on in heat stroke what is one of the first things to be decreased
calcium
MS symtoms + lab
mm weakness due to decreased neuromuscular signal transmission blurred vision judgement impaired emotionally labile variable course
lab- check for antibodies againt myelin
Peripheral neuropathy causes
chronic kidney failure diabetes mellitus alcoholism vit b12 def drugs
myasthenia graves s/s, tests
mm weakness on repetitive tasks
w>m
tests- Serum antibodies to acetyl choline receptors
Trauma to mm lab tests
Lab tests- Serum CK, serum or urine myoglobin
What lab tests are best at assessing the extent of mm damage caused by exercise (3)
- CK
- Aspirtate amino transferase
- Lactate dehydrogenase
what is paraneoplastic syndrome as associated s/s
mm weakness often accompainies neoplasia
- -paratharsia
- -pain
- -sensory loss
- -absent tendon reflexes
- -prox mm weakness
Dermatomyositis/polymyositis- causes, s/s
autoimmune/inf possible
40-60 years of age w>m
facial ooedema, erythema/pink scaling eruption in dermatomyositis
Dermatomyositis/polmyositis lab tests
ESR or serum CRP increased
Serum alpha2 and gamma globulins increased
Serum ANA (SLE tests tests neg)
What does the dermatomyositis rash look like
localized or diffuse erythema
maculopapular eruption
heliotrope discoloration over dosum of figner jts etc
itching possible
Periodic paralysis/potassium probs- triggers (4), lab tests
Exercise, food, stress, cold
lab tests- Serum and urine K during attack falls
alcoholic myopatht s/s, lab tests
mm weakness
cramps
swelling
tenderness
lab tests– serum creatine kinase increased
serum and urine myoglobin increased
how does alcohol affect mm physiology (3)
- substate use increases (ATP not regen)
- NADH increases so pyruvate is converted to lactate
- Acetate is produced and atp used up
Alcoholic myopathy lab monitoring for abstinese (3)
Serum GGT (increases w alcohol intake) Serum carbohydrate deficient transferrrib Serum methanol
elevated thyroid stimulating horomone is an indication of
hypothyroidism
what is teteny
low calcium
Chronic fatigue syndrome causes, s/s
Trigger may be Epstein barr virus, viral encephalitis, herpes
- debilitating disease for more than 6 months
- extreme ehaustion
