neuromuscular diseases Flashcards
features of periheral neuropahty
distal weakness
easrly wasting
reduced reflexes
sensory can be involved
2.5% prealent increacing in age
causes: charcot marie tooth
aquired/ inflammatory. metabloic, b12 deficincy.
myasthenia gravis
psotis, double vision, dysarthria
fatiguability, fluctuant weakness
young and old bimodal dist
ginetic dispositoin, autoimmune triggers
Ix: EMG, serum acetylcholine recptor antobody testing.
Rx: pred for immunosuppression
pyridostigmine- boost amount of ach
thymectory (for thymoma)
ivig- for chrisis.
MND
progressive weakness, speech and breathing problems, tounge wasting
mix upper and lower motor signs
no sensory signs
brisk reflexes.
ALS most common. pls- slow progression.
assoc with FTDementia
goldcoast criteria for diagnosis.
Rx: incurable
tofersen is new might work