multiple sclerosis Flashcards

1
Q

what is ms

A

inflammatory disorder of the central nervous system

immune cells from blood enter CNA

demylinate aoxons- loose neurons

relapses

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2
Q

what categorisation is there

A

relapsing remitting
secndary progresive

primary progressive
benign

measure disabililty using expanded disabililty scale- 1-10.

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3
Q

what causes MS

A

3:1 women to men.

some ginetic involvement, glandular fever at early age. (EBV)- cant have ms without EBV.

link with vitamin d- 5000u a day reccomended

demeyelination– remyelination–scarring– some defecit.

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4
Q

diagnosis of ms

A

mcdonal criteria

clinical symptoms

and

dissemination in space (MRI- 2 areas in brain)

and time (>1 month)- CSF oligoclonal bands counts (been some inflam in the past).

abscence of other explaination.

optic neuritis doesnt count, but should raise suspicion alot.

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5
Q

RX of MS

A

relapse: 0.5 methylpred daily for 5 days. oral (if can self care can go home)

or

1g IV 3-5/7
plasma exchenge if big remission, but very rare.

long term treatments
Disease modifying theray- interferon beta /galtiramer etc.
or highly effective ones- ocrevus.

or stem cell.

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6
Q

typical attack locations

A

optic neuritis

transverse myelitis.

brainstem- ataxia, diplopia, vertigo speech etc. mri brain for this.

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