multiple sclerosis

Question 1

what is ms

Answer 1

inflammatory disorder of the central nervous system

immune cells from blood enter CNA

demylinate aoxons- loose neurons

relapses

Question 2

what categorisation is there

Answer 2

relapsing remitting
secndary progresive

primary progressive
benign

measure disabililty using expanded disabililty scale- 1-10.

Question 3

what causes MS

Answer 3

3:1 women to men.

some ginetic involvement, glandular fever at early age. (EBV)- cant have ms without EBV.

link with vitamin d- 5000u a day reccomended

demeyelination– remyelination–scarring– some defecit.

Question 4

diagnosis of ms

Answer 4

mcdonal criteria

clinical symptoms

and

dissemination in space (MRI- 2 areas in brain)

and time (>1 month)- CSF oligoclonal bands counts (been some inflam in the past).

abscence of other explaination.

optic neuritis doesnt count, but should raise suspicion alot.

Question 5

RX of MS

Answer 5

relapse: 0.5 methylpred daily for 5 days. oral (if can self care can go home)

or

1g IV 3-5/7
plasma exchenge if big remission, but very rare.

long term treatments
Disease modifying theray- interferon beta /galtiramer etc.
or highly effective ones- ocrevus.

or stem cell.

Question 6

typical attack locations

Answer 6

optic neuritis

transverse myelitis.

brainstem- ataxia, diplopia, vertigo speech etc. mri brain for this.