Neuromuscular blockers Flashcards
What are the two types of neuromuscular blocking agents (NMBAs)
Depolarizing (noncompetitive)
Nondepolarizing (competitive)
What is an exaple of a depolarizing NMBA and what is it used for?
Succinylcholine
Used for rapid sequence intubation
What are some intermediate acting nondepolarizing NMBAs?
Atracurium
Cistracurium
Rocuronium
Vercuronium
When are NMBAs indicated?
Intubation
Mechanical ventilation synchrony (improve pt compliance w/ vent)
What must you have when starting/during NMBA therapy?
Adequate sedation and analgesia
What is a risk with succinylcholine?
Malignant hyperthermia
What are the steroid-based NMBAs?
Pancuronium
Rocuronium
Vecuronium
What are benzylisoquinolinum compound NMBAs?
Atracurium
Mivacurium
What is a side effect of mivacurium and what is the risk with this?
Histamine release
Hypotension
What are some drugs that negatively interact with NMBAs?
Steroids Aminoglycosides CCB Beta blockers Furosemide
What do you have to do to fight resistance to NMBAs?
Increased bolus and infusion doses to induce and maintain paralysis
How do you monitor NMBA therapy?
Train of four (peripheral nerve stimulator)
Ultimately, NMBAs do what?
Provide sedation AND analgesia
