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Pharm > Anti-platelet drugs > Flashcards

Anti-platelet drugs Flashcards

1
Q

What are some examples of anti-platelet drugs?

A

Glycoprotein IIb/IIIa inhibitors

ADP receptor antagonists

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2
Q

What are some examples of glycoprotein (GP) IIb/IIIa drugs?

A

Eptifibatide

Abciximab

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3
Q

How is eptifibatide administered?

A

IV

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4
Q

For what is eptifibatide given?

A

ACS

PCI/stent

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5
Q

What is the GP IIb/IIIa drug abciximab?

A

A chimeric monoclonal antibody

*human/murine

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6
Q

What is a concern about abciximab and what is the result of this?

A

Numerous adverse effects

Little used

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7
Q

What is an example of an ADP antagonist?

A

Ticlopidine

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8
Q

What adverse effects caused the the black box warning for ticlopidine?

A

Neutropenia
Agranulocytosis
Thrombotic thrombocytopenia purpura
Aplastic anemia

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9
Q

What is ticlopidine reserved for?

A

Patients who are intolerant to aspirin or have failed aspirin therapy

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10
Q

What is a common ADP antagonist?(think Katy’s lectures)

A

Clopidogrel (plavix)

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11
Q

What is clopidogrel?

A

A prodrug converted to an unidentified active metabolite

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12
Q

What is the ultimate result of clopidogrel?

A

Preventing platelet aggregation

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13
Q

What affect does clopidogrel have on PPIs?

A

Decreased activity of PPI by CYP 2C19 inhibition

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14
Q

What affect do PPIs have on clopidogrel?

A

Increased risk of re-stenosis

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15
Q

What ADP antagonist is considered more effective than clopidogrel and ticlopidine?

A

Prasugrel

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16
Q

What is an advantage prasugrel has over clopidogrel?

A

Less inhibition by PPIs

17
Q

What is a classic platelet antagonist?

18
Q

What is the MOA of aspirin?

A

Inhibits platelet aggregation by acetylation of ADP receptor

19
Q

How long does acetylation via aspirin last?

A

The life of the platelet

20
Q

What are some adverse effects of aspirin?

A

GI bleed

Tinitis

21
Q

What do we consider with adverse effects of aspirin and how can we avoid them?

A

Benefits vs. adverse effects

Minimal at low doses

22
Q

What type of aspirin do you give for an acute MI?

A

Normal -> not baby aspirin

23
Q

What kind of drug is dipyridamole?

A

Platelet antagoinst

24
Q

What are the mechanisms of dipyridamole?

A

Platelet aggregation inhibitor

Vasodilator

25
Q

Under what condition do you combine dipyridamole with another drug and what drug do you combine it with?

A

When pt has a mechanical heart valve

Warfarin

26
Q

When is dipyridamole used as a diagnostic agent?

A

In CAD

Persasntine stress test

Pharm (32 decks)

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