neuromuscular block agents m&M 200

Question 1

depolarizing muscle relaxants are _________

Answer 1

compet agonists

Question 2

ND muscle relax are

Answer 2

compet antagonists.

Question 3

chronic decrease in ach release ——-(stimulat compensatory increase in ACH receptors within muscle membrane and promote expression of the immature ACH receptor) EXAMPLE of the condition

Answer 3

Muscle denervation injury

Question 4

response in muscle depol injury by depolerizers and non depolarizers.

Answer 4

exaggerated response to Sux and resistance to ND.

Question 5

Downregulation example of the condition

Answer 5

Myasthenia Gravis

Question 6

response to Downregulation

Answer 6

resistance to Depolarizer and increased sensitivity to ND.

Question 7

Drugs interfere w opening and closing of Sodium cannels of Ach receptor.Ach receptor- Lipid membrane interface is an imp site of action. Examples are

Answer 7

Inhaled anesthetics, Ketamine , Local anesthetic.

Question 8

Drugs physically plugs up channal

Answer 8

In Lab, Neostigmine , Antibiotics,cocaine,quinidine

Question 9

Prejunctional receptors are blocked .What will happen to TOF

Answer 9

delayed response.

Question 10

The only time Neostigmine reverses sux block

Answer 10

phase 2 block and suficint time pass after sux

Question 11

first NM ralxant bind agt

Answer 11

sugammadex

Question 12

cemical degrdn, ultrashort act NM blk agt

Answer 12

Gantacurium

Question 13

cholineestrase inhib can inc succ induced NMB. how?

Answer 13

By increasing Ach at NMJ and inhib Sux metab by psudoch

Question 14

hydrolyzed in plasma and liver by psuedocholin, which drug

Answer 14

Sux

Question 15

Fade , grad diminution of evoked response durng prolonged or rpt nerve stim. Signifcans

Answer 15

ND blk or Phase 2 blk odf Sux.

Question 16

Prejunctional receptors are blocked by NMB. Called

Answer 16

Fade

Question 17

Sust tet stim or double burst stim is fav than TOF or rept twitches, To detrmine

Answer 17

adeq of recov or block , response Fade due to prejunctinal and post jntional dec of Ach. recept block and dec of ach.

Question 18

to inc the evoked resp to subseq twitch in teatnic stim due to Ach surge

Answer 18

post tet potrntiation

Question 19

No POST TET pot , Fade w TOF , condiotion

Answer 19

phase 1 depol by sux

Question 20

constant but diminshd resp to TOF, tetany , or DBS but absent post tet potrntion. Condition

Answer 20

Phase 1 depol Sux