neuromuscluar junction ache inhibitors Flashcards
1
Q
edrophonium what does it do
A
inhibits ach breakdown
true competative inhibitor
rapid dissociation
used in diagnosis of myasthenia gravis
2
Q
what is used to diagnose myasthenia gravis
A
edrophonium
3
Q
what drug is a true competative inhibitor
A
edrophonium
4
Q
physostigmine what does it treat
A
myasthenia gravis
glaucoma
5
Q
what can cross the blood brain barrier
A
physostigmine
6
Q
physostigmine what can it bind too
A
can bind to anionic site of ache
7
Q
physostigmine how does binding happen
A
serine attacks the carbonyl group of physostigmine
intermidiate is stable and thus takes long to hydrolysis
8
Q
what is the other drug that inhibits ache
A
neostigmine
