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pharmacology > autonomic nervous system 3 > Flashcards

autonomic nervous system 3 Flashcards

1
Q

adrenergic synapses

A

noradren

co transmitters: ATP and NPY

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2
Q

Noradrenaline is a what and what is it formed from

A

catecholamine

made from tyrosine

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3
Q

NT synthesis what happens to tyrosine to get nor and dopamine

A

turned into dopa by tyrosine hydroxylase
the dopa to dopamine by dopa decarboxylase
then dopamine to noradren by dopamine - beta- hydroxylase

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4
Q

noradrenaline inhibits what

A

inhibits TH tyrosine hydroxylase

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5
Q

rate limiting step is

A

tyrosine to dopa

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6
Q

drugs affecting NT synthesis

alpha- methyl tyrosine what does it affect

A

inhibits tyrosine hydroxylase

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7
Q

drugs affecting NT synthesis

what affects dopa decarboxylase

A

disulfiram cu2+ chelators

L-dopa - treatment parkinsons increases dopamine

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8
Q

NT storage what stores them

A

VMAT

vesicular monoamine transporter

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9
Q

drugs affecting NT storage

A

reserpine

depletes Noradren stores previously used to treat hypertension cause serve depression

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10
Q

NT release how does it happen

A

ca influx
vesicle fusion with membrane
nt release

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11
Q

how is NT regulated without drugs

A

auto-inhibitory feedback

some evidence of positive feedback via Beta 2 Receptor

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12
Q

Neurotransmission regulated by Drugs

what are the indirectly acting sympathomimetics

A

amphetamine
tyramine
ephedrine

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13
Q

amphetamine what does it do

A

displaces Nad from vesicle
increasing Nad transmission
cns stimulant

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14
Q

tyramine what does it do

A

increases Nad release from vesicle

no clinical use

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15
Q

ephedrine

A

beta agonist
increases Nad transmission
nasal decongestant

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16
Q

Nt reuptake and degradation

what does this

A 
NET- noradrenaline transporter
or 
EMT - extraneuronal monoamine transporter
then VMAT packaging
or degraded by MAO
or catechol-o-methyl transferase COMT
17
Q

breaking down only happens is Nor is

A

in excess

18
Q

MAO where is it located and what forms does it contain

A

located in mitochondrial surface
2 distinct isoforms MAO-A or B
found in Nor terminals or in liver/intestines

19
Q

MAO what does it do

A

converts catecholamines to aldehyde
can act of 5-ht and dopamine
controls levels of Nor in CNS terminals

20
Q

COMT where is it located

A

located in cytosol

not found in nor terminals but found in adrenal medulla

21
Q

COMT what does it do

A

converts catecholamines to methoxylation

22
Q

drugs that act on reuptake and degradation

A

MAOIs
amphetamine, tyramine, ephedrine
methylphenidate, atomoxetine

pharmacology (13 decks)

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