Neurology Short Case Flashcards
Causes of Horner’s syndrome (6)
- Carcinoma of lung apex (usually SCC)
- Neck - thyroid malignancy, trauma
- Carotid arterial lesion - carotid aneurysm or dissection, peri-carotid tumour, cluster headache
- Brainstem lesion - lateral medullary syndrome, syringobulbia, tumour
- Retro-orbital lesions
- Syringomyelia (rare)
Causes of anosmia (bilateral) (7)
- Upper respiratory tract infection (most common)
- Meningioma of the olfactory groove (late)
- Ethmoid tumours
- Head trauma (including cribriform plate fracture)
- Meningitis
- Hydrocephalus
- Congenital - Kallman’s syndrome (hypogonadotrophic hypogonadism)
Causes of anosmia (unilateral) (2)
- Meningioma of the olfactory groove (early)
2. Head trauma
Causes of absent light reflex but intact accomodation reflex (4)
- Midbrain lesion (eg. Argyll Robertson pupil)
- Ciliary ganglion lesion (eg. Adie’s pupil)
- Parinaud’s syndrome
- Bilateral anterior visual pathway lesions (bilateral afferent pupil deficits)
Causes of absent convergence but intact light reflex (2)
- Cortical lesion (eg. cortical blindness)
2. Midbrain lesions (rare)
Causes of constricted pupils (6)
- Horner’s syndrome
- Argyll Robertson pupil
- Pontine lesion (often bilateral, but reactive to light)
- Narcotics
- Pilocarpine drops
- Old age
Causes of dilated pupils (6)
- Mydriatics, atropine poisoning or cocaine
- Third nerve lesion
- Adie’s pupil
- Iridectomy, lens implant, iritis
- Post trauma, deep coma, cerebral death
- Congenital
Cause and signs (5) of Adie’s syndrome
Cause: lesion in the efferent parasympathetic pathway
Signs:
- Dilated pupil
- Decreased or absent reaction to light (direct and consensual)
- Slow or incomplete reaction to accomodation with slow dilation afterwards.
- Decreased tendon reflexes
- Patients are commonly young women
Causes of Argyll Robertson pupil (4)
Cause: lesion of the iridodilator fibres in the midbrain
- Syphilis
- Diabetes mellitus
- Alcoholic midbrain degeneration (rarely)
- Other midbrain lesions
Signs of Argyll Robertson pupil (4)
- Small, irregular, unequal pupil
- No reaction to light
- Prompt reaction to accomodation
- If tabes associated, decreased reflexes
Features of papilloedema (6)
- Optic disc swollen without venous pulsation
- Acuity normal (early)
- Colour vision normal
- Large blind spot
- Peripheral constriction of visual fields
- Usually bilateral
Features of papillitis (6)
- Optic disc swollen (in retrobulbar neuritis and old papillitis the optic disc becomes pale)
- Acuity poor
- Colour vision affected (particularly red desaturation)
- Large central scotoma
- Pain on eye movement
- Onset usually sudden and unilateral
Causes of papilloedema (7)
- Space - occupying lesion (causing raised intracranial pressure) or a retro-orbital mass
- Hydrocephalus (associated with large ventricles)
- Idiopathic intracranial hypertension
- Hypertension (grade IV)
- Central retinal vein thrombosis
- Cerebral venous sinus thrombosis
- High cerebrospinal fluid protein level - Guillain-Barre syndrome
Causes of hydrocephalus (2)
- Obstructive (block in the third ventricle, aqueduct or outlet to fourth ventricle - eg. tumour)
- Communicating
- increased formation - choroid plexus papilloma
- decreased absorption - tumour causing venous compression, subarachnoid space obstruction from meningitis
Causes of idiopathic intracranial hypertension (6)
- Idiopathic
- Contraceptive pill
- Addison’s disease
- Drugs - nitrofurantoin, tetracycline, vitamin A, steroids
- Lateral sinus thrombosis
- Head trauma
Causes of optic atrophy (5)
- Chronic papilloedema or optic neuritis
- Optic nerve pressure or division
- Glaucoma
- Ischemia
- Familial - retinitis pigments, Leber’s disease, Friedreich’s ataxia
Causes of optic neuropathy (6)
- Multiple sclerosis
- Toxic - ethambutol, chloroquine, nicotine, alcohol
- Metabolic - vitamin B12 deficiency
- Ischaemia - diabetes mellitus, temporal arteritis, atheroma
- Familial - Leber’s disease
- Infective - infectious mononucleosis
Causes of cataract (6)
- Old age (senile cataract)
- Endocrine - diabetes mellitus, steroids
- Hereditary or congenital - dystrophia myotonica, Refsum disease
- Ocular disease - galucoma
- Irradiation
- Trauma
Causes of ptosis with normal pupils (9)
- Senile ptosis (common)
- Myotonic dystrophy
- Fascioscapulohumeral dystrophy
- Ocular myopathy eg. mitochondrial myopathy
- Thyrotoxic myopathy
- Myasthenia gravis
- Botulism, snake bite
- Congenital
- Fatigue
Causes of ptosis with constricted pupils (2)
- Horner’s syndrome
2. Tabes dorsalis
Cause of ptosis with constricted pupils (1)
- Third nerve lesion
Clinical features of a third nerve palsy (3)
- Complete ptosis (partial ptosis with incomplete lesions)
- Divergent strabismus (eye ‘down and out’)
- Dilated pupil unreactive to direct or consensual light and unreactive to accomodation
Central causes of third nerve palsy (5)
- Vascular (brainstem infarction)
- Tumour
- Demyelination
- Trauma
- Idiopathic
Peripheral causes of third nerve palsy (4)
- Compressive lesions (next card)
- Infarction - diabetes mellitus, arteritis (pupil usually spared)
- Trauma
- Cavernous sinus lesions
Peripheral causes of third nerve palsy (compressive) (5)
- Aneurysm (usually posterior communicating artery)
- Tumour causing raised intracranial pressure (dilated pupil occurs early)
- Nasopharyngeal carcinoma
- Orbital lesions - Tolosa-Hunt syndrome (superior orbital fissure syndrome - painful lesion of the 3rd, 4th, 6th, and 1st division of 5th cranial nerves)
- Basal meningitis
Clinical features of a sixth nerve palsy (3)
- Failure of lateral movement
- Affected eye is deviated inwards in severe lesions
- Diplopia - maximal on looking to the affected side; the images are horizontal and parallel to each other; the outermost image is from the affected eye and disappears on covering this eye (this image is also usually more blurred)
Causes of bilateral sixth nerve palsies (4)
- Trauma (head injury)
- Wernicke’s encephalopathy
- Raised intracranial pressure
- Mononeuritis multiplex
Causes of unilateral sixth nerve palsies - central (4)
- Vascular
- Tumour
- Wernicke’s encephalopathy
- Multiple sclerosis (rare)
Causes of unilateral sixth nerve palsies - peripheral (4)
- Diabetes, other vascular lesions
- Trauma
- Idiopathic
- Raised intracranial pressure
Causes of jerky nystagmus - horizontal (3)
- Vestibular lesion (fast phase away from lesion)
- Cerebellar lesion (fast phase towards lesion)
- Internuclear ophthalmoplegia (MS or brain stem infarct)
Causes of jerky nystagmus - vertical (2)
- Brain stem lesion
- upbeat nystagmus suggests lesion in floor of the fourth ventricle
- downbeat nystagmus suggests a foramen magnum lesion - Toxic - phenytoin, alcohol (may be multidirectional)
Causes of pendular nystagmus (2)
- Retinal (decreased macular vision) - albinism
2. Congenital
Clinical features of supranuclear palsy (5)
- Loss of vertical upward and/or downward gaze
- Both eyes affected
- Pupils often unequal
- No diplopia
- Reflex eye movements intact
Clinical features of Steele-Richardson-Olszewski (PSP) (6)
- Loss of vertical downward gaze first, later vertical upward gaze and finally horizontal gaze. Saccades are impaired before pursuit. Vergence is lost early
- Pseudo bulbar palsy
- Long-tract signs
- Extrapyramidal signs
- Dementia
- Neck rigidity
Clinical features of Parinaud’s syndrome (3)
- Loss of vertical upward gaze
- Convergence-retraction nystagmus on attempted convergence
- Pseudo Argyll Robertson pupils
Causes of Parinaud’s syndrome (8)
Central
- Pinealoma
- Multiple sclerosis
- Vascular lesions
Peripheral
- Trauma
- Diabetes mellitus
- Other vascular lesions
- Idiopathic
- Raised intracranial pressure
Causes of fifth nerve palsy (central) (4) - pons, medulla, upper cervical cord
- Vascular
- Tumour
- Syringobulbia
- Multiple sclerosis
Causes of fifth nerve palsy (peripheral) (3) - posterior fossa
- Aneurysm
- Tumour (skull base eg. acoustic neuroma)
- Chronic meningitis
Causes of fifth nerve palsy (trigeminal ganglion) (2) - petrous temporal bone
- Meningioma
2. Fracture of the middle fossa
Causes of fifth nerve palsy (cavernous sinus) (3) - associated 3rd, 4th and 6th nerve palsies
- Aneurysm
- Thrombosis
- Tumour
Causes of fifth nerve palsy (other) (4)
- Sjogren’s syndrome
- SLE
- Toxins
- Idiopathic
Causes of seventh nerve palsy (upper motor neurone) (2)
- Vascular
2. Tumour
Causes of seventh nerve palsy (lower motor neurone) (4 regions)
- Pontine (often associated with V, VI)
- vascular
- tumour
- syringobulbia
- multiple sclerosis - Posterior fossa
- acoustic neuroma
- meningioma - Petrous temporal bone
- Bell’s palsy
- Ramsay Hunt syndrome
- otitis media
- fracture - Parotid
- tumour
- sarcoid
Causes of bilateral lower motor neurone facial weakness (5)
- Guillain-Barre syndrome
- Bilateral parotid disease (eg. sarcoidosis)
- Mononeuritis multiplex (rare)
- Myopathy
- Neuromuscular junction defects
Causes of sensorineural deafness (7)
- Degeneration (presbycusis)
- Trauma (eg. high noise exposure, fracture of the petrous temporal bone)
- Toxic (eg. aspirin, alcohol, streptomycin)
- Infection (eg. congenital rubella, congenital syphilis)
- Tumour (eg. acoustic neuroma)
- Brain stem lesions
- Vascular disease of internal auditory artery