Neurology - Extrapyramidal diseases Flashcards
NEU - 5.1
Which is NOT the sign of Parkinson’s disease?
A) resting tremor
B) a rigidity
C) hyperreflexia
D) postural instability
ANSWER
C) hyperreflexia
EXPLANATION
The hyperreflexia is not the sign of Parkinson’s disease.
NEU - 5.3
Which territory of the brain is first of all involved in Parkinson’s disease?
A) frontal cortex
B) striatrum
C) pallidum
D) substantia nigra
ANSWER
D) substantia nigra
EXPLANATION
The main neuropathological finding in Parkinson’s disease is the progressive degeneration of the dopaminergic neurons in the sunstantia nigra.
NEU - 5.4
Typical sign(s) of Huntington’s disease:
A) blepharospasm
B) areflexia
C) pyramidal signs
D) dementia
ANSWER
D) dementia
EXPLANATION
In Huntigton-chorea beside of the hyperkinesia, the subcortical type of dementia is the most typical neuro-psychiatrical sign.
NEU - 5.5
The form of the inheritance of Wilson’s disease:
A) autosomal recessive
B) autosomal dominant
C) inherited with the X-chromosome
D) it is not hereditary
ANSWER
A) autosomal recessive
EXPLANATION
The Wilson’s disease is inherited by autosomal recessive way.
NEU - 5.6
The parkinsonic tremor:
A) resting type
B) the intended movements provoke it
C) the lack of tremor excludes the Parkinson’s disease
D) it doesn’t stop during sleep
ANSWER
A) resting type
EXPLANATION
The resting tremor is one of the cardinal motor sings in Parkinson’s disease, which in the starting phase doesn’t provoked by action, intention, and stops during sleep.
NEU - 5.7
The postural instability in Parkinson’s disease:
A) it is typical from the onset of the disease
B) it appears in the Hoehn–Yahr III. stage
C) it doesn’t happen
D) the Parkinson’s disease is excluded because of this sign
ANSWER
B) it appears in the Hoehn–Yahr III. stage
EXPLANATION
The postural instability never appears in the starting phase of Parkinson’s disease. If there are early falls down, these could be a marker of multiple system atrophy (MSA).
NEU - 5.8
What kind of medication could be effective in essential tremor?
A) anticholinergic drugs
B) vasodilatators
C) dopamin agonists
D) propranolol
ANSWER
D) propranolol
EXPLANATION
The adequate therapy of the essential tremor are β-blockers and primidon.
NEU - 5.9
Which drug could cause toxic Parkinsonian syndrome?
A) anilin
B) zinc
C) MPTP (heroin derivate)
D) bensol
ANSWER
C) MPTP (heroin derivate)
EXPLANATION
The regular drug usage in the population of the american young people provoked Parkinsonian –syndrome. The MPTP was a component of these drugs. Since that time the MPTP became the experimental model of provoking the parkinsonism.
NEU - 5.10
The relative amount of acetyl-choline in the striatum in Parkinson’s disease is:
A) constant
B) elevated
C) decreased
D) there is no acetyl-choline in the striatum
ANSWER
B) elevated
EXPLANATION
The relative increment of the amount of the acetyl-choline is the consequence of the lack of dopamine, which has inhibitory effect. This causes the unbalance of these neurotransmitters.
NEU - 5.11
The typical sign of the Wilson’s disease is:
A) dystonia
B) doll’s eye phenomenon
C) signs of meningeal irritation
D) the lack of the abdominal skin reflex
ANSWER
A) dystonia
EXPLANATION
In Wilson’s disease there could be any type of dyskinesias, we can see first of all torsinon type of dystonia.
NEU - 5.12
The striatonigral degeneration is:
A) a form of the multisystem atrophy
B) brain infarct
C) pathological calcification
D) the cerebellar degeneration is an obligatory sing of it
ANSWER
A) a form of the multisystem atrophy
EXPLANATION
The striatonigral degeneration, the olivopontocerebellar atrophy and the Shy-Drager-syndrome are the three forms of the MSA. These three subtypes constitute one pathological entity, when there are inclusion bodies in the degenerated oligodendroglial cells.
NEU - 5.13
The intentional tremor:
A) the basic sign of the Parkinson’s disease
B) it caused by the damage of the dentato-rubro-thalamic pathway
C) it is decreased, or constant during the intended movements
D) it could be treated with the antiparkinsonic drugs
ANSWER
B) it caused by the damage of the dentato-rubro-thalamic pathway
EXPLANATION
The intentional tremor is the consequence of a cerebellar lesion, definitely the lesion of the dentato-rubro-thalamic pathway.
NEU - 5.14
The prevalence of the Parkinson’s disease is approximately:
A) 1–2 patients per 100 000 people
B) 5–10 patients per 100 000 people
C) 10–20 patients per 100 000 people
D) 100–200 patients per 100 000 people
ANSWER
D) 100–200 patients per 100 000 people
EXPLANATION
The prevalence of Parkinson’s disease is the same all over the World, under 65 years there are 100-200 patients in 100 000 people.
NEU - 5.15
The focal dystonias (e.g.: blepharospasm):
A) typical in adulthood
B) typical in childhood
C) there are a lot of patients in both of these groups
D) inherited with the X-chromosome
ANSWER
A) typical in adulthood
EXPLANATION
Focal dystonias can be seen in adulthood
NEU - 5.16
The signs of the Parkinson’s disease:
1) rigidity
2) ataxic gait
3) hypersalivation
4) saccadic speech
A) 1st, 2nd and 3rd answers are correct
B) 1st and 3rd answers are correct
C) 2nd and 4th answers are correct
D) only 4th answer is correct
E) all of the answers are correct
ANSWER
B) 1st and 3rd answers are correct
EXPLANATION
According to the international diagnostic criteria, the rigor and salivation are typical for Parkinson’s disease among the answers listed here.