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Year 4 PAEDS > Neurology > Flashcards

Neurology Flashcards

1
Q

What % of children end up having a febrile convulsion and over what age range is it most common?

A

4%

Happens in children aged 6m-6y but most common below 2y

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2
Q

What are the most common sources of infection that might lead to febrile convulsion?

A

UTI
Otitis media
URTI - or tonsillitis

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3
Q

How does a febrile seizure present?

A

The parent might not know the child is febrile beforehand
Seizures usually tonic-clonic in nature and last <15mins
There is usually post-octal drowsiness (no longer than hour)
Might be some apnoea and peripheral cyanosis

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4
Q

What % of febrile convulsions recur?

A

30-50% but children will grow out of them by the time they are 6y

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5
Q

What features make febrile conclusions atypical?

A

More than 1 in same febrile illness
Lasting longer than 15mins
Focalising features (unilateral or sensory)
If the child is found to have a cerebral infections (e.g. meningitis this is NOT a FebCon)

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6
Q

Is there an increased risk of epilepsy with febrile convulsion?

A

FebCon IS NOT THE SAME AS EPILEPSY (important to remember this)
If the child has a family hx of epilepsy there chance of developing it after having a Febrile seizure is 1% (Up from 0.5% background risk)

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7
Q

How should you advise a parent to manage a febrile seizure in the future?

A

Time it + film it if possible
Remove anything from around the child that they could harm themselves with
Place a pillow under their head
DO NOT place anything in their mouth
Do NOT restrain them
If it continues for longer than 15 minutes then call and ambulance

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8
Q

How could you consider managing febrile convulsion in secondary care?

A

If not stopping after 5 minutes consider intervention
BUCCAL MIDAZOLAM 0.5mg/kg
Wait 10 mins - if not resolves
IV LORAZEPAM 0.1mg/kg
If still seizing after 30 mins they are in STATUS and need to consider senior anaesthetic advice and phenytoin

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9
Q

Can you give anti-pyretics in febrile convulsions?

A

PARACETAMOL does NOT reduce the rate of febrile seizure (no relation between degree of fever and seizure)- however still encourage parents to give it as it will make the child more comfortable

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10
Q

What are some examples of seizure mimics in the paediatric patient?

A

Breath holding attacks
Syncope
Psychologically determine paroxysmal events

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11
Q

What is a breath-holding attack and when does it occur?

A

Can be self-induced by tantrum or occur after excessive crying
Children can fall to floor and can sometimes twitch on way down/just after which can appear like a seizure (RELFEX ANOXIC SEIZURE)

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12
Q

What is syncope and when does it occur?

A

Just fainting, often vasovagal episodes just like in adults
Usually occurs from 7m onwards
Might happen more with certain RFx: head banging, fright, sudden standing, hair brushing
Usually there is an AURA
Might also be MYOCLONIC JERKY making it seem like seizure (usually lasts <20s making you think it’s not seizure)

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13
Q

What is characteristic of physiologically determined paroxysmal events?

A

Thrashing movements that wax or wane (e.g. pelvic thrusting)
Slumping to the floor in dramatic fashion
The child might have some sort of gain from situation (e.g. parent’s attention)
Rapid return to normal

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14
Q

Other than FebCon and mimics what are some other causes of seizure in children?

A 
Meningitis or encephalitis 
Head trauma 
Metabolic e.g. DKA 
Tumours 
Toxins e.g. cocaine 
Cardiac arrhythmias 
GORD EVENTS (pulling up of legs can seem like seizure)
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15
Q

What is cerebral palsy?

A

CP is a lifelong disorder of movement and coordination caused by damage to the brain before, during or shortly after birth
- There are many different causes CP just describes the disorder

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16
Q

What are some pre-natal causes of CP?

A

Congenital malformations (poor migration of brain cells)
Poor, pre-natal myelination of nerve cell fibres
Prenatal TORCH infections (toxoplasmosis, cytomegalovirus, rubella and herpes)

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17
Q

What are some peri-natal causes of CP?

A

Usually hypoxia is the cause - either asphyxia or major haemorrhage leading to hypo perfusion of brain tissue

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18
Q

What are some post-natal causes of CP?

A

Non-functional connections between brain cells (sustained hypoxia, infection or trauma)
Hyperbilirubinaemia or neonatal stroke

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19
Q

Is CP more common in pre-term babies?

A

YES

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20
Q

What is the most common movement type in CP and what are some sub-types of this?

A 
SPASTIC CEREBRAL PALSY 
Described depending on which limbs are affected...
MONOPLEGIC (just one limb - RARE)
DIPLEGIC (one half of body usually LEGS)
HEMIPLEGIC (either R or L)
QUADRIPLEGIC (all 4 limbs)
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21
Q

What is spasticity?

A

This is a STRETCH RELATED RESPONSE

Velocity-dependent increased resistance to stretch

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22
Q

What are some signs and symptoms of spastic cerebral palsy? Think about each joint

A

Clasp-knife spasticity - initially lots of resistance then snaps down
Ankle plantar flexion and usually valgus or varus foot deformity
HIP - flexion, internal rotation, limited adduction
WRIST - flexed and pronated
ELBOW: flexed
SHOULDER: adducted

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23
Q

What is choreoathetosis ?

A

This is another movement disorder associated with CP
It is caused by problems at basal ganglia and causes jerky movements
Greatly increased tone while awake and slightly reduced in early stages of sleep

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24
Q

What is ataxia?

A

Another form of CP
Children have striking loss of balance in their early years
Hypoxia and ischaemia known causative factors for this

25
Q

How do we rate the severity of CP?

A

Using the GMFCS

Gross Motor Function Classification System

26
Q

How might CP present to you?

A 
Unusual fidgeting common
Asymmetry or paucity of movement
Unusually floppy or unusually rigid 
GROSS MOTOR DELAY (not sitting by 8 months, not walking by 18 months or asymmetry of hands early on)
Feeding and nutrition - pseudo bulbar palsy (can't control facial movements)
Many Chesty LRTIs
Bladder infections and incontinence
Bowel constipation
27
Q

How would you investigate/diagnose CP?

A

Might be able to of from hx alone - always go back and ask about hx of prematurity or birth complications

MRI - if spastic CP suspected get it of pyramidal tract and if it is another form of CP get it of basal ganglia

28
Q

How should CP be managed?

A

MDT input: Drs, specialist nurse, physio, OT, SALT
Focussed around improving posture and movement - stretching exercises, orthoses, wheelchair, botulinum toxin
BACLOFEN - can be given to relax muscles
SELECTIVE DORSAL RHIZOTOMY (SDR)

Treat sequelae (seizures, constipation, nutrition and psychological)

29
Q

What other neurological deficits are children with CP likely to develop?

A 
Hearing and vision
Speech 
Learning difficulties 
Epilepsy 
Nutritional impairment 
Psychiatric
30
Q

What are some examples of primary headaches that chidden can get?

A

Migraines
Tension headaches
Cluster headaches
Cough/exertion headache

31
Q

How does a migraine present?

A 
Aura? (only 10%) can last from 1-72hrs
Can be pustule over frontal/temporal area 
Can be associated with GI sx 
Photophobia 
Can be familial and cyclical
32
Q

How does a tension-type headache present?

A

Feels like a tight band across forehead

Usually no other symptoms

33
Q

What are some examples of secondary headaches?

A

These are headaches that are due to underlying pathology

Usually caused by increased ICP or SOL

34
Q

What is a basilar type migraine?

A

This is a headache that is associated with vomiting and more cerebellar type symptoms such as DANISH

35
Q

Describe a characteristic headache associated with a SOL?

A

Worse when lying down
Associated with vomiting
Might be change in mood, personality or educational performance

36
Q

What other symptoms might you find with a child with a SOL?

A 
Visual field defects 
Cranial nerve defects  
Diplopia 
Gait abnormalities 
Changes in character or personality 
Growth failure 
Papilloedema
37
Q

What can we do to manage headaches?

A

Provide reassurance and basic analgesic advice to most
Give some anti-emetics (prochlorperazine and metoclopramide) if necessary
SUMATRIPTAN is a serotonin agnost licensed for use in children over 12

38
Q

What is hydrocephalus?

A

This is when there is an abnormality meaning the CSF that is constantly being produced cannot be cleared from the brain and builds up.
In children because the suture lines have not formed this means the fluid can collect and stretch the cranium
***if this happens in utero this will mean a C-S is required

39
Q

What are some congenital causes of hydrocephalus?

A

Congenital malformation of outflow foramina of the fourth ventricle - DANDY-WALKER SYNDROME
Arnold-Chiari malformation of the cerebral aqueduct
Aqueduct stenosis

40
Q

What are some other causes of hydrocephalus?

A

Failure to resorb
SAH
Meningitis

41
Q

How is hydrocephalus treated?

A

A SHUNT is formed between the ventricular system and the peritoneum - excess fluid drains into the abdomen

42
Q

What is plagiocephaly?

A

Abnormal shaping or flattening on one side of baby’s head

43
Q

What causes plagiocephaly?

A

Usually it is caused by the baby lying on their back for long periods of time and this is not concerning
Can happen in utero
Can happen due to craniosynostosis - premature fusion of suture lines

44
Q

Who is plagiocephaly more common in?

A

Prems
Twins
Breech babies

45
Q

What are the two forms?

A

Synostotic - two or more sutures in baby’s head have fused

Non-Synostotic - no fusion

46
Q

How should plagiocephaly be managed?

A

Encourage allowing the baby to play on its stomach

Physical therapy and orthotics can help where conservative management fails

47
Q

What is a neuroblastoma and who does it occur in?

A

It is a tumour of neural crest tissue that occurs in the adrenal medulla and sympathetic nervous system

Most common in children aged under 5

48
Q

How will children with neuroblastoma present?

A

Usually with abdominal mass that is coming from adrenal medulla
Technically tumour can occur anywhere down sympathetic chain
Usually the symptoms that are presenting are of metastatic disease
Bone pain
Myelosuppression
Weight loss
Malaise

49
Q

How would we make/confirm a diagnosis of neuroblastoma?

A 
RAISED URINE CATECHOLAMINES (VMA, HVA)
Biopsy
Bone marrow sampling 
Bone scan 
Meta-iodobenzyl guanidine
50
Q

What is the prognosis for neuroblastoma?

A

Depends on age of presentation

BUT if they are older than 1 year then their prognosis is very poor - usually because metastasis rate is so high

51
Q

What is spina bifida?

A

FAILURE OF FUSION OF SPINAL ARCH
This happens to differing degrees
Poor formation of neural tube in first 28 days post-conception

52
Q

What should be done to prevent spina bifida?

A

Prophylactic folic acid supplementation (400mcg) or 5mg in women with epilepsy or diabetes

53
Q

How does spina bifida present?

A

Can range from incidental finding on x-ray to very obvious external abnormality
May have large lump of neural tissue on back
Or may have skin changes such as unusual hairiness, skin dimpling or pigmentation over the spine
- ALWAYS CHECK DURING NEWBORN EXAM
Bladder or lower limb dysfunction

54
Q

What level of the spine in spina bifida most concerning at?

A

If lesion is above L3

55
Q

How should we investigate spina bifida?

A

MRI and USS

Always assess power and tone of the legs as well as bladder and bowel function

56
Q

What are the different types of spina bifida?

A

Meningocele - spinal cord approx flush with skin level and there is good covering of skin
Myelomeningocele - this is when there is a considerable portion of neural tissue external also

57
Q

How is spina bifida managed?

A

SURGICAL SOON AFTER BIRTH
Check for hydrocephalus
Refer to physio for management of power and tone
Indwelling catheter
Check renal function, HTN and UTI regularly
Monitor for scoliosis

58
Q

What is West Syndrome?

A

A type of epilepsy that commonly presents between 4-8 months of age
Repeated extension and flexion attacks up to 50 times

Year 4 PAEDS (18 decks)

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