Neurology Flashcards

1
Q

What is decerebrate rigidity and where is the lesion

A

Extension of all limbs and opisthotonus

Lesion rostral brainstem

Usually stuporous or comatose

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2
Q

What is decerebellate rigidity and where is the lesion

A

Hyper extension of TLs and opisthotonus

Lesion: rostral part of cerebellum

Mentation normal
May be episodic or postural

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3
Q

What is schiff-Sherrington and where is the lesion

Is it prognostic

A

Hyperextension of thoracic limbs and paralysis of pelvic limbs

Lesion: thoracic or cranial lumbar spine

Not prognostic

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4
Q

Ataxia - where could the lesion be

A

Spinal or peripheral nerve

Vestibular

Cerebellar

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5
Q

Grading of spinal lesions

A
Grade 1 - no deficits
Grade 2 - paresis, ambulatory
Grade 3 - paresis, non-ambulatory
Grade 4 - paralysis
Grade 5 - no pain sensation
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6
Q

Postural reactions

A
Paw position
Hopping
Hip sway
Wheelbarrow
Extensor postural thrust
Placing responses
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7
Q

Cutaneous trunci where is the lesion

A

Wherever reflex stops between t3-l3 or if unilaterally absent there is a severe brachial plexus lesion

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8
Q

Horners syndrome lesion

A

Sympathetic supply to eye

Midbrain- cervical spinal cord - brachial plexus(t1-t3) - tympanic bulla - eye

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9
Q

What does the patellar reflex assess?

A

L4-s6 spinal segments and the femoral nerve

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10
Q

Menace response tests what?
Afferent
Efferent

A
Afferent:
Retina
Optic nerve
Contralateral optic tract
Contralateral forebrain

Efferent:
Contralateral forebrain
Ipsilateral cerebellum
Facial nerve (brainstem)

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11
Q

Problems seen with forebrain disease

A

Altered mental status (disorientation, depression)
Contralateral blindness (reduced menace but normal PLR)
Normal gait
Circling (ipsilateral, head turn, head pressing, pacing)
Decreased postural responses and proprioception in contralateral limbs
Seizures
Hemineglect syndrome
Behavioural change

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12
Q

Problems seen with brainstem lesions

A
Cranial nerve deficits (III-XII)
Depression/stupor/coma
Paresis of all or ipsilateral limbs
Possible vestibular signs
Possible decerebrate rigidity
Decreased postural response in ipsilateral or all limbs
Respiratory / cardiac abnormalities
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13
Q

Problems seen with cerebellar lesions

A
Normal mentation
Ipsilateral menace deficit with normal vision
Possible vestibular signs
Possible decerebellate rigidity
Intention tremors
Wide based stance
Truncal ataxia
Hypermetria (can only be cerebellar)
Proprioceptive deficits ipsilateral limbs
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14
Q

Vestibular nystagmus which direction is the lesion in relation to head tilt and nystagmus

A

Head tilt towards lesion

Fast phase away from lesion

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15
Q

Problems seen with myopathies

A

Generalised weakness and or exercise intolerance (stiff stilted gait,neck ventroflexion)

No proprioceptive deficits
Usually normal spinal reflexes unless significant muscle atrophy
Variable muscle tone and bulk

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16
Q

If menace and plr are absent where is the lesion

A

Either within the eye eg retina, Bilateral optic nerves or optic chiasm

17
Q

Which nerve is required for extensor tone (and ability to bear weight) in the forelimb and hindlimbs

A

Forelimb- radial

Hindlimb - femoral and tibial

18
Q

What is seen on MRI in cats with FIP

A

Periventriculitis

19
Q

What is seen in CSF with cats with FIP

A

Increased protein (50-350 mg/dl) with a pleocytosis consisting neutrophils, lymphocytes and macrophages

20
Q

How to diagnose masticatory myositis

A

Raised level of 2M antibodies that are specific for this condition

21
Q

Diagnosis of myositis

A

Myalgia and muscle atrophy
High creatinine kinase levels 2000-3000
Electrodiagnostic tests and muscle biopsy revealing inflammatory cell infiltration (macrophages and lymphocytes)

22
Q

Contraindications to CSF sampling

A

Increased ICP
Clotting problems
Chiari-like malformations
AA instability or trauma

23
Q

Normal CSF characteristics

A

< 5 WBC/ul
No RBCs
Protein < 30-45mg/dl

24
Q

What are spinal reflexes like with myopathies?

What about proprioceptive deficits?

A

Normal

No deficits (unless extremely weak and unable to move limbs - otherwise neuro exam should be normal)

25
Q

Treatment of acute polyradiculoneuritis

A

Physiotherapist
Supportive care

Prognosis fair but if respiratory Ryan function it is poor

Recovery to ambulatory over several weeks

26
Q

Clinical signs of acute polyradiculoneuritis

A

Acute and rapidly progressive
PLs affected over 2-3D then progresses to TLs
Non-ambulatory tetraparesis (may affect respiratory muscles)
Mental status unaffected
No autonomic signs

27
Q

Diagnose of myopathy

A

EMG first followed by NCV to test peripheral nerve function as EMG cannot differentiate myopathy from neuropathy

Muscle and/or nerve biopsies

CSF analysis (polyradiculoneuritis)

Advanced imaging with some myopathies

28
Q

Consequences of a tail pull injury

A

Urinary incontinence (retention)

Paralysis of tail

Faecal incontinence and loss of anal tone

29
Q

A hyperextended hock is typical of damage to what nerve

A

Sciatic

30
Q

A flaccid dropped tail is typical of damage to what nerve?

A

Caudal/coccygeal nerve

31
Q

How to test pudendal nerve function

A

Perineal reflex

32
Q

Prognostic indicators in cats with CNS lymphoma

A

Cats with paresis and FeLV infection are considered to have a poor prognosis

33
Q

Difference between SRMA and MUO on CSF analysis

A

SRMA has a neutrophilic pleocytosis and MUO has a mononuclear pleocytosis or no changes

34
Q

Antibiotic choice for discospondylitis

A

Beta- lactam and a flouroquinolone but ideally based on culture results (CSF, blood or urine)

Treat for 6-8 weeks

35
Q

Sites of CSF collection

A

Cisterna magna or l5-l6 in dogs l6/7 in cats