Neurology Flashcards
How does cranial nerve XII deficit present?
Weakness on the ipsilateral side and protrusion of the tongue toward the affected side - CN XII = Hypoglossal nerve
How does cranial nerve XI deficit present?
Weakness with turning of head - CN XI = Spinal accessory nerve
How does cranial nerve X deficit present?
Focal: Aphonia dysphagia dysarthria - Systemic: (cardiac and GI most affected) - CN X = Vagus nerve
How does cranial nerve IX deficit present?
Dysphagia and dysarthria - CN IX = Glossopharyngeal nerve
How does cranial nerve VIII deficit present?
Positional vertigo - Tinnitus - Rarely hearing loss - CN VIII = Vestibulocochlear nerve
How does cranial nerve VII deficit present?
Complete or partial paralysis of the face - CN VII = Facial nerve
How does cranial nerve VI deficit present?
Medial turning of affected eye - CN VI = Abducens nerve
How does cranial nerve V deficit present?
Anesthesia of the forehead - Corneal drying - Decreased salivation - CN V = Trigeminal nerve
How does cranial nerve IV deficit present?
Vertical diplopia - CN IV = Trochlear nerve
How does cranial nerve III deficit present?
Outward and downward deviation of the eye - Ptosis of the eyelid - Dilation of the ipsilateral pupil in complete palsy -CN III - Oculomotor nerve
How does cranial nerve II deficit present?
Partial or complete blindness - CN II = Optic nerve
How does cranial nerve I deficit present?
Loss of smell - CN I = Olfactory nerve
Medication added to cholinesterase inhibitors in the treatment of Alzheimer’s?
Memantine
First line class of drugs used to treat Alzheimer
cholinesterase inhibitors
Beta amyloid plaques and neurofibrillary tangles?
Alzheimer’s findings on autopsy
Most common form of dementia?
Alzheimer’s disease
Slowly progressive impairment of memory reasoning and orientation?
Dementia
Common causes of delirium?
Medical illness - Sun downing - Substance intoxication or withdrawal - Sepsis
Short term/temporary confusion or altered mental state?
Delirium
Acute meningitis associated with a purpuric rash?
Meningococcal meningitis (N. Meningiditus)
Most common cause of Reye Syndrome?
Salicylates (e.g. aspirin Pepto Bismol etc.)
Rapidly progressive encephalopathy with hepatic dysfunction?
Reye Syndrome
In what disorder are negri bodies found in neurons?
Rabies
What are the most common symptoms of encephalitis?
Fever - Headache - Nausea - Vomiting - Altered mental status
Most common severe complication of measles?
Encephalitis
Viral meningitis is associated with predominance of what cell in the CSF?
Lymphocytes (Note: bacterial meningitis has neutrophils)
Name the sign: Inability to allow full extension of knee when hip is flexed 90 degrees.
Kernig’s sign
Name the sign: Flexion of hips on passive neck flexion.
Brudzinski’s sign
What disorder are fever, headache, neck stiffness with initially normal brain function most concerning for?
Meningitis
Treatment for Cerebral Palsy?
Speech physical and occupational therapy - Aspiration precautions - Anti-spasmodics
Non-progressive disorder characterized by spastic rigidity and slow writhing movements?
Cerebral Palsy
Treatment of acute exacerbations of MS?
Glucocorticoids
What ophthalmology disorder is seen frequently in patients with multiple sclerosis (MS)?
Optic Neuritis
Most common demyelinating disorder mainly in women age 20-50?
Multiple Sclerosis
Radiating electrical sensation down the spine with neck flexion seen in patients with multiple sclerosis?
Lhermitte’s phenomenon
Patients with Myasthenia Gravis have antibodies to what?
Acetylcholine receptors
Treatment for Myasthenia Gravis?
Pyridostigmine
Diagnostic test for Myasthenia Gravis?
Edrophonium (Tensilon) test
Proximal to distal motor weakness?
Myasthenia Gravis
Treatment for Guillain-Barre?
Intravenous immunoglobulins - Plasma exchange
Typical cerebral spinal fluid findings with Guillain-Barre?
Albuminocytologic dissociation
Most common organism causing Guillain-Barre?
Campylobacter jejuni
Ascending symmetrical paralysis/weakness with absent or decreased deep tendon reflexes?
Guillain-Barre Syndrome
Treatment for chorea + psychosis?
Haloperidol olanzapine or risperidone
Treatment for Huntington’s chorea?
Tetrabenazine
Mode of inheritance for Huntington’s?
Autosomal dominant
Inherited neurodegenerative disorder characterized by chorea?
Huntington’s
Rapid involuntary irregular jerking motion of the hands face and feet?
Chorea
What disorder has bradykinesia pill rolling tremor masked facies and cogwheel rigidity?
Parkinson’s
Preferred initial treatment for Parkinson’s after age 65?
Levodopa + carbidopa
Causes of intention tremors?
Multiple sclerosis - Brain trauma - Cerebellar disease
Tremor that increases in severity as it reaches its target?
Intention tremor
Treatment for essential tremors?
Propanolol and primidone
Tremor with movement but no tremor at rest?
Essential tremor
Tremor associated with caffeine intake anxiety and lithium therapy?
Physiologic tremor
Preferred first line treatment for Parkinson’s prior to age 65?
Dopamine agonists (bromocriptine - pramipexole - ropinirole)
What disorder has a resting tremor which goes away with movement?
Parkinson’s
When can an athlete return to play after one concussion?
After 1 week with no symptoms
When can an athlete return to play if they have suffered 2 or more concussions in one year?
The following season
Headaches irritability loss of memory or concentration after a concussion?
Post Concussive Syndrome
Concussions are characterized by what Glasgow Coma Score 30 min after injury?
13-15
Mild traumatic brain injury due to contact or acceleration/deceleration injury?
Concussion
Medical treatment for complex seizures?
Phenytoin
Medical treatment for partial seizures?
Carbamazepine or lamotrigine
Pathophysiology of vasovagal (neurocardiac syncope)?
Bradycardia - Vasodilation
Medical treatment for status epilepticus?
IV lorazepam may follow with IV phenytoin
Single nonstop seizure lasting longer than 5 minutes or frequent seizures without a return to baseline?
Status Epilepticus
Seizure in which body is stiff and rigid followed by limb jerking then a post ictal phase?
Tonic-Clonic Seizures
Medical treatment for absence seizures?
Ethosuximide or valproic acid
Seizure common in children in which patient is conscious but not aware (staring)?
Seizure common in children in which patient is conscious but not aware (staring)?
Seizure limited to part of one hemisphere with impaired consciousness?
Complex partial seizure
Seizure limited to part of one hemisphere with consciousness fully maintained?
Simple partial seizure
Acute medical treatment for increased intracranial pressure (ICP)?
Head elevation - Hyperventilation - Osmotic diuresis (mannitol)
Appearance of a subdural hematoma on a CT scan?
Crescent shaped
Vessels involved in a subdural hematoma?
Bridging veins
Most common cause of subdural hematoma?
Head trauma
Appearance of an epidural hematoma on a CT scan?
Lens-shaped
Most common artery affected in an epidural hematoma?
Middle meningeal artery
Transient loss of consciousness after a lucid interval most often due to skull fracture?
Epidural Hematoma
Which brain tumor may present with endocrine signs and symptoms?
Pituitary tumor (may also occur with paraneoplastic syndrome e.g. SC lung CA)
Which brain tumor may present with cranial nerve palsy?
Brain stem tumor (may also occur with cerebral aneurysm and diabetic ischemic neuropathy)
Which brain tumor may present with visual hallucinations?
Occipital lobe tumor (may also occur with migraine and EtOH withdrawal)
Which brain tumor may present with seizures or sensory loss?
Parietal lobe tumor
Which brain tumor may present with lip smacking olfactory or gustatory hallucinations?
Temporal lobe tumor
Which brain tumor may present with personality or intellectual change?
Frontal lobe tumor
Most common primary tumors that spread to the brain?
Breast, lung, GI (colorectal) and kidney
Disorder in which AV malformations in the brain are common?
Hereditary hemorrhagic telangiectasia (AKA: Osler-Weber Rendu Syndrome)
List the causes of hemorrhagic stroke.
Uncontrolled HTN - SAH - Tumors - AV malformation - Anticoagulants - Thrombolytics
Treatment for subarachnoid hemorrhage (SAH)?
Observation - Clip/coil - Seizure prophylaxis (anticonvulsants)
Diagnostic test for subarachnoid hemorrhage (SAH)?
Non-contrast CT of head
Worst headache ever followed by nausea vomiting and impaired consciousness?
Subarachnoid Hemorrhage
Treatment for cerebral aneurysm?
Treatment for cerebral aneurysm?
Diagnostic test for cerebral aneurysms?
Magnetic resonance angiography (MRA) or CT angiography (CTA)
Diseases associated with cerebral aneurysms?
Ehlers-Danlos - Polycystic kidney disease - Coarctation of the aorta
Loss of cerebellar function such as slurred speech vertigo ataxia and/or nystagmus?
Posterior stroke
Contralateral paralysis motor function but still can wrinkle forehead?
Anterior stroke
Reduced blood flow to the brain resulting in tissue damage?
Ischemic Stroke
Treatment for carotid stenosis of 70-99%?
Cortaid endarterectomy
Treatment for TIA in a patient with CAD who is in sinus rhythm?
Clopidogrel
Initial treatment of TIA in a patient without CAD who is in sinus rhythm?
Aspirin (aspirin/dipyridamole better if available)
Brief episode of focal neurologic symptoms such as hemiparesis loss of strength or sensation?
TIA
Initial treatment for Bell’s Palsy?
Corticosteroids
Facial paralysis occurring on the ipsilateral side as herpes zoster?
Ramsay Hunt Syndrome
Unilateral facial paralysis most often caused by Herpes simplex virus?
Bell’s Palsy
Hereditary peripheral neuropathy which affects both motor and sensory?
Charcot-Marie Tooth
Acute treatment for Guillain-Barre Syndrome?
Plasma exchange - IV immune globulin
Type of polyneuropathy that is predominantly motor?
Myelinating
Type of neuropathy that is symmetric and initially sensory?
Axonal
Treatment for daily RLS (restless leg syndrome)?
Dopamine agonists (e.g. ropinirole) - If iron deficient: Iron replacement
Conditions associated with restless leg syndrome (RLS)?
Parkinson’s - Iron deficiency anemia - Diabetes - Multiple Sclerosis - Pregnancy
Spontaneous leg movements/paresthesias present at rest and relieved with movement?
Restless Leg Syndrome
Medical treatment for peripheral neuropathy? (3)
Gabapentin pregabalin or amitriptyline
Stocking glove distribution of chronic polyneuropathy?
Diabetic neuropathy and renal failure related neuropathy due to chronic uremia
Initial diagnostic test for peripheral neuropathy?
Electromyography (Nerve conduction study) (aka EMG and NCS)
Symmetric distal sensory loss burning or weakness?
Peripheral Neuropathy
Treatment for Complex Regional pain syndrome?
Anti convulsants (e.g. gabapentin) - Tricyclic antidepressants (e.g. Amitriptyline - Agents to increase bone mineral density (e.g. alendronate)
Unilateral burning pain in a cyanotic cool extremity may be associated with urinary urgency?
Complex Regional Pain Syndrome (AKA: Reflex Sympathetic Dystrophy)
Preferred prophylaxis for cluster headache?
Verapamil
Acute treatment for cluster headaches?
Subcutaneous or intranasal sumatriptan and inhaled 100% oxygen
Unilateral Ptosis Miosis and Anhydrosis?
Horner Syndrome
Are males or females more likely to suffer from cluster headaches?
Males
Headache with unilateral periorbital pain with rhinorrhea and conjunctival injection?
Cluster headaches
Migraine prophylaxis?
Beta blockers unless > 60 y.o. asthmatic or smoker (commonly propranolol) - Verapamil - Tricyclic antidepressants
Acute treatment for Migraines?
NSAIDs or “Triptans” (e.g. sumatriptan)
Most common type of migraine aura?
Visual: Bright spots
Unilateral throbbing headache with or without an aura?
Migraine
1st line Treatment for Tension headache?
Non- Aspirin NSAIDs
Episodic bilateral headache with pericranial muscle tenderness and normal neuro exam.
Tension headache
A previously healthy elderly patient with no past medical history presents with acute onset altered mental status to the emergency room. What do you suspect?
Delirium - Consider underlying causes such as: Sepsis (UTI common)
What class of medications is often used to treat Alzheimer’s patients?
Cholinesterase inhibitors
What is the difference between delirium and dementia?
Delirium is an acute syndrome caused by a medical condition - Dementia is a long-term impaired memory disease process such as Alzheimer’s
What finding on autopsy confirms the diagnosis of Alzheimer’s?
Beta amyloid plaques and neurofibrillary tangles
What is the most common cause of dementia in an adult after the age of 60?
Alzheimer’s
A 94 year old male, hospitalized for a UTI, becomes confused and is seeing things in his room every evening. What type of delirium do you suspect?
Sun downing
What is the GCS for a patient who only responds to your verbal commands, is confused and localizes to pain?
GCS = 12 Responsive to verbal = 3 - Confused = 4 - Localizes pain = 5
What is the GCS for a patient who does not open his eyes, does not respond to verbal commands, and has no motor response?
GCS = 3 Does not open eyes = 1 - Does not respond to verbal = 1 - No motor response= 1
What is the Glasgow Coma Score (GCS) for a patient who has spontaneous eye-opening, is oriented and obeys commands?
GCS = 15 Spontaneous eye-opening = 4 - Oriented = 5 - Obeys commands= 6
What is the classic triad of meningitis?
Nuchal rigidity - Headache - Fever (Note: nuchal rigidity and headache without fever is suggestive of subarachnoid hemorrhage)
Negri bodies are pathognomonic for what disease process?
Rabies
Which organisms most commonly cause bacterial meningitis in neonates?
Group B Streptococcus and E. Coli
A child with the flu is given Tylenol for his fever and Pepto-Bismol for his upset stomach. He is noted by the parents to become confused and lethargic. What do you suspect?
Reyes syndrome (Pepto-Bismol has salicylates)
What is the difference between encephalitis and meningitis?
Impaired mental status in encephalitis
What are the two most common causes of community acquired meningitis?
Streptococcus pneumoniae - Neisseria meningitidis
What is the recommended treatment for a patient with multiple sclerosis having a severe attack?
Plasma exchange
A patient was found to have oligoclonal bands on lumbar puncture. What do you suspect?
Multiple sclerosis
A young woman with history of optic neuritis presents with left foot weakness and difficult walking. What is your suspected diagnosis?
Multiple sclerosis
What type of progression occurs in patients with cerebral palsy?
Generally none, however, some patients can later develop involuntary movements
What procedure can help with myasthenia gravis in patients under the age of 60?
Thymectomy
What tests are used to diagnose myasthenia gravis?
Edrophonium or Tensilon test and antibodies to acetylcholine receptor and tyrosine kinase
A young woman presents to the office with bilateral eye ptosis and difficulty keeping her head erect. What do you suspect?
Myasthenia gravis
What is the treatment of choice for Guillain-Barre?
Plasma exchange, intravenous immunoglobulin, and supportive care in the ICU for severe cases
A 55 year old male begins to get weakness in all four of his limbs. He has no past medical history and recently had a flu shot. What do you suspect?
Guillain Barre
At what age is Huntington’s disease most commonly diagnosed?
Age 40 to 50 years old - The defining symptom is chorea
What childhood disease process may be diagnosed with the onset of chorea?
Rheumatic fever
What adult disease process is most commonly diagnosed with the onset of chorea?
Huntington’s Disease
What disease processes have an intention tremor?
Multiple sclerosis, cerebellar disease and strokes
What is an intention tremor?
There is no tremor at rest, however with movement the tremor starts and increases in severity as a hand moves closer to its target
What medication class is used to treat Parkinson’s disease in patients younger than 65 or without advanced disease?
Dopamine agonist, such as bromocriptine
What disease condition has a resting tremor that goes away with movement?
Parkinson’s
What is a resting tremor?
A tremor that is seen at rest but goes away with movement
What is the most common cause of tremor in a healthy young adult?
Caffeine is the most common cause of physiologic action tremors
What is the Glasgow Coma Score (GCS) range found in patients with concussions?
13 to 15 GCS Ranges from 3 (worst) to 15 (normal)
A football player is post-concussion and is having frequent headaches, a fuzzy feeling and difficult concentrating. What is the next step?
MRI of the brain (CT if suspect acute bleed)
How long after a second concussion in the same season should a player have to wait before resuming sports?
They are out for the rest of the season
How long after the first concussion should a player be made to wait?
One week without any symptoms
Define status epilepticus
A single nonstop seizure lasting longer than 5 to 10 minutes or frequent seizures without a return to baseline
What is the main treatment for patients with neurogenic syncope?
Patient awareness and education
What is the Bezold-Jarisch reflex?
Transient loss of consciousness due to a reflex response of vasodilation and/or bradycardia
What medication used to treat epilepsy requires regular blood draws to monitor therapeutic levels?
Phenytoin
What is the acute treatment for an active grand mal seizure?
Benzodiazepines (lorazepam)
What is the treatment choice for simple partial and complex partial seizures?
Carbamazepine
What is the difference between simple partial and complex partial seizures?
Impaired consciousness in complex partial but not in simple partial
What is the recommended treatment for a subdural bleed that is causing symptoms?
Burr holes or craniotomy
A man is hit in the head and knocked unconscious. He gets up after a minute and feels fine, in 20 minutes he is drowsy with headache. What do you suspect?
Epidural hematoma
A man hits his head but he appears unhurt. In the two weeks since, he has had persistent headaches and lightheadedness. What do you suspect?
Subdural hematoma
What artery is most commonly involved in epidural bleed?
Middle meningeal artery
CT of the brain demonstrates blood in crescent shaped appearance. What do you suspect?
Subdural hematoma
CT of the brain demonstrates blood in a biconvex lens shaped appearance. What do you suspect?
Epidural
Which modality is better for diagnosis of a brain tumor? CT - MRI or nuclear medicine test
MRI
What do an aneurysm, AVM and brain tumor all have in common?
They can all lead to hemorrhagic stroke and blood in the cerebral spinal fluid
A patient in ER has the “worst headache ever”. CT of the brain is negative but you’re concerned about a subarachnoid hemorrhage. What is the next step?
Lumbar puncture
What is the treatment for a cerebral aneurysm?
Intracranial coiling or clipping
What syndrome is often associated with arteriovenous malformations in the brain
Osler-Weber-Rendu syndrome
What are the common signs seen in a patient with a subarachnoid hemorrhage post rupture?
Nuchal rigidity and meningeal signs
A patient with polycystic kidney disease has sudden onset of the “worst headache ever”. What is the suspected cause?
Ruptured cerebral aneurysm
A patient status post TIA has a carotid ultrasound which shows a lesion of 79% in the left internal carotid. What is the recommended therapy?
Carotid endarterectomy
A patient that had a TIA and has a history of coronary disease should be placed on what antiplatelet therapy?
Clopidogrel
What test should be ordered to determine the source of a TIA in a patient with an irregular heartbeat?
Echocardiogram will determine the source, EKG will only demonstrate atrial fibrillation
What is the mainstay of treatment for bell’s palsy?
Steroids
Define Ramsay Hunt syndrome.
Herpes zoster plus bells palsy
A 23 year old female presents with facial droop, ptosis and a change in her taste sensation. She has no other focal findings. What is your suspected diagnosis?
Bell’s palsy
What medication is used to treat restless leg syndrome?
Treatment is like Parkinson’s using dopamine agonists like pramipexole
A trial of what medication should be given to all patients with restless leg syndrome?
Trial oral iron therapy
An obese patient with peripheral neuropathy may benefit from what medication to help with the neuropathy and weight loss?
Topiramate
A woman complains of aching pain in her legs that is deep inside. It is worse at night when she lays still and feels better when she moves her legs around. What is the likely diagnosis?
Restless leg syndrome
The patient with Charcot-Marie-Tooth has both motor and sensory loss. What type of sensory loss do they have?
Loss of proprioception and loss of vibration
A 12 year old has difficulty running. On exam she has distal muscle weakness, diminished proprioception and vibration as well as hammer toes. What is your suspicion?
Charcot-Marie-Tooth
What type of neuropathy often presents in a stocking glove distribution?
Axonal (sensory) Peripheral neuropathy
A 24 year old male is complaining of increasing symptoms from complex regional pain syndrome and is taking Neurontin. What is the next step in his management?
Steroids
A patient with a history of trauma has severe burning pain, cyanosis and cool skin to his left arm. X-rays show patchy demineralization of the bone. What condition do you suspect?
Complex regional pain syndrome also known as reflex sympathetic dystrophy
What medication used in the treatment of tension headaches often has an abuse potential?
Opiates are commonly used to treat tension headaches
In regards to activity, what is the difference between a migraine and a cluster headache?
Migraine sufferers prefer quiet and laying down while cluster headache patients are restless and tend to pace
What medication is used as prophylaxis for cluster headaches?
Calcium channel blockers such as verapamil
A 44 year old male presents with a severe unilateral headache that seems to be located behind his eye. What type of headache do you suspect?
Cluster headache
What 3 symptoms define Horner syndrome?
Ptosis - Miosis - Anhydrosis
What is the difference between a migraine headache and a TIA regarding symptoms?
TIA will never have aura. Migraine can have aura and, in severe cases, transient loss of motor function
Red wine is a common trigger for what type of headache?
Migraine headache
A 30 year old female presents with a unilateral throbbing headache that was preceded by a colorful aura. What medication is recommended?
Sumatriptan
What medication can be used to prevent tension headaches?
Tricyclic antidepressants such as amitriptyline