Neurology Flashcards

1
Q

What conditions are a contraindication to triptans?

A

Ischaemic heart disease, hypertension and previous stroke or TIA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
1
Q

First line prevention of uncomplicated migraine

A

Beta blocker e.g. atenolol, propanolol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Sensation of being hit in the back of head, smoking history, EDS

A

Ruptured berry aneurysm

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Periorbital headache with ptosis, lacrimation, conjunctival inflammation

A

Cluster headache

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

History of TIA and AF with stepwise decline in memory

A

Vascular dementia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

First line management of mild to moderate dementia

A

Donepezil, rivastigmine or galantamine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Management of moderate to severe dementia

A

Memantine (NMDA antagonist)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Why are people with Down syndrome more likely to get Alzheimer’s?

A

Amyloid precursor protein is found on chromosome 21

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Drug to reduce severity of attacks in MS

A

3 day course oral methylprednisolone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Drug to reduce relapse rate in MS

A

Beta-interferon

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Pt is unable to extend knee due to muscle spasm - should botox be injected into extensor or flexor muscles?

A

Flexors. e.g. biceps femoris if unable to extend knee

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What would you see on CSF panel in MS patient?

A

<1 white cell, <1 red cell, CSF glucose:serum glucose=0.6, protein 0.5 (normal 0.2-0.45g/L), distinct bands of IgG on Western Blot

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Pathological hallmark of MS on MRI

A

Plaques of gadolinium-enhancing T2 hyperintensity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What type of stroke is caused by small vessel infarction?

A

Lacunar stroke (no cortical signs e.g. hemianopia, speech problems)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

First line investigation for suspected subarachnoid haemorrhage

A

CT non-contrast (detects 90% within48h onset)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

WHich nerves are affected first in PNS pathology?

A

Long nerves e.g. legs before arms

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Anticonvulsant causing elevated liver enzymes and hepatic dysfunction

A

Sodium valproate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

How does phenytoin work?

A

By blocking voltage-gated sodium channels to prevent further action potentials

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Pt’s plasma phenytoin level is 7mg (ref 10-20mg) after initial management of seizure with phenytoin, how can a further seizure be prevented?

A

Increase dose of phenytoin
(current levels are below therapeutic window)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Side effects of sodium valproate

A

Think VALPROATE
- Vomiting
- Appetite (increased, weight gain)
- Liver failure
- Pancreatitis
- Reversible hair loss
- Oedema
- Ataxia
- Teratogencity/tremor/thrombocytopenia
- Encephalopathy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

What is Jacksonian march?

A

Leg starts twitching, and movement moves up her right trunk to involve right arm (or left)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

In status epilepticus pts, what should be given after buccal diazepam?

A

IV midazolam

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Jacksonian march and Todd’s palsy are features of what type of seizure?

A

Focal seizure without impairment of consciousness - frontal lobe origin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Features of temporal lobe seizures

A

Aura initially (e.g. feeling sick, a sense of anxiety or smelling unusual smells)

Followed by impaired awareness
- stare blankly
- automatisms (e.g. lip-smacking or fidgeting with their hands)

Post-ictal phase
- slightly confused
- unsure of what has happened.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

How to differentiate between temporal lobe and absence seizures?

A

Absence seizures only last a few seconds and do not have a post-ictal phase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

In what type of seizures is carbamazepine most used?

A

Partial/focal

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

First line for focal seizures

A

Lamotrigine or leviteracetam

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

Def of status epilepticus

A

A seizure lasting 5 minutes or more
OR multiple seizures over 5 minutes without returning to a full level of consciosuness between episodes.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
26
Q

Which cranial nerves carry parasympathetic fibres?

A

X
IX
VII
III

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

mTBI features

A

Loss of consciousness
Amnesia
Fencing posture

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
28
Q

What happens to neurons in mTBI?

A

Neurons pulled apart, leak contents into brain
Neurons that don’t die release NTs and ion fluxes
- K otu, Ca in, battery remotes round the wrong way

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
29
Q

What happens in post-cpncussive phase?

A

Diminished blood flow due to metabolic cascade
Results in poor cerebral response to 2nd injury
- brain more vulnerable

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
30
Q

Unilateral supratentorial arterial bleed suggests what type of haematoma

A

Extradural haematoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
31
Q

Vomiting post-head injury suggests…?

A

SKull fracture

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
32
Q

Cushing’s reflex in head injury

A

Increased blood pressure, decreased heart rate, irregular breathing

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
33
Q

Next line management of IIH patient with one eye decr visual acuity, bilateral papilloedema and some haemorrhage on 250mg acetazolamide

A

Refer to surgeons for consideration of optic nerve fenestrations

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
34
Q

What is Ramsay Hunt II syndrome?

A

Reactivation of varicella zoster virus in the geniculate ganglion.
Unilateral acute facial nerve paralysis, erythematous vesicular rash in the ear canal.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
35
Q

Lumbar spinal stenosis pain gets better when patient does what?

A

Bend forward when sitting down

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
36
Q

Peripheral neuropathy is caused by which TB drug?

A

Isoniazid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
37
Q

Presentation of Wernicke’s encephalopathy

A

Tetrad of confusion, ataxia, nystagmus and opthalmoplegia

Hx of alcohol dependency

Manage with thiamine to avoid the development of Korsakoff syndrome

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
38
Q

Which muscle disorder is managed with prednisolone and pyridostigmine?

A

Myasthenia gravis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
39
Q

Management of essential tremor

A

Propranolol!!!! primidone, topiramate, gabapentin, clonazepam.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
40
Q

Management of Ramsay Hunt syndrome

A

Prednisolone and acyclovir

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
41
Q

Which antibody is most commonly positive in myasthenia gravis?

A

Nicotinic acetylcholine receptor (nAChR)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
42
Q

What drug is given in conjunction with levadopa in PD and why?

A

Carbidopa
- reduces the breakdown of levodopa peripherally, leading to a better therapeutic effect.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
43
Q

Name a nausea drug that makes Parksinonism symptoms worse

A

Metoclopramide
- it’s a dopamine antagonist but also has a bit of 5HT3 antagonism

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
44
Q

Right upper and lower limb motor power and sensation both reduced - where is the infarct?

A

MCA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
45
Q

Wernicke’s vs Broca’s apahasia

A

Wernicke = word salad
Broca = broken speech

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
46
Q

What is hereditary spastic paraparesis?

A

Degeneration of corticospinal tracts and sometimes dorsal column
Presents with spasticity, hyperreflexia and gait disturbance

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
47
Q

Scissor gait suggests?

A

Increased muscle tone in the adductor muscles
e.g. due to herediatry spastic paraparesis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
48
Q

Hemiplegia, homonymous hemianopia, and Wernicke’s dysphasia - where is the infarct?

A

Lateral hemisphere - supplied by MCA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
49
Q

Investigation to diagnose encephalitis

A

CSF viral PCR
- most common cause is HSV

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
50
Q

Proximal muscle weakness which improves on repetition with Hx of small cell lung cancer?

A

Lambert Eaton syndrome

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
51
Q

Excessive alcohol intake assoc with peripheral neuropathy, hyporeflexia and muscle atrophy of lower limbs suggests which deficiency?

A

Thiamine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
52
Q

Xanthochromia in CSF?

A

Subarachnoid haemorrhage
- CT angio

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
53
Q

Management of Bell’s palsy

A

Prednisolone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
54
Q

Features of Lewy body dementia

A

Cognitive impairment and non-threatening visual hallucinations assoc with Parkinsonian triad

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
55
Q

Clin pres of progressive supranuclear palsy

A

Parkinsonian triad of tremor, hypertonia, and bradykinesia
- with a vertical gaze palsy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
56
Q

Common non-motor symptom of parkinson’s

A

Anosmia
Postural hypotension

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
57
Q

Management of on and off motor symptoms in Parkinson’s

A

MAO-B inhibitor - such as rasagiline
COMT inhibitor - entacapone
Dopamine antagonist

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
58
Q

What medication is given alongside levadopa to increase its bioavailability?

A

Carbidopa
- it reduces the breakdown of levodopa peripherally, leading to a better therapeutic effect.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
59
Q

BP contraindication for thrombolysis

A

blood pressure greater than 180/110mmHg

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
60
Q

PMN WCC, raised protein and low glucose suggest which cause of meningitis?

A

Bacterial

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
61
Q

Left homonymous hemianopia with macular sparing would result from infarct in which cerebral artery?

A

Right posterior cerebral
- posterior cerebral artery supplies corresponding occipital cortex which encodes contralateral visual field
- macular sparing because macular vision is encoded bilaterally like the forehead

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
62
Q

When is aspirin given in stroke?

A

Aspirin 300mg 24h after after alteplase treatment for 2 weeks afterwards
- only if CT has ruled out haemorrhagic stroke

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
63
Q

Test to confirm narcolepsy

A

Multiple Sleep latency test

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
64
Q

Management of jerky movements in hands etc known as choreoathetosis

A

Tetrabenazine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
65
Q

Test to monitor for resp failure in GBS pts

A

Regular FVC

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
66
Q

Which drug can be used to reduce the risk of long term neurological symptoms in bacterial meningitis?

A

Dexamethasone IV
- given within 4h of IV antibiotics

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
67
Q

Mechanism of action of dipyridamole

A

Inhibits phosphodiesterase and adenosine deaminase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
68
Q

Dupuytren’s contracture caused by which antiepileptic?

A

Phenytoin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
69
Q

How long after onset can you provide thrombolysis?

A

4.5 h
- thrombolyse first and then aspirin 24h later after CT to confirm no subsequent haemorrhage

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
70
Q

Headache accompanied by vertigo, diplopia, dysarthria and tinnitus, as well as bilateral visual symptoms and bilateral paresthesias.

A

Basilar migraine
- manage ibuprofen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
71
Q

How does anticipation occur in Huntington’s?

A

Spermatogenesis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
72
Q

Acute dystonic reaction is usually caused by what type of drug?

A

Dopamine antagonist e.g. metaclopramide
- forced extension of the neck, rigid opening of the jaw, and sustained upward deviation of the eyes.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
73
Q

LP changes in GBS

A

isolated rise in CSF protein

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
74
Q

Only licensed med in MND?

A

Riluzole

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
75
Q

types of stroke reformat this

A

AICA: lateral pontine syndrome = Marie-Foix. CN7 and 8. ipsilateral (unless stated otherwise):
VAN - H = vertigo, ataxia, anaesthesia (CL body, IL face), nystagmus and Horner’s.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
76
Q

Hx of head injury and CT showing only one ventricle, ?haemorrhage

A

Subdural haemorrhage

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
77
Q

Does extradural or subdural haemorrhage have a faster symptom onset?

A

Extradural

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
78
Q

Ipisilateral occulomotor palsy and contralateral limb weakness suggests infarct affecting which artery

A

Posterior cerebral artery

79
Q

Lesion of which cranial nerve would present with nystagmus?

A

CNVIII
- balance etc

80
Q

Sudden vertigo, deafness, vomiting, ipsilateral facial paralysis

A

Anterior inferior cerebellar infarct

81
Q

Management of hypoglycaemia in pt with IV access but no swallow ability

A

100ml 20% glucose

82
Q

What does hyperattenuation on CT mean in stroke?

A

Haemorrhagic stroke

83
Q

Is ischaemic heart disease contraindicative to thrombolysis or thrombectomy?

A

NOOOOOO

84
Q

Management of essential thrombocytosis

A

Hydroxycarbamide

85
Q

To which artery is thrombectomy most beneficial?

A

Proximal middle cerebral artery

86
Q

Which lobe is affected if pt is right handed?

A

Left (always contralateral to handedness)

87
Q

UMN signs post-stroke

A

Clonus, hypertonia, muscle weakness

88
Q

LMN signs post-stroke

A

Hypotonia, muscular atrophy, hyporeflexia, fasciculations

89
Q

Long term stroke prophylaxis

A

Clopidogrel 75mg OD
Atorvastatin 80mg OD

90
Q

Clumsy hand dysarthria is a type of…

A

Lacunar infarct syndrome

91
Q

INR level contradicating thrombolysis?

A

INR >1.7

92
Q

Type of stroke causing locked in syndrome

A

Basilar artery stroke
- only get vertical eye movements and blinking

93
Q

How to investigate the cause of a young person’s stroke post-DVT with no APS Hx?

A

Bubble echocardiogram
- ?patent foramen ovale

94
Q

Specific epileptic symptoms and where they originate from

A

Frontal Lobe: Jacksonian March
Parietal Lobe Paraesthesia
Occipital Lobe: Visual phenomena
Temporal Lobe: HEAD*

95
Q

Triad of myoclonic jerks, absence seizures and generalised TC seizures

A

Juvenile myoclonic epilepsy

96
Q

Which hormone is raised post-ictally and can help differentiate between NEAD and true epilepsy?

A

Prolactin

97
Q

Bilaterak reduced power more prominent in RHD with normal tone and reflexes, some prox thigh fasciculations and pos anti GM1 Abs

A

Multifocal motor neuropathy

98
Q

What does pos rombergs test mean?

A

Sensory ataxia (loss of proprioception in distal legs

99
Q

First line for neuropathic pain

A

Gabapentin, pregablin, duloextine, amitryptiline

100
Q

Most common visual defect assoc with optic neuritis

A

Central scotoma

101
Q

SCDC involves which tracts of the spinal cord?

A

Dorsal and lateral
- spinothalamic unaffected so pain and temp sense are maintained

102
Q

Resting tremor and bradykinesia and rigidity

A

triad of Parkinson’s

103
Q

Temporal lobe lesions on MRI in a young boy with HSV

A

Viral encephalitis

104
Q

WHich facial muscle is spared in stroke?

A

Anterior part of occipitofrontalis muscle

105
Q

Loss of taste to ant 2/3 of tongue, ear pain and deafness?

A

Bell’s palsy

106
Q

Subdural haemorrhage ocurs from bleeding from whcih vessels

A

Bridging vessels between dural venous sinuses and cortex

107
Q

Stroke with no motor symptoms is likely….

A

Post cerebral artery infarct

108
Q

Wernickes area is supplied by….

A

Inf division of MCA on dominant side

109
Q

Stroke with only symptom being contralateral numbness?

A

LACS

110
Q

Spindle cells and psammoma bodies on tumour histology

A

Meningioma

111
Q

Post communicating artery aneurysm would likely present with which cranial nerve palsy?

A

CNIII
- diplopia and nystagmus

112
Q

Contralateral hemiparesis and sensory lss with lower etxremity more affected

A

Anterior cerebral artery infarct

113
Q

First line investigation of Horner’s syndrome

A

CXR for pancoast tumour
- less likely post-thyroidectomy or surgical trauma

114
Q

Where is the lesion if pt presents with RAPD?

A

Optic nerve
- think optic neuritis

115
Q

Aphasia, headache, psychiatric symptoms, fever

A

HSV encephalitis
- aphasia indicates temporal lobe involvement
- LP would show lymphocytosis and incr protein

116
Q

Tremor worse with alcohol and grabbing things

A

Essential tremor
-auto dominant usually

117
Q

Transient painful visual loss in one eye, horizontal diplopia, electric pain after a bath

A

MS (MRI brain and spine)
1. Optic neuritis
2. Internuclear ophthalmoplegia
3. Lermitte’s

118
Q

L5 radiculopathy presents with

A

Weakness of foot dorsiflexors, inverters and everters
NP pain in lumbar, posterior thigh, antlat leg, foot and big toe
Sensory loss at first webbed space

119
Q

Bacterial infection on LP

A

Pos culture
Incr white cells (PMN leukocytes, immune response)
Incr protein (bacterial replication)
Decr glucose (bacteria eats it)

120
Q

Meningitis prophylaxis

A

People in household should get 500mg one off oral ciprofloxacin
- don’t think this is on Tayside formulary
- under 12s get 250mg

121
Q

Wallenberg’s syndrome

A

Infarct of lateral medulla
- post inf cerebellar artery
- ipisilateral horner syndrome
- contralateral pain and temp loss
- ataxia/nystagmus
- CN 9,10,11,12 palsy

122
Q

Groggy after unwitnessed collapse

A

SPECIFIC sign of post-ictal phase of epileptic seizure

123
Q

Ipsilateral CNIII palsy and contralateral weakness

A

Weber’s syndrome
- “pt presents with left down and out eye and right sided weakness of limbs”

124
Q

Management of Bell’s palsy

A

Oral prednisolone
+ otoscopy to check for Ramsay Hunt (usually ext ear vesicular rash but can also appear on TM)

125
Q

Common peroneal vs tibial nerve function

A

TIPPED
- Tibial Inverts and Plantarflexes
- Peroneal Everts and Dorsiflexes (palsy = footdrop)

126
Q

Clinical difference between mononeuritis multiplex and MS

A

Mononeuritis only has LMN signs
- MS has both but UMN signs predominate on examination

127
Q

Which symptoms do not present in TIA?

A

Headache (suggests migrane etc)
Shaking/motor signs before attack (suggests seizure)

128
Q

Most common cause medical CNIII palsy

A

Diabetes

129
Q

Hypersensitive carotid sinus reflex is caused by…

A

Hypoglossal nerve
- when pressure applied to neck HR decr

130
Q

Why are Ca channel blockers used in haemorrhage?

A

Prevention of vasospasm-induced cerebral ischaemia to allow for optimal perfusion

131
Q

Mx menière’s disease

A

Diuretics and low salt diet

132
Q

How to diff between ischaemic and haemorrhagic stroke on CT?

A

Ischaemic stroke: HYPO-dense area on CT
Haemorrhagic stroke: HYPER-dense area on CT

133
Q

Anti epileptic causing stones and WL

A

Topiramate
- topaz crystals in the kids

134
Q

Migraine prophylaxis

A

Topiramate
- teratogenic
Amitriptyline
- if u don’t know contraception status

135
Q

‘Loss of grey-white matter differentiation’ on CT in a pt woken up confused with slurred speech

A

Cytotoxic oedema 2o to ischaemic stroke

136
Q

Gm pos rod cause of meningitis in pregnancy

A

Listeria
- from food e.g. soft cheese
- can cause chorioamnionitis and pre term labour

137
Q

ARDS + pyrexial, tachycardic and has laboured breathing. She also appears floppy and lethargic, but there are no dysmorphic features, mother ate loads of cheese in pregnancy

A

Listeria
- meconium stained liquor is also a RF

138
Q

Crescent-shaped homogeneously hyper-dense extra-axial collection adjacent to the left fronto-parietal convexity

A

Subdural haematoma
- recurrent falls and confusion with risk factors including alcohol use, age, recent trauma, anticoag use)

139
Q

Parkinsonism + defective upward gaze + personality change

A

Pro-gaze-ssive supranuclear balls-y
- prog supranuclear palsy

140
Q

Brown Sequard T10 on right side findings

A

Increased tone and hypereflexia, extensor plantar response and reduced joint position sense in the right leg, loss of pain and temperature sensation from the left leg up to the level of the umbilicus. Normal examination of the arms

141
Q

How many doses of benzo should you try in status epilepticus before trying something else?

A

2 doses max
- move on to phenytoin or valproate
- after 20 mins there is serious risk and gen anaesthesia should be considered

142
Q

Establishes status epilepticus?

A

> 20 mins seizure activity
10 mins with no response to benzos

143
Q

Burr hole vs craniotomy in acute subdural haemorrhage

A

Craniotomy
- burr hole for chronic

144
Q

Why is high BP (>190 systolic) a contraindication to thrombolysis?

A

High BP + Thrombolysis = Brain haemorrhage

145
Q

Barthel index

A

To assess functional independence in post-stroke pts

146
Q

Type of sweaty problems in Horner’s syndrome

A

Anhidrosis

147
Q

How can you relieve acute dystonia?

A

Anticholinergic
- procyclidine or biperiden

148
Q

What is Todd’s palsy?

A

Essentially paralysis/exhaustion after a frontal lobe focal seizure

149
Q

What does split hand mean in MND?

A

The radial aspect of the hand is far more affected than the ulnar aspect

150
Q

Ipsilateral: facial paralysis/pain and temperature loss/deafness
Contralateral: limb/torso pain and temperature loss
Ataxia, nystagmus

A

AICA
AICAnt hear you

151
Q

Which cranial nerves are affected y the cerebellar strokes?

A

AICA = CN5, 6, 7, 8
PICA = CN9, 10, 11, 12

152
Q

What type of bitemp hemianopia would present first?

A

Lower
- due to craniopharyngeoma

153
Q

Is Bell’s palsy upper or lower MN problem?

A

Lower - two Ls in Bell’s

154
Q

Gradual onset severe headache associated with nausea and three episodes of vomiting

A
155
Q

Sensory loss of posterolateral aspect of leg and lateral aspect of foot, weakness in plantar flexion of foot, reduced ankle reflex, positive sciatic nerve stretch test

A

S1 root lesion

156
Q

First line management of trigeminal neuralgia

A

Carbamazepine

157
Q

First line management of an acute dystonic reaction

A

Procyclicdine

158
Q

First line treatment of Wernicke’s encephalopathy

A

IV pabrinex

159
Q

India ink stain meningitis

A

Cryptococcus neoformans

160
Q

First line prophylaxis for migrain

A

Propranolol
- topiramate if contraindicated e.g. in asthma

161
Q

WHen can LP in SAH be done?

A

12h after onset
- this is when blood will break down and xanthochromia will be seen

162
Q

Acetylcholine receptor antibodies

A

Myasthenia gravis

163
Q

Anti voltage gated calcium channel antibodies

A

LEMS

164
Q

PICA stroke/lat medullary/Wallenberg

A

DANVAH
Dysphagia, ipsilateral Ataxia, ipsilateral Nystagmus, Vertigo, Anaesthesia, ipislateral Horner’s

165
Q

Where is the lesion in internuclear ophthalmoplegia?

A

Lesion on the contralateral Medial Longitudinal Fasciculus (MLF)

166
Q

Frontal balding and unable to let go when shaking hand, prog hand weakness

A

Myotonic dystrophy
- trinucleotide repeat

167
Q

What eye condition may indicate TIA?

A

Amaurosis fugax
- essentially is an eye TIA
- vision goes without pain and them comes back
- cotton wool spots and hard exudates

168
Q

Type 1 vs 2 CMT

A

Inherited polyneuropathy with champagne bottle legs

Type 1 = demyelinating
Type 2 = axonal

169
Q

Familial ALS mutation

A

SOD1

170
Q

Risk factors for thiamine defic (and 2o wernicke’s encephalopathy)

A

Alcohol abuse, malnutrition, bariatric surgery, and hyperemesis gravidarum

171
Q

Most common cause of intracranial haemorrhage, can be exacerbated by straining or valsalva maneouevres

A

Hypertension

172
Q

Huntington’s shows atrophy of….

A

Caudate nucleus and putamen

173
Q

How does parietal lobe damage present?

A

contralateral visual field, astereognosis, constructional apraxia (non-dominant), dressing apraxia (non-dominant) and ideomotor apraxia (dominant). Right hemisphere (i.e. non-dominant) parietal lesions are particularly prone to producing visual neglect.

174
Q

Noncontrast CT hyperdensity

A

Thombosis

175
Q

Severe, throbbing headache occurring all across her head, nausea and vomiting, non contrast CT shows hyperdensity in sagittal sinus

A

Intracranial venous thrombosis

176
Q

Delta sign on CT in context of stroke

A

Filling defect in sagittal sinus

177
Q

Management of severe hypoglycaemia

A

20% glucose solution IV

178
Q

Hypo or hyperreflexia in SCDC?

A

Hyperreflexia

179
Q

Alternative to clopidogrel in TIA prevention

A

Change to dual therapy with aspirin and modified-release dipyridamole

180
Q

Stroke presenting with contralateral homonymous hemianopia with macular sparing and visual agnosia

A

Posterior cerebral artery

181
Q

Sweaty and anxious pt with history of bilateral lower limb paraplegia 2o to transection of spinal cord, Cushing’s signs

A

Faecal impaction / urinary retention are the most common triggers of autonomic dysreflexia

182
Q

Elec imbalance following SAH

A

Hyponatraemia

183
Q

Management of myasthenic crisis

A

intravenous immunoglobulin, plasmapheresis

184
Q

Pit adenoma vs craniopharyngioma

A

Pit adenoma
- pushes up from below = superior quantrantopia
Craniopharyngioma
- pushes down from above = inferior quantropia

185
Q

How to remember where uvula/tongue deviates to in cranial nerve palsy?

A

CNX = uvulA = Away
CNXII = Tongue = Towards

186
Q

Midbrain stroke characterised by the an ipsilateral CN III palsy and contralateral hemiparesis

A

Weber’s syndrome

187
Q

Bleeding in subdural haemorrhage is due to

A

bridging veins between cortex and venous sinuses

188
Q

As well as MRI, what other inv should all TIA patients get?

A

Carotid artery doppler

189
Q

How does hyperventilation work to reduce raised ICP?

A

Hyperventilation -> reduce CO2 -> vasoconstriction of the cerebral arteries -> reduced ICP

190
Q

Derm reaction caused by carbamazepine

A

Stephen Johnson
- watch for new med changes and new rash covering mouth and significant area of skin

191
Q

Negative CSF findings with lower limb weakness, progressive

A

GBS
- neg CSF is essential for diagnosis

192
Q

Loss of pain and temp sensation but intact DCML senses in Chiari malformation

A

Syringomyelia
- dilatation of a CSF space within the spinal cord

193
Q

First seizure but normal imaging and EEG - driving?

A

Stop driving for 6 months

194
Q

Which primary cancers most commonly met to the brain?

A

Left Brained Metastases Can Kill
Lung >Breast > Melanoma > Colorectal > Kidney

195
Q

Improvement in muscle power with exercise

A

LEMS

196
Q

Symmetrical tremor in PD

A

Drug induced

197
Q

Management MG vs MG crisis

A

MG - pyridostigmine
MG Crisis - Ig

198
Q
A