Neurology Flashcards
What conditions are a contraindication to triptans?
Ischaemic heart disease, hypertension and previous stroke or TIA
First line prevention of uncomplicated migraine
Beta blocker e.g. atenolol, propanolol
Sensation of being hit in the back of head, smoking history, EDS
Ruptured berry aneurysm
Periorbital headache with ptosis, lacrimation, conjunctival inflammation
Cluster headache
History of TIA and AF with stepwise decline in memory
Vascular dementia
First line management of mild to moderate dementia
Donepezil, rivastigmine or galantamine
Management of moderate to severe dementia
Memantine (NMDA antagonist)
Why are people with Down syndrome more likely to get Alzheimer’s?
Amyloid precursor protein is found on chromosome 21
Drug to reduce severity of attacks in MS
3 day course oral methylprednisolone
Drug to reduce relapse rate in MS
Beta-interferon
Pt is unable to extend knee due to muscle spasm - should botox be injected into extensor or flexor muscles?
Flexors. e.g. biceps femoris if unable to extend knee
What would you see on CSF panel in MS patient?
<1 white cell, <1 red cell, CSF glucose:serum glucose=0.6, protein 0.5 (normal 0.2-0.45g/L), distinct bands of IgG on Western Blot
Pathological hallmark of MS on MRI
Plaques of gadolinium-enhancing T2 hyperintensity
What type of stroke is caused by small vessel infarction?
Lacunar stroke (no cortical signs e.g. hemianopia, speech problems)
First line investigation for suspected subarachnoid haemorrhage
CT non-contrast (detects 90% within48h onset)
WHich nerves are affected first in PNS pathology?
Long nerves e.g. legs before arms
Anticonvulsant causing elevated liver enzymes and hepatic dysfunction
Sodium valproate
How does phenytoin work?
By blocking voltage-gated sodium channels to prevent further action potentials
Pt’s plasma phenytoin level is 7mg (ref 10-20mg) after initial management of seizure with phenytoin, how can a further seizure be prevented?
Increase dose of phenytoin
(current levels are below therapeutic window)
Side effects of sodium valproate
Think VALPROATE
- Vomiting
- Appetite (increased, weight gain)
- Liver failure
- Pancreatitis
- Reversible hair loss
- Oedema
- Ataxia
- Teratogencity/tremor/thrombocytopenia
- Encephalopathy
What is Jacksonian march?
Leg starts twitching, and movement moves up her right trunk to involve right arm (or left)
In status epilepticus pts, what should be given after buccal diazepam?
IV midazolam
Jacksonian march and Todd’s palsy are features of what type of seizure?
Focal seizure without impairment of consciousness - frontal lobe origin
Features of temporal lobe seizures
Aura initially (e.g. feeling sick, a sense of anxiety or smelling unusual smells)
Followed by impaired awareness
- stare blankly
- automatisms (e.g. lip-smacking or fidgeting with their hands)
Post-ictal phase
- slightly confused
- unsure of what has happened.
How to differentiate between temporal lobe and absence seizures?
Absence seizures only last a few seconds and do not have a post-ictal phase
In what type of seizures is carbamazepine most used?
Partial/focal
First line for focal seizures
Lamotrigine or leviteracetam
Def of status epilepticus
A seizure lasting 5 minutes or more
OR multiple seizures over 5 minutes without returning to a full level of consciosuness between episodes.
Which cranial nerves carry parasympathetic fibres?
X
IX
VII
III
mTBI features
Loss of consciousness
Amnesia
Fencing posture
What happens to neurons in mTBI?
Neurons pulled apart, leak contents into brain
Neurons that don’t die release NTs and ion fluxes
- K otu, Ca in, battery remotes round the wrong way
What happens in post-cpncussive phase?
Diminished blood flow due to metabolic cascade
Results in poor cerebral response to 2nd injury
- brain more vulnerable
Unilateral supratentorial arterial bleed suggests what type of haematoma
Extradural haematoma
Vomiting post-head injury suggests…?
SKull fracture
Cushing’s reflex in head injury
Increased blood pressure, decreased heart rate, irregular breathing
Next line management of IIH patient with one eye decr visual acuity, bilateral papilloedema and some haemorrhage on 250mg acetazolamide
Refer to surgeons for consideration of optic nerve fenestrations
What is Ramsay Hunt II syndrome?
Reactivation of varicella zoster virus in the geniculate ganglion.
Unilateral acute facial nerve paralysis, erythematous vesicular rash in the ear canal.
Lumbar spinal stenosis pain gets better when patient does what?
Bend forward when sitting down
Peripheral neuropathy is caused by which TB drug?
Isoniazid
Presentation of Wernicke’s encephalopathy
Tetrad of confusion, ataxia, nystagmus and opthalmoplegia
Hx of alcohol dependency
Manage with thiamine to avoid the development of Korsakoff syndrome
Which muscle disorder is managed with prednisolone and pyridostigmine?
Myasthenia gravis
Management of essential tremor
Propranolol!!!! primidone, topiramate, gabapentin, clonazepam.
Management of Ramsay Hunt syndrome
Prednisolone and acyclovir
Which antibody is most commonly positive in myasthenia gravis?
Nicotinic acetylcholine receptor (nAChR)
What drug is given in conjunction with levadopa in PD and why?
Carbidopa
- reduces the breakdown of levodopa peripherally, leading to a better therapeutic effect.
Name a nausea drug that makes Parksinonism symptoms worse
Metoclopramide
- it’s a dopamine antagonist but also has a bit of 5HT3 antagonism
Right upper and lower limb motor power and sensation both reduced - where is the infarct?
MCA
Wernicke’s vs Broca’s apahasia
Wernicke = word salad
Broca = broken speech
What is hereditary spastic paraparesis?
Degeneration of corticospinal tracts and sometimes dorsal column
Presents with spasticity, hyperreflexia and gait disturbance
Scissor gait suggests?
Increased muscle tone in the adductor muscles
e.g. due to herediatry spastic paraparesis
Hemiplegia, homonymous hemianopia, and Wernicke’s dysphasia - where is the infarct?
Lateral hemisphere - supplied by MCA
Investigation to diagnose encephalitis
CSF viral PCR
- most common cause is HSV
Proximal muscle weakness which improves on repetition with Hx of small cell lung cancer?
Lambert Eaton syndrome
Excessive alcohol intake assoc with peripheral neuropathy, hyporeflexia and muscle atrophy of lower limbs suggests which deficiency?
Thiamine
Xanthochromia in CSF?
Subarachnoid haemorrhage
- CT angio
Management of Bell’s palsy
Prednisolone
Features of Lewy body dementia
Cognitive impairment and non-threatening visual hallucinations assoc with Parkinsonian triad
Clin pres of progressive supranuclear palsy
Parkinsonian triad of tremor, hypertonia, and bradykinesia
- with a vertical gaze palsy
Common non-motor symptom of parkinson’s
Anosmia
Postural hypotension
Management of on and off motor symptoms in Parkinson’s
MAO-B inhibitor - such as rasagiline
COMT inhibitor - entacapone
Dopamine antagonist
What medication is given alongside levadopa to increase its bioavailability?
Carbidopa
- it reduces the breakdown of levodopa peripherally, leading to a better therapeutic effect.
BP contraindication for thrombolysis
blood pressure greater than 180/110mmHg
PMN WCC, raised protein and low glucose suggest which cause of meningitis?
Bacterial
Left homonymous hemianopia with macular sparing would result from infarct in which cerebral artery?
Right posterior cerebral
- posterior cerebral artery supplies corresponding occipital cortex which encodes contralateral visual field
- macular sparing because macular vision is encoded bilaterally like the forehead
When is aspirin given in stroke?
Aspirin 300mg 24h after after alteplase treatment for 2 weeks afterwards
- only if CT has ruled out haemorrhagic stroke
Test to confirm narcolepsy
Multiple Sleep latency test
Management of jerky movements in hands etc known as choreoathetosis
Tetrabenazine
Test to monitor for resp failure in GBS pts
Regular FVC
Which drug can be used to reduce the risk of long term neurological symptoms in bacterial meningitis?
Dexamethasone IV
- given within 4h of IV antibiotics
Mechanism of action of dipyridamole
Inhibits phosphodiesterase and adenosine deaminase
Dupuytren’s contracture caused by which antiepileptic?
Phenytoin
How long after onset can you provide thrombolysis?
4.5 h
- thrombolyse first and then aspirin 24h later after CT to confirm no subsequent haemorrhage
Headache accompanied by vertigo, diplopia, dysarthria and tinnitus, as well as bilateral visual symptoms and bilateral paresthesias.
Basilar migraine
- manage ibuprofen
How does anticipation occur in Huntington’s?
Spermatogenesis
Acute dystonic reaction is usually caused by what type of drug?
Dopamine antagonist e.g. metaclopramide
- forced extension of the neck, rigid opening of the jaw, and sustained upward deviation of the eyes.
LP changes in GBS
isolated rise in CSF protein
Only licensed med in MND?
Riluzole
types of stroke reformat this
AICA: lateral pontine syndrome = Marie-Foix. CN7 and 8. ipsilateral (unless stated otherwise):
VAN - H = vertigo, ataxia, anaesthesia (CL body, IL face), nystagmus and Horner’s.
Hx of head injury and CT showing only one ventricle, ?haemorrhage
Subdural haemorrhage
Does extradural or subdural haemorrhage have a faster symptom onset?
Extradural