Neurology 1 - Demyelination, Facial Pain And Cerebrovascular Flashcards

1
Q

Look at m recap

A
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2
Q

What is a stroke?
What are the 2 types?
What are the stroke common symptoms?

A

A focal neurological deficit which lasts longer than 24 hours resulting from a vascular lesion.

  1. Ischaemic
  2. Haemorrhagic

Face – Asymmetry of the face – Unilateral palsy
Arms – Weakness in the arms
Speech - Slurring of speech - (Dysarthria)
Time – Phone for help

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3
Q

Stroke symptoms?

A

Sudden numbness or weakness in the face, arm, or leg, especially on one side of the body.
Palsy is paralysis.

Sudden severe headache with no known cause. (Haemorrhagic)

Confusion, trouble speaking, or difficulty understanding speech.

Aphasia is an impairment of language, affecting the production or comprehension of speech and the ability to read or write.

Sudden trouble seeing in one or both eyes. (Visual Field Defects)

Ataxia - Sudden trouble walking (gait disturbance), dizziness, loss of balance, or lack of coordination.

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4
Q

Ischaemic stroke?
How do you treat it?

A

Area of the brain deprived of blood

Obstruction blocks the flow to part of the brain

Thrombus (Atheroma, Vegetations – IE) Atheroma / atherosclerotic plaques Severe hypoteinsion

80% of all stroke events

Treatment with thrombolysis in acute phase (Alteplase)

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5
Q

Haemorrhagic stroke?

A

Area of bleeding

Weakened vessel walls rupturing causing bleeding into the brain

Aneurysm

20% of all stroke events

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6
Q

What is a Transient Ischemic Attack ?

A

A focal neurological deficit which lasts less than 24 hours resulting from a vascular lesion. The deficit fully resolves

Temporary in nature

Requires active preventative treatment and investigation

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7
Q

Risk factors of a stroke?

A

Diabetes
Cigarettes
Obesity
Oestrogen OCP
Excess EtOH
Polycythaemia (Raised haemaglobin)
Atheroma (hypercholesterol / lipid aemia)

Hereditable nature
Hypertension

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8
Q

Is left side is damaged what side of body paralysed?

A
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9
Q

Lesions and outcomes of a stroke

A
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10
Q

What is the treatment and risk reduction of a stroke?

A

Nil by mouth = no food, drink or mouth medication (until salt therapy - language and speech assessment)

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11
Q

What can be given to prevent a TIA?

A

Carotid endarterectomy

Tia = warning shot / mini stroke

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12
Q

What is Subarachnoid Haemorrhage ?

A

Uncommon type of stroke caused by bleeding into the brain. - Arterial

Classic “Thunderclap headache” with neck stiffness
Circle of Willis Berry Aneurysm rupture
Sudden LOC – shortly after event

Menginism
High pressure so fast onset
MRI
Often Neuro surgery  clip & Tie bleeder if not stopped spontaneously

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13
Q

What is extradural haematoma?

A

Young patient

Involved in a head strike (either during sport or a result of a motor vehicle accident) may or may not lose consciousness transiently.

Following the injury they regain a normal level of consciousness (lucid interval).

Usually have an ongoing and often severe headache.

Over the next few hours they gradually lose consciousness.

Arterial Middle meningeal artery damage CT/MRI - convex blood mass

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14
Q

What is subdural haematoma?

A

“Below the dura”

Slower onset – venous

Collection between the dura and the brain

Blood collection causes ”mass effect”

Typically after fall (anti- coagulants)

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15
Q

What are the different types of brain haemorrhage?
(4)

A

1) epidural haematoma
2) subdural haematoma
3) subarachnoid haemorrhage
4) inter-cerebral haemorrhage

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16
Q

What is epilepsy?
What are the types of epilepsy?
Does epilepsy always have seizures?

A

A neurological disorder marked by sudden recurrent episodes of sensory disturbance, loss of consciousness, or convulsions, associated with abnormal electrical activity in the brain.

Various types of epilepsy – General, Focal (simple partial)

Not all have seizures

Temporary bursts of electrical activity in the brain that affects how the brain works.

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17
Q

When does epilepsy start?
How long does epilepsy last?
How is epilepsy managed?

A

Can start at any age, but usually in childhood or over 60
Can be secondary to other neurological pathologies – tumors / strokes
Life-long condition
Managed with anti-convulsants

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18
Q

What is a tonic clonic seizure? (Grand mal)

A

Muscle Contractions
Stiff, Jerking muscular movements
Unable to communicate – blank stare / aphasic
Vomiting or loss of bladder/bowels
Cheek and tongue biting
Breathing difficulties
Loss of consciousness
Recovery – Variable but 5 minute duration not unusual
“Feels like I ran a marathon”

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19
Q

What are simple partial seizures?

A

Simple partial (focal) seizures or “auras” can cause:

A simple partial seizure a general strange feeling that’s hard to describe

A feeling that events have happened before (déjà vu)

A sinking feeling in your abdomen – like when on a fairground ride

Unusual smells or tastes / tingling in your arms and legs stiffness or twitching in part of your body, such as an arm or hand
You remain awake and aware while this happens.
Considered as “warnings” or “auras” as they can be a herald of another type of seizure

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20
Q

What are complex partial seizures?

A

During a complex partial seizure, you lose your sense of awareness and make random body movements, such as:

Smacking of lips

Rubbing of hands

Making random noises

Moving arms around

Picking at clothes or fiddling with objects

Chewing or swallowing

Patient won’t be able to respond to anyone during seizure and won’t have any memory of it.

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21
Q

What is Absences (Petit-mal) ?
Absence Seizure

A

An absence seizure, is where you lose awareness of your surroundings for a short time. Mainly affect children, but can happen at any age.
During an absence seizure, a person may:
Stare blankly into space
Look like they’re “daydreaming”
Flutter their eyes
Make slight jerking movements of their body or limbs
The seizures usually only last up to 15 seconds and you won’t be able to remember them.
They can happen several times a day.

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22
Q

Other types of seizures?

A
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23
Q

Seizure - triggers
What are the triggers for a seizure?

A

Stress
Fatigue
Lights (Photosensitive 3%)
Alcohol
Missing medication
Coffee
Nicotine

24
Q

What are the investigations for a seizure?

A

CT Scan - First Seizure
MRI
EEG – electroencephalogram
Blood tests – to investigate underlying electrolyte cause
low glucose (hypoglycaemia) low sodium (hyponatraemia)

25
What are the treatments for a seizure?
Treatment aims :- minimize or stop seizures completely Treatments include: Anti-epileptic drugs -the main treatment Surgery to remove a small part of the brain that are causing the seizures (Rarely) A procedure to put a small electrical device inside the body that can help control seizures – (Vegus nerve or deep brain stimulation) A special diet (ketogenic diet) that can help control seizures If triggers are known & can be avoided, treatment may be avoided Some people need treatment for life but some might be able to stop treatment if your seizures disappear over time.
26
What are anti epileptic drugs? (AED) Do they cure epilepsy? How often do you use them? Examples?
AEDs are the most commonly used treatment for epilepsy. They help control seizures in about 70% of people. AEDs work by changing the levels of chemicals in your brain. They don't cure epilepsy, but can stop seizures happening. Must be used EVERY day- sudden cessation can provoke a seizure – cessation is slow withdrawal. • Phenytoin • Sodium valproate • Carbamazepine • Lamotrigine • Levetiracetam • Oxcarbazepine • Ethosuximide • Topiramate AED’s have a significant teratogenic profile (cause deformities in foetus in pregnant mum is taking it)
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AEDs - dental relevance?
Trauma Broken restorations Diet Oral Hygiene Compliance Drug Side Effects Phenytoin induced gingival hyperplasia !!!!!
28
Multiple sclerosis What is it ? Affects more males or females? Cause?
Common Neurological Condition (1:1000) Characterised by areas of demyelination in CNS Higher female prevalence Geographic variance in prevalence Unknown cause - ?Viral / Autoimmune mechanism More common in family members, but no known inheritance pattern
29
Multiple sclerosis Pathology? What doesn’t it involve? Predilection for?
Peri-venular plaques of demyelination Predilection for: Optic nerves - (First presentation can be optic neuritis) Periventricular white matter Brainstem & cerebellar connections Cervical spinal cord – corticospinal and dorsal columns MS Does not involve the peripheral nerves. N.B – Guillan Barre Syndrome (Locked in) does affect the peripheral nerves and results in peripheral demyelination)
30
Multiple sclerosis symptoms?
Highly Variable Any symptom starts rapidly before evolving over a few days – peak intensity Symptoms then resolves partially / fully after a few weeks Typically associated with periods of chronic fatigue Axonal blockade -> slowing / ceasing of neuro-conduction “Recovery” Whole / partial regression of perineural oedema & partial re- myelination
31
Multiple sclerosis investigations?
MRI Brain & Spinal cord (CNS) 1st line Ix – demyelination plaques – white lesions – Esp peri-ventricular & Brainstem - Rarely visible on CT Electrophysiology Visual evoked Potentials (light flash - record on optic cortex - ? slowed/ decr amplitude) Auditory evoked Potentials (sound evoked version) Somatosensory – touch smell etc
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Types of multiple sclerosis
33
Multiple Sclerosis - Optic Neuritis
34
Facial pain different types
Allodynia Hyperalgesia Dysaesthesia Hypoalgesia Paraesthesia Anaesthesia Neuralgia Neuropathic Neuropathy
35
Facial pain: Allodynia? Definition
pain from normally non- painful stimulus
36
Facial pain: Hyperalgesia? Definition
increased response to normally painful stimulus
37
Facial pain : Dysaesthesia? Definition
Unpleasant sensation spontaneous or evoked
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Facial pain : Paraesthesia? Definition
abnormal sensation – spontaneous / evoked – not unpleasant
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Facial pain : Hypoalgesia? Definition
diminished pain response to painful stimulus
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Facial pain : Anaesthesia Definition
no pain from painful stimulus
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Facial pain : Neuralgia Definition
nerve distribution pain
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Facial pain : Neuropathic Definition
nerve pathol / damage pain
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Facial pain : Neuropathy Definition
Nerve function / damage / pathology pain
44
Common neurological presentations of facial pain?
Dental pain Trigeminal neuralgia Trigeminal neuropathic pain Trigeminal autonomic cephalgia Post herpetic neuralgia
45
What could dental pain be in new case?
Acute/ chronic pulpitis Dentine sensitivity Perio / Perio-endo
46
What could dental pain be when undergoing treatment ?
High filling Pulp exposure Chemical / thermal irritation (curing lights) Crack cusp? Phoenix abscess Perio-endo Lateral canals??
47
What do we use to take a history of facial pain?
SOCRATES Social history Additional examinations and investigatioms
48
How does Trigeminal neuralgia present?
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What are the causes and treatment of Trigeminal neuralgia?
Causes - majority no cause identified Some - vascular compression of Trigeminal nerve as it leaves skull base Multiple sclerosis Treatment - Carbamazepine Oxcarbaezpine Lamotragine • LA Injections (Temporary) • Nerve ablation (Gamma knife, Thermo, Chemical) • Vascular decompression
50
Glossopharyngeal Neuralgia What is it? What does it affect? What are the triggers?
Paroxysmal pain in ear, base of tongue, tonsillar fossa or angle of jaw Similar treatment modalities as trigeminal neuralgia. Affects sensory areas of IX nerve Triggers chewing, swallowing, talking, yawning and coughing
51
What is post herpetic neuralgia?
Occurs from shingles (herpes zoster) In the elderly and immunosuppressed Pain is steady and sustained Persists for several months Paroxysmal shooting pain Erythema and typical herpetiform rash
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Trigeminal Autonomic Cephalgias
TN like History Localised to V1/2 Recurrent episodic headaches Males – 20-50y/o Peri-orbital pain Fast onset Often autonomic features Red eye Tearing
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Trigeminal Neuropathic Pain
Pain caused by insult to the peripheral nerves. Following removal of the painful stimulus, the pain or altered sensation persists. Some patients report burning sensations. Managed with anti-depressant therapy such as nortriptyline Psychology Self management
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Persistent Idiopathic Facial Pain
Nagging dull throbbing / persecuting pain Doesn’t conform to anatomical boundaries – typically crosses midline Typically doesn’t disturb sleep – awake for diff reason then appreciate the pain Relieved by relaxation / rest Management techniques include pychology – CBT Self management – meditation, stress and lifestyle modulation Antidepressants Nortryptyline, Amitryptiline
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Burning Mouth Syndrome
Idiopathic burning sensation on the tongue. Can also include unusual tastes. Female predisposition Age > 40 Must exclude low Ferritin, B12, Candida Often subjective dry mouth Stress and anxiety can modulate the level of burning Psychology Symptomatic relief (Difflam/lidocaine) Anti-depressants