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3rd Year > Neurological drugs > Flashcards

Neurological drugs Flashcards

1
Q

What drug class is levodopa?

A

Dopamine precursor

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2
Q

What is levodopa used for?

A

Parkinsons disease/parkinsonisms

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3
Q

Why do we have to use a dopamin precursor and not dopamine itself?

A

Dopamine cannot cross the blood brain barrier

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4
Q

Contraindications for levodopa?

A

Closed angle glaucoma

Drug-induced parkinsonism

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5
Q

What is there s risk of if levodopa is combined with Monoamine Oxidase Inhibitors (MAOIs)

A

Hypertensive crisis

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6
Q

What drug class is phenytoin?

A

Anti-convulsant

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7
Q

Which seizure should phenytoin not bu used for?

A

Absence seizures

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8
Q

Indications for phenytoin?

A

Epilepsy (all except absence seizures)

Trigeminal neuralgia

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9
Q

Does phenytoin inhibit or induce hepatic drug metabolising enzymes?

A

Induce

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10
Q

Other than phenytoin name two popular anti-convulsants

A

Carbamezapine

Sodium valproate

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11
Q

Indications for carbamazepine?

A

Generalised tonic-clonic seizures
Partial seizures
Trigeminal neuralgia/chronic neurogenic pain
Bipolar prophylaxis

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12
Q

Corticosteroids, cyclosporin and phenytoin do what to the effect of carbimazapine?

A

Decrease it

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13
Q

What is the first line treatment for all epilepsy?

A

Sodium valproate

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14
Q

Contraindication for sodium valproate?

A 
Hepatic dysfunction (metabolised/excreted by the liver)
Porphyria
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15
Q

What is metoclopramide?

A

Antiemetic (dopamine antagonist)

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16
Q

Indications for antiemetic

A

Nausea
Vomiting
GORD

17
Q

Contraindications for Metoclopramide?

A

Parkinsonism
Intestinal obstruction
1st 3-4 days following GI surgery

18
Q

How does metoclopramide effect NSAIDS?

A

Increases their absorption and so their effects

19
Q

What is lamotrigine used for?

A

Partial seizures
Primary/secondary generalised tonic-clonic seizures
Lennox-gastaut syndrome seizures
Trigeminal neuralgia

3rd Year (18 decks)

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